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tissues, crc, trfb, trfs, additional, fig, file, exosomes, trfgroup, table, plasma, analysis, article, mif, study, cancer, cells, macrophage, high, genes, expression, lgals, gene, low, trnaderived, cell, colorectal, patients, tumor, differentially, expressed, nanjing, polarization, sequencing, rna, data, information, tao, small, normal, controls, results, enrichment, levels, google, scholar, chinese, medicine, fragments, adjacent,

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trna-derived small rnas trna-derived fragments cytokine-cytokine receptor interaction volcano plot showing trf-regulated factors english language editing lna_3022b-transfected hct116 cells article download pdf natural science research induces cell apoptosis m2 macrophage polarization privacy choices/manage cookies cell-derived exosomes promoted cellular apoptosis haibo cheng m2 macrophage marker induces m2 polarization adjacent normal tissues full size image trf-3022b probe amino acid carriers transmission electron micrograph dongdong sun locked nucleic acids differentially expressed genes receptor signaling pathway creative commons licence silencing trf-3022b trf-3022b binds detect trf-3022b m2 macrophage markers subcutaneous xenograft tumors talents cultivation program colorectal cancer il-17 signaling pathway cell death dis trf-3022b-knockdown trf-3022b knockdown small rna sequencing central dogma independently cluster heat map dna damage response institutional animal care gene expression profile target genes regulated enrichment assays showed supplementary information files conditions privacy policy western blot analysis trigger mrna degradation

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         headline:A novel tRNA-derived fragment tRF-3022b modulates cell apoptosis and M2 macrophage polarization via binding to cytokines in colorectal cancer
         description:tRNA-derived fragments (tRFs) are a class of small RNAs that occur when tRNAs are broken down by enzymes due to stress. Increasing reports have shown that tRFs are associated with multiple physiological and pathological processes, especially in cancers; however, very little is known of the effects and mechanisms of tRFs. Therefore, further investigation on the biological roles and clinical value of tRFs is required. In this study, we utilized whole-transcriptome sequencing to profile tRFs expression in the tissues and plasma exosomes of patients with colorectal cancer (CRC). Three tRFs (tRF-3022b, tRF-3030b and tRF-5008b) showed an increasing trend in CRC tissues compared to adjacent normal tissues. They also tended to be elevated in plasma exosomes of CRC patients compared to healthy controls. These results indicated that they may be upregulated in cancer cells and then secreted by exosomes. The knockdown of tRF-regulated factors such as AlkB homolog 3 (ALKBH3), tRNA aspartic acid methyltransferase 1 (DNMT2), angiogenin (ANG), and argonaute RISC catalytic component 2 (AGO2) could affect the expression of tRFs. Notably, we found that the decrease in the three tRFs arrests the progression of the CRC cell cycle and induces cell apoptosis. Silencing tRF-3022b could facilitate M2 macrophage polarization. Mechanistically, we found that tRF-3022b binds to galectin 1 (LGALS1) and macrophage migration inhibitory factor (MIF) in CRC cells and reduces polarization by regulating MIF in M2 macrophages. In conclusion, our study revealed the expression pattern of tRFs in both tissue and plasma exosomes and identified a novel tRF, tRF-3022b, which may affect CRC tumor growth and M2 macrophage polarization by binding to LGALS1 and MIF.
         datePublished:2022-12-16T00:00:00Z
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      headline:A novel tRNA-derived fragment tRF-3022b modulates cell apoptosis and M2 macrophage polarization via binding to cytokines in colorectal cancer
      description:tRNA-derived fragments (tRFs) are a class of small RNAs that occur when tRNAs are broken down by enzymes due to stress. Increasing reports have shown that tRFs are associated with multiple physiological and pathological processes, especially in cancers; however, very little is known of the effects and mechanisms of tRFs. Therefore, further investigation on the biological roles and clinical value of tRFs is required. In this study, we utilized whole-transcriptome sequencing to profile tRFs expression in the tissues and plasma exosomes of patients with colorectal cancer (CRC). Three tRFs (tRF-3022b, tRF-3030b and tRF-5008b) showed an increasing trend in CRC tissues compared to adjacent normal tissues. They also tended to be elevated in plasma exosomes of CRC patients compared to healthy controls. These results indicated that they may be upregulated in cancer cells and then secreted by exosomes. The knockdown of tRF-regulated factors such as AlkB homolog 3 (ALKBH3), tRNA aspartic acid methyltransferase 1 (DNMT2), angiogenin (ANG), and argonaute RISC catalytic component 2 (AGO2) could affect the expression of tRFs. Notably, we found that the decrease in the three tRFs arrests the progression of the CRC cell cycle and induces cell apoptosis. Silencing tRF-3022b could facilitate M2 macrophage polarization. Mechanistically, we found that tRF-3022b binds to galectin 1 (LGALS1) and macrophage migration inhibitory factor (MIF) in CRC cells and reduces polarization by regulating MIF in M2 macrophages. In conclusion, our study revealed the expression pattern of tRFs in both tissue and plasma exosomes and identified a novel tRF, tRF-3022b, which may affect CRC tumor growth and M2 macrophage polarization by binding to LGALS1 and MIF.
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         tRNA-derived fragments
         tRF-3022b
         LGALS1
         MIF
         Colorectal cancer
         Oncology
         Hematology
         Cancer Research
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      name:Dan Dong
      affiliation:
            name:Nanjing University of Chinese Medicine
            address:
               name:The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, China
               type:PostalAddress
            type:Organization
            name:Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor
            address:
               name:Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing, China
               type:PostalAddress
            type:Organization
      name:Wenlong Hu
      affiliation:
            name:Nanjing University of Chinese Medicine
            address:
               name:The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, China
               type:PostalAddress
            type:Organization
            name:Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor
            address:
               name:Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing, China
               type:PostalAddress
            type:Organization
      name:Qinchang Zhang
      affiliation:
            name:Nanjing University of Chinese Medicine
            address:
               name:The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, China
               type:PostalAddress
            type:Organization
            name:Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor
            address:
               name:Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing, China
               type:PostalAddress
            type:Organization
      name:Yuquan Tao
      affiliation:
            name:Nanjing University of Chinese Medicine
            address:
               name:The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, China
               type:PostalAddress
            type:Organization
            name:Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor
            address:
               name:Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing, China
               type:PostalAddress
            type:Organization
      name:Chengtao Yu
      affiliation:
            name:Nanjing University of Chinese Medicine
            address:
               name:The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, China
               type:PostalAddress
            type:Organization
            name:Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor
            address:
               name:Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Dongdong Sun
      affiliation:
            name:Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor
            address:
               name:Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing, China
               type:PostalAddress
            type:Organization
            name:Nanjing University of Chinese Medicine
            address:
               name:School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Haibo Cheng
      affiliation:
            name:Nanjing University of Chinese Medicine
            address:
               name:The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, China
               type:PostalAddress
            type:Organization
            name:Affiliated Hospital of Nanjing University of Chinese Medicine
            address:
               name:Department of Oncology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China
               type:PostalAddress
            type:Organization
            name:Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor
            address:
               name:Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, China
      name:Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing, China
      name:The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, China
      name:Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing, China
      name:The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, China
      name:Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing, China
      name:The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, China
      name:Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing, China
      name:The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, China
      name:Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing, China
      name:The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, China
      name:Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing, China
      name:The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, China
      name:Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing, China
      name:The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, China
      name:Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing, China
      name:Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing, China
      name:School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China
      name:The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, China
      name:Department of Oncology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China
      name:Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing, China

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