We are analyzing https://link.springer.com/article/10.1186/s13045-020-00955-6.

Title:
tRNA-derived RNA fragments in cancer: current status and future perspectives | Journal of Hematology & Oncology
Description:
Non-coding RNAs (ncRNAs) have been the focus of many studies over the last few decades, and their fundamental roles in human diseases have been well established. Transfer RNAs (tRNAs) are housekeeping ncRNAs that deliver amino acids to ribosomes during protein biosynthesis. tRNA fragments (tRFs) are a novel class of small ncRNAs produced through enzymatic cleavage of tRNAs and have been shown to play key regulatory roles similar to microRNAs. Development and application of high-throughput sequencing technologies has provided accumulating evidence of dysregulated tRFs in cancer. Aberrant expression of tRFs has been found to participate in cell proliferation, invasive metastasis, and progression in several human malignancies. These newly identified functional tRFs also have great potential as new biomarkers and therapeutic targets for cancer treatment. In this review, we focus on the major biological functions of tRFs including RNA silencing, translation regulation, and epigenetic regulation; summarize recent research on the roles of tRFs in different types of cancer; and discuss the potential of using tRFs as clinical biomarkers for cancer diagnosis and prognosis and as therapeutic targets for cancer treatment.
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Keywords {🔍}

trfs, pubmed, cancer, google, scholar, cas, cell, rna, trna, central, fragments, trnaderived, trf, rnas, small, expression, human, translation, regulation, breast, cells, sequencing, trnas, biomarkers, types, stress, noncoding, roles, protein, tirnas, study, proliferation, cancers, gene, res, research, metastasis, potential, targets, biol, functional, functions, epigenetic, inhibit, article, development, progression, biological, clinical, role,

Topics {✒️}

wnt/beta-catenin signaling pathway trna-derived stress-induced rnas human photoactivatable-ribonucleoside-enhanced crosslinking hypoxia-induced trna-derived fragments g-quadruplex structures contribute trna-derived fragments gly-trfs taqman qrt-pcr-based method sex hormone-dependent tirna photoactivatable-ribonucleoside-enhanced crosslinking angiogenin-induced trna fragments transfer rna-derived fragments phospho-elf2α-independent assembly high-throughput sequencing technologies trna-derived rna fragments trna-derived small rna correct trna-derived fragments high-throughput sequencing technology germinal center-derived lymphomas trna-derived small rnas post-transcriptionally repress genes hormone-dependent tumors [66] trna-derived fragment competes ribosomal protein s28 transfer rna-related fragments triple-negative breast cancer rna-binding protein overexpressed arsenite-induced cellular responses protein-coding messenger rnas cajal body-specific box long double-stranded rnas heterochromatin-mediated transcriptional repression her2-positive bc decreased hypoxia-induced specific trfs trna-derived fragments biogenesis la/ssb protein rna g-quadruplex article download pdf rna-binding proteins hnrnpf/ initial structure-functional characterization invasive biofluid-based markers functional trf-leu-cag prohibits site-specific cleavage trastuzumab-resistant breast cancer discriminate early-stage bcs urinary bladder carcinoma hypoxia-induced chemoresistance stress-induced 5′-tirnas stress-induced tirnas transfer rna fragments trna-derived fragments

Questions {❓}

TRNA modifications: necessary for correct tRNA-derived fragments during the recovery from stress?

Schema {🗺️}

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         headline:tRNA-derived RNA fragments in cancer: current status and future perspectives
         description:Non-coding RNAs (ncRNAs) have been the focus of many studies over the last few decades, and their fundamental roles in human diseases have been well established. Transfer RNAs (tRNAs) are housekeeping ncRNAs that deliver amino acids to ribosomes during protein biosynthesis. tRNA fragments (tRFs) are a novel class of small ncRNAs produced through enzymatic cleavage of tRNAs and have been shown to play key regulatory roles similar to microRNAs. Development and application of high-throughput sequencing technologies has provided accumulating evidence of dysregulated tRFs in cancer. Aberrant expression of tRFs has been found to participate in cell proliferation, invasive metastasis, and progression in several human malignancies. These newly identified functional tRFs also have great potential as new biomarkers and therapeutic targets for cancer treatment. In this review, we focus on the major biological functions of tRFs including RNA silencing, translation regulation, and epigenetic regulation; summarize recent research on the roles of tRFs in different types of cancer; and discuss the potential of using tRFs as clinical biomarkers for cancer diagnosis and prognosis and as therapeutic targets for cancer treatment.
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            Cancer
            Epigenetic regulation
            RNA silencing
            Translation regulation
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            Cancer Research
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      headline:tRNA-derived RNA fragments in cancer: current status and future perspectives
      description:Non-coding RNAs (ncRNAs) have been the focus of many studies over the last few decades, and their fundamental roles in human diseases have been well established. Transfer RNAs (tRNAs) are housekeeping ncRNAs that deliver amino acids to ribosomes during protein biosynthesis. tRNA fragments (tRFs) are a novel class of small ncRNAs produced through enzymatic cleavage of tRNAs and have been shown to play key regulatory roles similar to microRNAs. Development and application of high-throughput sequencing technologies has provided accumulating evidence of dysregulated tRFs in cancer. Aberrant expression of tRFs has been found to participate in cell proliferation, invasive metastasis, and progression in several human malignancies. These newly identified functional tRFs also have great potential as new biomarkers and therapeutic targets for cancer treatment. In this review, we focus on the major biological functions of tRFs including RNA silencing, translation regulation, and epigenetic regulation; summarize recent research on the roles of tRFs in different types of cancer; and discuss the potential of using tRFs as clinical biomarkers for cancer diagnosis and prognosis and as therapeutic targets for cancer treatment.
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         Biomarkers
         Cancer
         Epigenetic regulation
         RNA silencing
         Translation regulation
         tRNA-derived fragments
         Oncology
         Hematology
         Cancer Research
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      name:Department of Respiratory Medicine, Sir Run Run Shaw Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Zhejiang, China
      name:Department of Head and Neck Surgery, Cancer Hospital of the University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Key Laboratory of Head & Neck Cancer Translational Research of Zhejiang Province, Hangzhou, China
      name:Department of Respiratory Medicine, Sir Run Run Shaw Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Zhejiang, China
      name:Center of Systems Molecular Medicine, Department of Physiology, Medical College of Wisconsin, Milwaukee, USA
      name:Center for Uterine Cancer Diagnosis & Therapy Research of Zhejiang Province, Women’s Reproductive Health Key Laboratory of Zhejiang Province, Department of Gynecologic Oncology, Women’s Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China

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