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  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
  8. Questions
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We are analyzing https://link.springer.com/article/10.1007/s10549-008-0296-7.

Title:
A high-resolution integrated analysis of genetic and expression profiles of breast cancer cell lines | Breast Cancer Research and Treatment
Description:
Tumour cell lines derived from breast cancer patients constitute one of the cornerstones of breast cancer research. To characterise breast cancer cell lines at the genetic level, we have developed a full tiling path bacterial artificial chromosome (BAC) array collection for comparative genomic hybridisation (aCGH). This aCGH BAC collection covers 98% of the entire human genome at a resolution of 40–60 kbp. We have used this platform alongside an in-house produced 17 K cDNA microarray set to characterise the genetic and transcriptomic profiles of 24 breast cancer cell lines, as well as cell types derived from non-diseased breast. We demonstrate that breast cancer cell lines have genomic and transcriptomic features that recapitulate those of primary breast cancers and can be reliably subclassified into basal-like and luminal subgroups. By overlaying aCGH and transcriptomic data, we have identified 753 genes whose expression correlate with copy number; this list comprised numerous oncogenes recurrently amplified and overexpressed in breast cancer (e.g., HER2, MYC, CCND1 and AURKA). Finally, we demonstrate that although breast cancer cell lines have genomic features usually found in grade III breast cancers (i.e., gains of 1q, 8q and 20q), basal-like and luminal cell lines are characterised by distinct genomic aberrations.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Education
  • Health & Fitness
  • Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
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How Does Link.springer.com Make Money? {💸}

We don’t know how the website earns money.

Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Link.springer.com could be secretly minting cash, but we can't detect the process.

Keywords {🔍}

cancer, breast, article, google, scholar, pubmed, cas, cell, genomic, res, lines, expression, gene, analysis, research, profiling, author, reisfilho, human, cancers, molecular, amplification, carcinomas, nat, access, clin, genet, profiles, comparative, basallike, privacy, cookies, content, data, mackay, grigoriadis, array, acgh, luminal, genes, cells, lambros, pathol, doipath, esr, common, reply, identification, doican, publish,

Topics {✒️}

reis-filho & alan ashworth month download article/chapter reis-filho js high-resolution genomic profiles 20q13-amplified breast cancers high-resolution integrated analysis full article pdf her2-amplified breast cancers luminal cell lines high-resolution acgh cell types derived anita grigoriadis breast cancer research invasive breast cancer privacy choices/manage cookies human mammary luminal breakthrough breast cancer comparative genomic hybridisation related subjects cancer research uk bmc genomics 7 expression profiling identifies array cgh profiles entire human genome gene-expression subtypes human breast tumours primary breast cancers breast tumor subtypes luminal breast cancers advanced breast cancer breast cancer pathophysiologies primary breast cancer her2/top2a amplicon article mackay false discovery rate gene expression profiling cdna microarray set epigenetically silenced gene metaplastic breast carcinomas lobular breast carcinomas situ hybridization analysis human glioma cells european economic area check access extremely low tumorigenicity transcriptional aberrations linked immunomagnetic separation method large-scale purification pleomorphic lobular carcinoma stat soc [ser

Questions {❓}

  • Brenton JD, Carey LA, Ahmed AA et al (2005) Molecular classification and molecular forecasting of breast cancer: ready for clinical application?
  • Brown LA, Hoog J, Chin SF et al (2008) ESR1 gene amplification in breast cancer: a common phenomenon?
  • Horlings HM, Bergamaschi A, Nordgard SH et al (2008) ESR1 gene amplification in breast cancer: a common phenomenon?
  • Reis-Filho JS, Drury S, Lambros MB et al (2008) ESR1 gene amplification in breast cancer: a common phenomenon?
  • Vincent-Salomon A, Raynal V, Lucchesi C et al (2008) ESR1 gene amplification in breast cancer: a common phenomenon?

Schema {🗺️}

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         headline:A high-resolution integrated analysis of genetic and expression profiles of breast cancer cell lines
         description:Tumour cell lines derived from breast cancer patients constitute one of the cornerstones of breast cancer research. To characterise breast cancer cell lines at the genetic level, we have developed a full tiling path bacterial artificial chromosome (BAC) array collection for comparative genomic hybridisation (aCGH). This aCGH BAC collection covers 98% of the entire human genome at a resolution of 40–60 kbp. We have used this platform alongside an in-house produced 17 K cDNA microarray set to characterise the genetic and transcriptomic profiles of 24 breast cancer cell lines, as well as cell types derived from non-diseased breast. We demonstrate that breast cancer cell lines have genomic and transcriptomic features that recapitulate those of primary breast cancers and can be reliably subclassified into basal-like and luminal subgroups. By overlaying aCGH and transcriptomic data, we have identified 753 genes whose expression correlate with copy number; this list comprised numerous oncogenes recurrently amplified and overexpressed in breast cancer (e.g., HER2, MYC, CCND1 and AURKA). Finally, we demonstrate that although breast cancer cell lines have genomic features usually found in grade III breast cancers (i.e., gains of 1q, 8q and 20q), basal-like and luminal cell lines are characterised by distinct genomic aberrations.
         datePublished:2009-01-24T00:00:00Z
         dateModified:2009-01-24T00:00:00Z
         pageStart:481
         pageEnd:498
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            Oncology
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      headline:A high-resolution integrated analysis of genetic and expression profiles of breast cancer cell lines
      description:Tumour cell lines derived from breast cancer patients constitute one of the cornerstones of breast cancer research. To characterise breast cancer cell lines at the genetic level, we have developed a full tiling path bacterial artificial chromosome (BAC) array collection for comparative genomic hybridisation (aCGH). This aCGH BAC collection covers 98% of the entire human genome at a resolution of 40–60 kbp. We have used this platform alongside an in-house produced 17 K cDNA microarray set to characterise the genetic and transcriptomic profiles of 24 breast cancer cell lines, as well as cell types derived from non-diseased breast. We demonstrate that breast cancer cell lines have genomic and transcriptomic features that recapitulate those of primary breast cancers and can be reliably subclassified into basal-like and luminal subgroups. By overlaying aCGH and transcriptomic data, we have identified 753 genes whose expression correlate with copy number; this list comprised numerous oncogenes recurrently amplified and overexpressed in breast cancer (e.g., HER2, MYC, CCND1 and AURKA). Finally, we demonstrate that although breast cancer cell lines have genomic features usually found in grade III breast cancers (i.e., gains of 1q, 8q and 20q), basal-like and luminal cell lines are characterised by distinct genomic aberrations.
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      dateModified:2009-01-24T00:00:00Z
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         Cell lines
         aCGH
         Oncology
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                  address:
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                  address:
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                  address:
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                     type:PostalAddress
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                  name:Guy’s Hospital
                  address:
                     name:The Breakthrough Breast Cancer Research Unit, King’s College London School of Medicine, Guy’s Hospital, London, UK
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            type:Person
            name:Tim Dexter
            affiliation:
                  name:The Institute of Cancer Research
                  address:
                     name:The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
                     type:PostalAddress
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            name:Christopher J. Lord
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                  name:The Institute of Cancer Research
                  address:
                     name:The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
                     type:PostalAddress
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                  address:
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                     type:PostalAddress
                  type:Organization
            type:Person
            name:Alan Ashworth
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         name:The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
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         name:The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
         type:PostalAddress
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      address:
         name:The Breakthrough Breast Cancer Research Unit, King’s College London School of Medicine, Guy’s Hospital, London, UK
         type:PostalAddress
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      address:
         name:The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
         type:PostalAddress
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         name:The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
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         name:The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
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      name:Narinder Tamber
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            name:The Institute of Cancer Research
            address:
               name:The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
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            name:The Institute of Cancer Research
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               name:The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
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            name:The Institute of Cancer Research
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               name:The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
               type:PostalAddress
            type:Organization
      name:Anita Grigoriadis
      affiliation:
            name:The Institute of Cancer Research
            address:
               name:The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
               type:PostalAddress
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            address:
               name:The Breakthrough Breast Cancer Research Unit, King’s College London School of Medicine, Guy’s Hospital, London, UK
               type:PostalAddress
            type:Organization
      name:Tim Dexter
      affiliation:
            name:The Institute of Cancer Research
            address:
               name:The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
               type:PostalAddress
            type:Organization
      name:Christopher J. Lord
      affiliation:
            name:The Institute of Cancer Research
            address:
               name:The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
               type:PostalAddress
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      email:[email protected]
      name:Jorge S. Reis-Filho
      affiliation:
            name:The Institute of Cancer Research
            address:
               name:The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
               type:PostalAddress
            type:Organization
      name:Alan Ashworth
      affiliation:
            name:The Institute of Cancer Research
            address:
               name:The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
               type:PostalAddress
            type:Organization
PostalAddress:
      name:The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
      name:The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
      name:The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
      name:The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
      name:The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
      name:The Breakthrough Breast Cancer Research Unit, King’s College London School of Medicine, Guy’s Hospital, London, UK
      name:The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
      name:The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
      name:The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
      name:The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
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External Links {🔗}(250)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Clipboard.js
  • Prism.js

CDN Services {📦}

  • Crossref

4.3s.