We are analyzing https://link.springer.com/article/10.1007/s10549-009-0460-8.

Title:
Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines | Breast Cancer Research and Treatment
Description:
Breast cancer has for long been recognized as a highly diverse tumor group, but the underlying genetic basis has been elusive. Here, we report an extensive molecular characterization of a collection of 41 human breast cancer cell lines. Protein and gene expression analyses indicated that the collection of breast cancer cell lines has retained most, if not all, molecular characteristics that are typical for clinical breast cancers. Gene mutation analyses identified 146 oncogenic mutations among 27 well-known cancer genes, amounting to an average of 3.6 mutations per cell line. Mutations in genes from the p53, RB and PI3K tumor suppressor pathways were widespread among all breast cancer cell lines. Most important, we have identified two gene mutation profiles that are specifically associated with luminal-type and basal-type breast cancer cell lines. The luminal mutation profile involved E-cadherin and MAP2K4 gene mutations and amplifications of Cyclin D1, ERBB2 and HDM2, whereas the basal mutation profile involved BRCA1, RB1, RAS and BRAF gene mutations and deletions of p16 and p14ARF. These subtype-specific gene mutation profiles constitute a genetic basis for the heterogeneity observed among human breast cancers, providing clues for their underlying biology and providing guidance for targeted pharmacogenetic intervention in breast cancer patients.
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cancer, breast, article, google, scholar, pubmed, cas, cell, res, human, gene, lines, mutation, van, mutations, carcinoma, schutte, netherlands, research, hollestelle, klijn, molecular, foekens, expression, basal, access, erasmus, medical, center, profiles, nagel, wasielewski, ethier, tumor, cancers, subtypes, treat, department, university, rotterdam, privacy, cookies, content, analysis, smid, elstrodt, brca, biology, usa, wang,

Topics {✒️}

ser sue ng month download article/chapter node-negative breast cancer genome-wide expression patterns familial breast cancer breast tumor subtypes gene mutation profiles molecular cell biology brca1 mutation analysis primary breast carcinoma related subjects somatic mutation profiles human breast cancers van der spek human breast carcinoma human e-cadherin borresen-dale al gene expression analyses m14 cell lines clinical breast cancers human breast cancer stem cell research invasive breast carcinoma gene-expression profiles full article pdf section surgical oncology mda-mb-435 cells international cancer research recurrent breast cancer inherited breast cancer gruvberger-saal sk privacy choices/manage cookies human breast tumours hans clevers el-sayed van der kooy van der heyden basal cytokeratin expression breast cancer patients van de rijn josephine nefkens institute netherlands genomics initiative chemically defined medium effect oncogenic transformation molecular understanding potential molecular markers braf gene mutations dutch cancer society candidate tumor suppressor author information authors

Questions {❓}

Chambers AF (2009) MDA-MB-435 and M14 Cell Lines: identical but not M14 Melanoma?

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         headline:Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines
         description:Breast cancer has for long been recognized as a highly diverse tumor group, but the underlying genetic basis has been elusive. Here, we report an extensive molecular characterization of a collection of 41 human breast cancer cell lines. Protein and gene expression analyses indicated that the collection of breast cancer cell lines has retained most, if not all, molecular characteristics that are typical for clinical breast cancers. Gene mutation analyses identified 146 oncogenic mutations among 27 well-known cancer genes, amounting to an average of 3.6 mutations per cell line. Mutations in genes from the p53, RB and PI3K tumor suppressor pathways were widespread among all breast cancer cell lines. Most important, we have identified two gene mutation profiles that are specifically associated with luminal-type and basal-type breast cancer cell lines. The luminal mutation profile involved E-cadherin and MAP2K4 gene mutations and amplifications of Cyclin D1, ERBB2 and HDM2, whereas the basal mutation profile involved BRCA1, RB1, RAS and BRAF gene mutations and deletions of p16 and p14ARF. These subtype-specific gene mutation profiles constitute a genetic basis for the heterogeneity observed among human breast cancers, providing clues for their underlying biology and providing guidance for targeted pharmacogenetic intervention in breast cancer patients.
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            Histological classification
            Intrinsic subtypes
            Molecular classification
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