DOI . ORG {}

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We began analyzing https://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr2889, but it redirected us to https://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr2889. The analysis below is for the second page.

Title[redir]:
Choosing the right cell line for breast cancer research | Breast Cancer Research | Full Text
Description:
Breast cancer is a complex and heterogeneous disease. Gene expression profiling has contributed significantly to our understanding of this heterogeneity at a molecular level, refining taxonomy based on simple measures such as histological type, tumour grade, lymph node status and the presence of predictive markers like oestrogen receptor and human epidermal growth factor receptor 2 (HER2) to a more sophisticated classification comprising luminal A, luminal B, basal-like, HER2-positive and normal subgroups. In the laboratory, breast cancer is often modelled using established cell lines. In the present review we discuss some of the issues surrounding the use of breast cancer cell lines as experimental models, in light of these revised clinical classifications, and put forward suggestions for improving their use in translational breast cancer research.

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Education
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🚄 Respectable Traffic: 10k - 20k visitors per month

Based on our best estimate, this website will receive around 10,019 visitors per month in the current month.
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Keywords {🔍}

cancer, breast, cell, pubmed, google, scholar, article, lines, cells, cas, human, line, models, mdamb, central, res, expression, culture, molecular, mammary, growth, luminal, basal, epithelial, threedimensional, research, gene, tumour, metastatic, phenotype, carcinoma, tumours, vitro, normal, derived, biol, profiling, cscs, studies, model, response, tissue, stem, structures, metastasis, authors, heterogeneity, receptor, mcf, study,

Topics {✒️}

springer nature cell-cell adhesion molecules male breast cancer systemic cell-cycle suppression n-terminal recombinant fragment author information authors triple-negative breast cancer branching ductal-alveolar morphogenesis tgf-β mediated mechanism phenotype cd44+cd24-/lowlin high-resolution integrated analysis hybrid mouse-human nuclei triple-negative breast cancers her2- positive mda-mb-453 claudin-low mda-mb-231 cd44+cd24-/low phenotype cd44+/cd24-/low phenotype [30] epidermal growth factor authors’ original file authors scientific editing mda-mb-435 melanoma cells fulvestrant versus anastrozole claudin-low clusters identified claudin-low intrinsic subtype human cell line human breast cancer privacy choices/manage cookies basal cell line cell line models breast cancer cells holliday & valerie speirs cell line authentication cell line' studies cell line panels human breast cells anti-oestrogens regulated accompany manuscript submission cell line derived breast epithelial growth basal breast cancer human breast carcinomas bmc breast cancer research breast carcinoma cells article holliday cell lines grown single cell line melanoma cell line breast cancer therapies inflammatory breast cancer

Questions {❓}

Burdall SE, Hanby AM, Lansdown MRJ, Speirs V: Breast cancer cell lines: friend or foe?
Do current breast cancer cell line models reflect breast cancer heterogeneity?

Schema {🗺️}

WebPage:
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