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Title:
Guidelines and definitions for research on epithelial–mesenchymal transition | Nature Reviews Molecular Cell Biology
Description:
Epithelial–mesenchymal transition (EMT) encompasses dynamic changes in cellular organization from epithelial to mesenchymal phenotypes, which leads to functional changes in cell migration and invasion. EMT occurs in a diverse range of physiological and pathological conditions and is driven by a conserved set of inducing signals, transcriptional regulators and downstream effectors. With over 5,700 publications indexed by Web of Science in 2019 alone, research on EMT is expanding rapidly. This growing interest warrants the need for a consensus among researchers when referring to and undertaking research on EMT. This Consensus Statement, mediated by ‘the EMT International Association’ (TEMTIA), is the outcome of a 2-year-long discussion among EMT researchers and aims to both clarify the nomenclature and provide definitions and guidelines for EMT research in future publications. We trust that these guidelines will help to reduce misunderstanding and misinterpretation of research data generated in various experimental models and to promote cross-disciplinary collaboration to identify and address key open questions in this research field. While recognizing the importance of maintaining diversity in experimental approaches and conceptual frameworks, we emphasize that lasting contributions of EMT research to increasing our understanding of developmental processes and combatting cancer and other diseases depend on the adoption of a unified terminology to describe EMT. In this Consensus Statement, the authors (on behalf of the EMT International Association) propose guidelines to define epithelial–mesenchymal transition, its phenotypic plasticity and the associated multiple intermediate epithelial–mesenchymal cell states. Clarification of nomenclature and definitions will help reduce misinterpretation of research data generated in different experimental model systems and promote cross-disciplinary collaboration.
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- Carcinoma invasion and metastasis: a role for epithelial–mesenchymal transition?
- Epithelial–mesenchymal transition (EMT) and metastasis: yes, no, maybe?
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- The relevance of EMT in breast cancer metastasis: correlation or causality?
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headline:Guidelines and definitions for research on epithelialâmesenchymal transition
description:Epithelialâmesenchymal transition (EMT) encompasses dynamic changes in cellular organization from epithelial to mesenchymal phenotypes, which leads to functional changes in cell migration and invasion. EMT occurs in a diverse range of physiological and pathological conditions and is driven by a conserved set of inducing signals, transcriptional regulators and downstream effectors. With over 5,700 publications indexed by Web of Science in 2019 alone, research on EMT is expanding rapidly. This growing interest warrants the need for a consensus among researchers when referring to and undertaking research on EMT. This Consensus Statement, mediated by âthe EMT International Associationâ (TEMTIA), is the outcome of a 2-year-long discussion among EMT researchers and aims to both clarify the nomenclature and provide definitions and guidelines for EMT research in future publications. We trust that these guidelines will help to reduce misunderstanding and misinterpretation of research data generated in various experimental models and to promote cross-disciplinary collaboration to identify and address key open questions in this research field. While recognizing the importance of maintaining diversity in experimental approaches and conceptual frameworks, we emphasize that lasting contributions of EMT research to increasing our understanding of developmental processes and combatting cancer and other diseases depend on the adoption of a unified terminology to describe EMT. In this Consensus Statement, the authors (on behalf of the EMT International Association) propose guidelines to define epithelialâmesenchymal transition, its phenotypic plasticity and the associated multiple intermediate epithelialâmesenchymal cell states. Clarification of nomenclature and definitions will help reduce misinterpretation of research data generated in different experimental model systems and promote cross-disciplinary collaboration.
datePublished:2020-04-16T00:00:00Z
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Developmental biology
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headline:Guidelines and definitions for research on epithelialâmesenchymal transition
description:Epithelialâmesenchymal transition (EMT) encompasses dynamic changes in cellular organization from epithelial to mesenchymal phenotypes, which leads to functional changes in cell migration and invasion. EMT occurs in a diverse range of physiological and pathological conditions and is driven by a conserved set of inducing signals, transcriptional regulators and downstream effectors. With over 5,700 publications indexed by Web of Science in 2019 alone, research on EMT is expanding rapidly. This growing interest warrants the need for a consensus among researchers when referring to and undertaking research on EMT. This Consensus Statement, mediated by âthe EMT International Associationâ (TEMTIA), is the outcome of a 2-year-long discussion among EMT researchers and aims to both clarify the nomenclature and provide definitions and guidelines for EMT research in future publications. We trust that these guidelines will help to reduce misunderstanding and misinterpretation of research data generated in various experimental models and to promote cross-disciplinary collaboration to identify and address key open questions in this research field. While recognizing the importance of maintaining diversity in experimental approaches and conceptual frameworks, we emphasize that lasting contributions of EMT research to increasing our understanding of developmental processes and combatting cancer and other diseases depend on the adoption of a unified terminology to describe EMT. In this Consensus Statement, the authors (on behalf of the EMT International Association) propose guidelines to define epithelialâmesenchymal transition, its phenotypic plasticity and the associated multiple intermediate epithelialâmesenchymal cell states. Clarification of nomenclature and definitions will help reduce misinterpretation of research data generated in different experimental model systems and promote cross-disciplinary collaboration.
datePublished:2020-04-16T00:00:00Z
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keywords:
Cancer
Developmental biology
Epithelialâmesenchymal transition
Life Sciences
general
Cell Biology
Cancer Research
Developmental Biology
Stem Cells
Biochemistry
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type:Organization
name:Joan Massagué
affiliation:
name:Memorial Sloan Kettering Cancer Center
address:
name:Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, USA
type:PostalAddress
type:Organization
name:Roberto Mayor
url:http://orcid.org/0000-0001-9053-9613
affiliation:
name:University College London
address:
name:Department of Cell and Developmental Biology, University College London, London, UK
type:PostalAddress
type:Organization
name:David McClay
affiliation:
name:Duke University
address:
name:Department of Biology, Duke University, Durham, USA
type:PostalAddress
type:Organization
name:Keith E. Mostov
url:http://orcid.org/0000-0002-8123-6247
affiliation:
name:University of California, San Francisco, School of Medicine
address:
name:Departments of Anatomy and Biochemistry/Biophysics, University of California, San Francisco, School of Medicine, San Francisco, USA
type:PostalAddress
type:Organization
name:Donald F. Newgreen
url:http://orcid.org/0000-0002-3467-6389
affiliation:
name:Murdoch Childrenâs Research Institute, Royal Childrenâs Hospital
address:
name:Murdoch Childrenâs Research Institute, Royal Childrenâs Hospital, Parkville, Australia
type:PostalAddress
type:Organization
name:M. Angela Nieto
url:http://orcid.org/0000-0002-3538-840X
affiliation:
name:Instituto de Neurociencias (CSIC-UMH) Avda Ramon y Cajal s/n
address:
name:Instituto de Neurociencias (CSIC-UMH) Avda Ramon y Cajal s/n, Sant Joan d´Alacant, Spain
type:PostalAddress
type:Organization
name:Alain Puisieux
url:http://orcid.org/0000-0002-9938-3798
affiliation:
name:Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Cancer Research Center of Lyon
address:
name:Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Cancer Research Center of Lyon, Lyon, France
type:PostalAddress
type:Organization
name:Institut Curie, PSL Research University
address:
name:Institut Curie, PSL Research University, Paris, France
type:PostalAddress
type:Organization
name:Raymond Runyan
url:http://orcid.org/0000-0002-7410-916X
affiliation:
name:University of Arizona
address:
name:Department of Cellular and Molecular Medicine, University of Arizona, Tucson, USA
type:PostalAddress
type:Organization
name:Pierre Savagner
affiliation:
name:University Paris-Saclay
address:
name:INSERM UMR 1186, Integrative Tumor Immunology and Genetic Oncology, Gustave Roussy, University Paris-Saclay, Villejuif, France
type:PostalAddress
type:Organization
name:Ben Stanger
affiliation:
name:University of Pennsylvania
address:
name:Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA
type:PostalAddress
type:Organization
name:Marc P. Stemmler
url:http://orcid.org/0000-0002-7866-3686
affiliation:
name:Friedrich-Alexander-University Erlangen-Nürnberg
address:
name:Department of Experimental Medicine 1, Nikolaus-Fiebiger-Center for Molecular Medicine, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany
type:PostalAddress
type:Organization
name:Yoshiko Takahashi
affiliation:
name:Kyoto University
address:
name:Department of Zoology, Graduate School of Science, Kyoto University, Kyoto, Japan
type:PostalAddress
type:Organization
name:Masatoshi Takeichi
url:http://orcid.org/0000-0002-9931-3378
affiliation:
name:RIKEN Center for Biosystems Dynamics Research
address:
name:RIKEN Center for Biosystems Dynamics Research, Kobe, Japan
type:PostalAddress
type:Organization
name:Eric Theveneau
url:http://orcid.org/0000-0001-6510-5717
affiliation:
name:Centre de Biologie du Développement (CBD), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS
address:
name:Centre de Biologie du Développement (CBD), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, Toulouse, France
type:PostalAddress
type:Organization
name:Jean Paul Thiery
url:http://orcid.org/0000-0003-0478-5020
affiliation:
name:Guangzhou Regenerative Medicine and Health, Guangdong Laboratory
address:
name:Guangzhou Regenerative Medicine and Health, Guangdong Laboratory, Guangzhou, China
type:PostalAddress
type:Organization
name:Erik W. Thompson
url:http://orcid.org/0000-0002-9723-4924
affiliation:
name:Queensland University of Technology, Translational Research Institute
address:
name:School of Biomedical Sciences and Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Woolloongabba, Australia
type:PostalAddress
type:Organization
name:Robert A. Weinberg
affiliation:
name:MIT Ludwig Center for Molecular Oncology, Massachusetts Institute of Technology
address:
name:Whitehead Institute for Biomedical Research, Department of Biology, MIT Ludwig Center for Molecular Oncology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
name:Elizabeth D. Williams
url:http://orcid.org/0000-0002-3364-6655
affiliation:
name:Queensland University of Technology
address:
name:Australian Prostate Cancer Research Centre-Queensland (APCRC-Q) and Queensland Bladder Cancer Initiative (QBCI), School of Biomedical Sciences and Institute of Health and Biomedical Innovation, Queensland University of Technology, Woolloongabba, Australia
type:PostalAddress
type:Organization
name:Jianhua Xing
url:http://orcid.org/0000-0002-3700-8765
affiliation:
name:University of Pittsburgh
address:
name:Department of Computational and Systems Biology and UPMC-Hillman Cancer Center, University of Pittsburgh, Pittsburgh, USA
type:PostalAddress
type:Organization
name:Binhua P. Zhou
affiliation:
name:University of Kentucky College of Medicine
address:
name:Department of Molecular and Cellular Biochemistry and UK Markey Cancer Center, University of Kentucky College of Medicine, Lexington, USA
type:PostalAddress
type:Organization
name:Guojun Sheng
affiliation:
name:Kumamoto University
address:
name:International Research Center for Medical Sciences (IRCMS), Kumamoto University, Kumamoto, Japan
type:PostalAddress
type:Organization
email:[email protected]
PostalAddress:
name:Departments of Pharmacology and Pediatrics, Moores Cancer Center, University of California, San Diego, La Jolla, USA
name:Department of Cellular and Molecular Medicine, University of Arizona, Tucson, USA
name:Molecular and Cellular Oncology Lab, Department of Biomedical Molecular Biology, Ghent University, Cancer Research Institute Ghent (CRIG), VIB Center for Inflammation Research, Ghent, Belgium
name:Laboratory of Stem Cells and Cancer, Université Libre de Bruxelles, Bruxelles, Belgium
name:Department of Experimental Medicine 1, Nikolaus-Fiebiger-Center for Molecular Medicine, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany
name:Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, USA
name:Department of Biomedical Science and Bateson Centre, University of Sheffield, Sheffield, UK
name:Departamento de BioquÃmica, Universidad Autónoma de Madrid (UAM), Instituto de Investigaciones Biomédicas âAlberto Solsâ (CSIC-UAM), IdiPAZ & Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain
name:Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology/Institut de Biologia Molecular de Barcelona (IBMB-CSIC), Barcelona, Spain
name:Department of Biomedicine, University of Basel, Basel, Switzerland
name:Department of Biochemistry and Molecular Biology, University of British Columbia and British Columbia Cancer Research Centre, Vancouver, Canada
name:Departments of Cell and Tissue Biology, and Anatomy, University of California at San Francisco, San Francisco, USA
name:Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, USA
name:Department of Laboratory Medicine (LABMED), Division of Pathology, Karolinska University Hospital and Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden
name:Programa de Recerca en Cà ncer, Institut Hospital del Mar dâInvestigacions Mèdiques (IMIM) and Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
name:Centre for Cancer Biology, An alliance of SA Pathology and University of South Australia, Adelaide, Australia
name:Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, USA
name:School of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
name:Department of Medical Neurobiology, Institute for medical Research Israel-Canada and the Safra Center for Neurosciences, Hebrew University of Jerusalem, Hadassah Medical School, Jerusalem, Israel
name:Department of Cancer Biology, Metastasis Research Center, MD Anderson Cancer Center, Houston, USA
name:Department of Molecular Biology, Princeton University, Princeton, USA
name:Centre for Cancer Biology, an Alliance of SA Pathology and the University of South Australia, Adelaide, Australia
name:Department of Physics, Northeastern University, Boston, USA
name:Department of Anatomic Pathology, The Division of Pathology and Laboratory Medicine, University of Texas MD Anderson Cancer Center, Houston, USA
name:Department of Medicine (Oncology) and Department of Cell Biology and Physiology, ICCE Institute, Washington University, St. Louis, USA
name:Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, USA
name:Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, USA
name:Department of Cell and Developmental Biology, University College London, London, UK
name:Department of Biology, Duke University, Durham, USA
name:Departments of Anatomy and Biochemistry/Biophysics, University of California, San Francisco, School of Medicine, San Francisco, USA
name:Murdoch Childrenâs Research Institute, Royal Childrenâs Hospital, Parkville, Australia
name:Instituto de Neurociencias (CSIC-UMH) Avda Ramon y Cajal s/n, Sant Joan d´Alacant, Spain
name:Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Cancer Research Center of Lyon, Lyon, France
name:Institut Curie, PSL Research University, Paris, France
name:Department of Cellular and Molecular Medicine, University of Arizona, Tucson, USA
name:INSERM UMR 1186, Integrative Tumor Immunology and Genetic Oncology, Gustave Roussy, University Paris-Saclay, Villejuif, France
name:Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA
name:Department of Experimental Medicine 1, Nikolaus-Fiebiger-Center for Molecular Medicine, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany
name:Department of Zoology, Graduate School of Science, Kyoto University, Kyoto, Japan
name:RIKEN Center for Biosystems Dynamics Research, Kobe, Japan
name:Centre de Biologie du Développement (CBD), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, Toulouse, France
name:Guangzhou Regenerative Medicine and Health, Guangdong Laboratory, Guangzhou, China
name:School of Biomedical Sciences and Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Woolloongabba, Australia
name:Whitehead Institute for Biomedical Research, Department of Biology, MIT Ludwig Center for Molecular Oncology, Massachusetts Institute of Technology, Cambridge, USA
name:Australian Prostate Cancer Research Centre-Queensland (APCRC-Q) and Queensland Bladder Cancer Initiative (QBCI), School of Biomedical Sciences and Institute of Health and Biomedical Innovation, Queensland University of Technology, Woolloongabba, Australia
name:Department of Computational and Systems Biology and UPMC-Hillman Cancer Center, University of Pittsburgh, Pittsburgh, USA
name:Department of Molecular and Cellular Biochemistry and UK Markey Cancer Center, University of Kentucky College of Medicine, Lexington, USA
name:International Research Center for Medical Sciences (IRCMS), Kumamoto University, Kumamoto, Japan
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- https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=C%C3%A9dric%20Blanpain's financial summary
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- What's the monthly money flow for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Anna-Katerina%20Hadjantonakis?
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- How much income is https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Sendurai%20A.%20Mani%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en earning monthly?
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- https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Roberto%20Mayor income
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- https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Raymond%20Runyan's financial summary
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