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Keywords {🔍}

cancer, breast, pubmed, article, google, scholar, research, cas, patients, clinical, risk, cells, studies, disease, therapies, analysis, progression, tumour, brca, development, treatment, mammary, women, cell, growth, markers, gap, response, pathways, psychosocial, gene, prevention, models, gaps, signalling, understanding, receptor, study, data, central, trials, therapy, methods, stem, early, table, expression, screening, gland, tissue,

Topics {✒️}

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Questions {❓}

• Bingham SA, Luben R, Welch A, Wareham N, Khaw KT, Day N: Are imprecise methods obscuring a relation between fat and breast cancer?
• Exploiting the potential of gene expression profiling: is it ready for the clinic?
• For example, does attending screening negate women's interest in prevention strategies because many women perceive screening as prevention?
• How do anti-cancer treatments adversely affect cancer cells?
• How to decide when to stop treatment?
• Kamb A: What's wrong with our cancer models?
• Maurice A, Evans DG, Shenton A, Ashcroft L, Baildam A, Barr L, Byrne G, Bundred N, Boggis C, Wilson M, Duffy SW, Howell A: Screening younger women with a family history of breast cancer – does early detection improve outcome?
• The key question is: does introducing a new marker change clinical practice and therefore patient outcome?
• What are the gaps?
• What are the problems?
• What do we know?
• Who will develop drug-resistant tumours?

Schema {🗺️}

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         headline:Evaluation of the current knowledge limitations in breast cancer research: a gap analysis
         description:A gap analysis was conducted to determine which areas of breast cancer research, if targeted by researchers and funding bodies, could produce the greatest impact on patients. Fifty-six Breast Cancer Campaign grant holders and prominent UK breast cancer researchers participated in a gap analysis of current breast cancer research. Before, during and following the meeting, groups in seven key research areas participated in cycles of presentation, literature review and discussion. Summary papers were prepared by each group and collated into this position paper highlighting the research gaps, with recommendations for action. Gaps were identified in all seven themes. General barriers to progress were lack of financial and practical resources, and poor collaboration between disciplines. Critical gaps in each theme included: (1) genetics (knowledge of genetic changes, their effects and interactions); (2) initiation of breast cancer (how developmental signalling pathways cause ductal elongation and branching at the cellular level and influence stem cell dynamics, and how their disruption initiates tumour formation); (3) progression of breast cancer (deciphering the intracellular and extracellular regulators of early progression, tumour growth, angiogenesis and metastasis); (4) therapies and targets (understanding who develops advanced disease); (5) disease markers (incorporating intelligent trial design into all studies to ensure new treatments are tested in patient groups stratified using biomarkers); (6) prevention (strategies to prevent oestrogen-receptor negative tumours and the long-term effects of chemoprevention for oestrogen-receptor positive tumours); (7) psychosocial aspects of cancer (the use of appropriate psychosocial interventions, and the personal impact of all stages of the disease among patients from a range of ethnic and demographic backgrounds). Through recommendations to address these gaps with future research, the long-term benefits to patients will include: better estimation of risk in families with breast cancer and strategies to reduce risk; better prediction of drug response and patient prognosis; improved tailoring of treatments to patient subgroups and development of new therapeutic approaches; earlier initiation of treatment; more effective use of resources for screening populations; and an enhanced experience for people with or at risk of breast cancer and their families. The challenge to funding bodies and researchers in all disciplines is to focus on these gaps and to drive advances in knowledge into improvements in patient care.
         datePublished:2008-03-27T00:00:00Z
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            Breast Cancer
            Sentinel Lymph Node
            Mammographic Density
            Breast Screening
            Breast Cancer Research
            Cancer Research
            Oncology
            Surgical Oncology
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      headline:Evaluation of the current knowledge limitations in breast cancer research: a gap analysis
      description:A gap analysis was conducted to determine which areas of breast cancer research, if targeted by researchers and funding bodies, could produce the greatest impact on patients. Fifty-six Breast Cancer Campaign grant holders and prominent UK breast cancer researchers participated in a gap analysis of current breast cancer research. Before, during and following the meeting, groups in seven key research areas participated in cycles of presentation, literature review and discussion. Summary papers were prepared by each group and collated into this position paper highlighting the research gaps, with recommendations for action. Gaps were identified in all seven themes. General barriers to progress were lack of financial and practical resources, and poor collaboration between disciplines. Critical gaps in each theme included: (1) genetics (knowledge of genetic changes, their effects and interactions); (2) initiation of breast cancer (how developmental signalling pathways cause ductal elongation and branching at the cellular level and influence stem cell dynamics, and how their disruption initiates tumour formation); (3) progression of breast cancer (deciphering the intracellular and extracellular regulators of early progression, tumour growth, angiogenesis and metastasis); (4) therapies and targets (understanding who develops advanced disease); (5) disease markers (incorporating intelligent trial design into all studies to ensure new treatments are tested in patient groups stratified using biomarkers); (6) prevention (strategies to prevent oestrogen-receptor negative tumours and the long-term effects of chemoprevention for oestrogen-receptor positive tumours); (7) psychosocial aspects of cancer (the use of appropriate psychosocial interventions, and the personal impact of all stages of the disease among patients from a range of ethnic and demographic backgrounds). Through recommendations to address these gaps with future research, the long-term benefits to patients will include: better estimation of risk in families with breast cancer and strategies to reduce risk; better prediction of drug response and patient prognosis; improved tailoring of treatments to patient subgroups and development of new therapeutic approaches; earlier initiation of treatment; more effective use of resources for screening populations; and an enhanced experience for people with or at risk of breast cancer and their families. The challenge to funding bodies and researchers in all disciplines is to focus on these gaps and to drive advances in knowledge into improvements in patient care.
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      dateModified:2008-03-27T00:00:00Z
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      keywords:
         Breast Cancer
         Sentinel Lymph Node
         Mammographic Density
         Breast Screening
         Breast Cancer Research
         Cancer Research
         Oncology
         Surgical Oncology
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      name:Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, Cardiff, UK
      name:The Centre for Appearance Research, School of Psychology University of the West of England, Bristol, UK
      name:Cancer Research UK Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Headington, UK
      name:Family History Clinic, Nightingale & Genesis Prevention Centre, Wythenshawe Hospital, Manchester, UK
      name:Academic Unit of Clinical Oncology, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, UK
      name:Breast Cancer Prevention Centre, South Manchester University Hospitals NHS Trust, Manchester, UK
      name:Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, Cardiff, UK
      name:University of St Andrews, Bute Medical School, University of St Andrews, Fife, UK
      name:Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, UK

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