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We began analyzing https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-025-06109-x, but it redirected us to https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-025-06109-x. The analysis below is for the second page.

Title[redir]:
tRNA-derived small RNAs: their role in the mechanisms, biomarkers, and therapeutic strategies of colorectal cancer | Journal of Translational Medicine | Full Text
Description:
Colorectal cancer (CRC) is the third most prevalent malignancy and the second leading cause of cancer-related mortality worldwide, with an increasing shift towards younger age of onset. In recent years, there has been increasing recognition of the significance of tRNA-derived small RNAs (tsRNAs), encompassing tRNA-derived fragments (tRFs) and tRNA halves (tiRNAs). Their involvement in regulating translation, gene expression, reverse transcription, and epigenetics has gradually come to light. Emerging research has revealed dysregulation of tsRNAs in CRC, implicating their role in CRC initiation and progression, and highlighting their potential in early diagnosis, prognosis, and therapeutic strategies. Although the clinical application of tsRNAs is still in its early stages, recent findings highlight a close relationship between the biogenesis and function of tsRNAs, tRNA chemical modifications, and the tumor immune microenvironment (TIME). Additionally, similar to other small RNAs, tsRNAs can be effectively delivered via nanoparticles (NPs). Consequently, future research should focus on elucidating the clinical significance of tsRNAs concerning base modifications, TIME regulation, cancer immunotherapy, and NPs delivery systems to facilitate their clinical translation.

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Education
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🏙️ Massive Traffic: 50M - 100M visitors per month

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Keywords {🔍}

pubmed, article, google, scholar, cancer, cas, tsrnas, central, crc, trna, zhang, cells, cell, chen, colorectal, wang, trnaderived, rna, httpsdoiorgs, tumor, small, rnas, liu, expression, clinical, modifications, therapeutic, progression, trf, targeting, transcription, potential, yang, modification, immune, fragments, translation, immunotherapy, drug, role, mechanisms, gene, delivery, biological, protein, mol, function, recent, promotes, zhou,

Topics {✒️}

population-level prevalence-based analysis trna-derived small fragment high intratumoral i-trf-gly trna-derived small rnas 5’tirna-gly-gcc positively modulates trmt6/61a-dependent base methylation trna-derived small rna trna-derived rna fragments mettl1-mediated m7g modification 5’tirna-pro-tgg directly targets cafs-derived exosome tsrna-10 myeloid-derived suppressor cells multiple population-based sources functional trna-derived rna including trna-derived fragments hybridization-based labeling techniques exhibits anti-leukemic activity provided constructive feedback encompassing trna-derived fragments 18nt trf-3s compete tirna-val-cac-2 mediates trna-derived fragment biogenesis trf-gln-ctg-026 disrupts downregulated trf-tyr-gta-081 cell-mediated tumor killing ldl receptor-deficient mice eif4a-independent unwinding activity upregulated trf-ala-agc-060 trna-splicing endonuclease components tirna-val-cac-2 interacts respiratory syncytial virus tsrna-5008a silences slc7a11 sperm-borne mitochondrial rnas m7g-related tumor immunity shorter disease-free survival tsrna called trf/mir-1280 block polymers based post-transcriptional chemical modifications cjak1/stat6 signaling pathway small noncoding rnas undergo epithelial-mesenchymal transition pre-trna undergoes processing tsrna-5008a promotes ferroptosis ψ8-tog-5’tsrna generation low-protein diet demonstrated trna-derived fragments privacy choices/manage cookies small interfering rnas small rnas harbored tumor-antagonistic immune cells

Questions {❓}

Why is early detection of colon cancer still not possible in 2023?

Schema {🗺️}

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