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We are analyzing https://www.nature.com/articles/s41580-020-0237-9.

Title:
Guidelines and definitions for research on epithelial–mesenchymal transition | Nature Reviews Molecular Cell Biology
Description:
Epithelial–mesenchymal transition (EMT) encompasses dynamic changes in cellular organization from epithelial to mesenchymal phenotypes, which leads to functional changes in cell migration and invasion. EMT occurs in a diverse range of physiological and pathological conditions and is driven by a conserved set of inducing signals, transcriptional regulators and downstream effectors. With over 5,700 publications indexed by Web of Science in 2019 alone, research on EMT is expanding rapidly. This growing interest warrants the need for a consensus among researchers when referring to and undertaking research on EMT. This Consensus Statement, mediated by ‘the EMT International Association’ (TEMTIA), is the outcome of a 2-year-long discussion among EMT researchers and aims to both clarify the nomenclature and provide definitions and guidelines for EMT research in future publications. We trust that these guidelines will help to reduce misunderstanding and misinterpretation of research data generated in various experimental models and to promote cross-disciplinary collaboration to identify and address key open questions in this research field. While recognizing the importance of maintaining diversity in experimental approaches and conceptual frameworks, we emphasize that lasting contributions of EMT research to increasing our understanding of developmental processes and combatting cancer and other diseases depend on the adoption of a unified terminology to describe EMT. In this Consensus Statement, the authors (on behalf of the EMT International Association) propose guidelines to define epithelial–mesenchymal transition, its phenotypic plasticity and the associated multiple intermediate epithelial–mesenchymal cell states. Clarification of nomenclature and definitions will help reduce misinterpretation of research data generated in different experimental model systems and promote cross-disciplinary collaboration.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

  • Science
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Custom-built

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🌆 Monumental Traffic: 20M - 50M visitors per month


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$521,200 per month
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Keywords {🔍}

emt, cells, pubmed, cell, article, epithelial, google, scholar, cancer, cas, mesenchymal, development, research, epithelialmesenchymal, molecular, transition, central, nature, junctions, university, plasticity, expression, biology, cellular, metastasis, states, biol, emttfs, markers, department, usa, fibrosis, diverse, developmental, programmes, polarity, factors, nat, migration, transcription, biological, studies, tumour, intermediate, state, cellcell, tissue, gene, phenotypic, phenotypes,

Topics {✒️}

nature portfolio privacy policy advertising polyomavirus middle t-antigen myosin-ii-mediated cell shape antonio garcía de herreros researcher experts friedrich-alexander-university erlangen-nürnberg social media zinc-finger protein slug consensus statement article cadherin-based cell–cell contacts reprints promote cross-disciplinary collaboration zinc finger/homeodomain repressor regional open question zinc-finger transcription factors medical research israel-canada apical–basal polarity guides research data generated tgf-β induced transdifferentiation central issue upmc-hillman cancer center nature nature 527 nature 547 nature 216 nature 372 nature 556 nature 472 nature 330 par-complex-mediated snai1 degradation enable cross-disciplinary collaborations cadherin-mediated homophilic interactions gene encoding e-cadherin25 acquire apical–basal polarity mesenchymal pre-somitic mesoderm tubular epithelial–mesenchymal transition repressing e-cadherin expression mediate cell–cell interactions operative cell–cell interactions zinc finger gene control cell–cell adhesion complex post-translational modifications original author permissions apical-lateral contact points epithelial–mesenchymal plasticity model subsequent lineage-tracing analyses

Questions {❓}

  • Carcinoma invasion and metastasis: a role for epithelial–mesenchymal transition?
  • Epithelial–mesenchymal transition (EMT) and metastasis: yes, no, maybe?
  • Establishment of epithelial polarity–GEF who’s minding the GAP?
  • The relevance of EMT in breast cancer metastasis: correlation or causality?

Schema {🗺️}

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         headline:Guidelines and definitions for research on epithelial–mesenchymal transition
         description:Epithelial–mesenchymal transition (EMT) encompasses dynamic changes in cellular organization from epithelial to mesenchymal phenotypes, which leads to functional changes in cell migration and invasion. EMT occurs in a diverse range of physiological and pathological conditions and is driven by a conserved set of inducing signals, transcriptional regulators and downstream effectors. With over 5,700 publications indexed by Web of Science in 2019 alone, research on EMT is expanding rapidly. This growing interest warrants the need for a consensus among researchers when referring to and undertaking research on EMT. This Consensus Statement, mediated by ‘the EMT International Association’ (TEMTIA), is the outcome of a 2-year-long discussion among EMT researchers and aims to both clarify the nomenclature and provide definitions and guidelines for EMT research in future publications. We trust that these guidelines will help to reduce misunderstanding and misinterpretation of research data generated in various experimental models and to promote cross-disciplinary collaboration to identify and address key open questions in this research field. While recognizing the importance of maintaining diversity in experimental approaches and conceptual frameworks, we emphasize that lasting contributions of EMT research to increasing our understanding of developmental processes and combatting cancer and other diseases depend on the adoption of a unified terminology to describe EMT. In this Consensus Statement, the authors (on behalf of the EMT International Association) propose guidelines to define epithelial–mesenchymal transition, its phenotypic plasticity and the associated multiple intermediate epithelial–mesenchymal cell states. Clarification of nomenclature and definitions will help reduce misinterpretation of research data generated in different experimental model systems and promote cross-disciplinary collaboration.
         datePublished:2020-04-16T00:00:00Z
         dateModified:2021-10-15T00:00:00Z
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            Cancer
            Developmental biology
            Epithelial–mesenchymal transition
            Life Sciences
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            Cancer Research
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            Stem Cells
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      headline:Guidelines and definitions for research on epithelial–mesenchymal transition
      description:Epithelial–mesenchymal transition (EMT) encompasses dynamic changes in cellular organization from epithelial to mesenchymal phenotypes, which leads to functional changes in cell migration and invasion. EMT occurs in a diverse range of physiological and pathological conditions and is driven by a conserved set of inducing signals, transcriptional regulators and downstream effectors. With over 5,700 publications indexed by Web of Science in 2019 alone, research on EMT is expanding rapidly. This growing interest warrants the need for a consensus among researchers when referring to and undertaking research on EMT. This Consensus Statement, mediated by ‘the EMT International Association’ (TEMTIA), is the outcome of a 2-year-long discussion among EMT researchers and aims to both clarify the nomenclature and provide definitions and guidelines for EMT research in future publications. We trust that these guidelines will help to reduce misunderstanding and misinterpretation of research data generated in various experimental models and to promote cross-disciplinary collaboration to identify and address key open questions in this research field. While recognizing the importance of maintaining diversity in experimental approaches and conceptual frameworks, we emphasize that lasting contributions of EMT research to increasing our understanding of developmental processes and combatting cancer and other diseases depend on the adoption of a unified terminology to describe EMT. In this Consensus Statement, the authors (on behalf of the EMT International Association) propose guidelines to define epithelial–mesenchymal transition, its phenotypic plasticity and the associated multiple intermediate epithelial–mesenchymal cell states. Clarification of nomenclature and definitions will help reduce misinterpretation of research data generated in different experimental model systems and promote cross-disciplinary collaboration.
      datePublished:2020-04-16T00:00:00Z
      dateModified:2021-10-15T00:00:00Z
      pageStart:341
      pageEnd:352
      license:http://creativecommons.org/licenses/by/4.0/
      sameAs:https://doi.org/10.1038/s41580-020-0237-9
      keywords:
         Cancer
         Developmental biology
         Epithelial–mesenchymal transition
         Life Sciences
         general
         Cell Biology
         Cancer Research
         Developmental Biology
         Stem Cells
         Biochemistry
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      name:University of Texas MD Anderson Cancer Center
      address:
         name:Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, USA
         type:PostalAddress
      name:Memorial Sloan Kettering Cancer Center
      address:
         name:Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, USA
         type:PostalAddress
      name:University College London
      address:
         name:Department of Cell and Developmental Biology, University College London, London, UK
         type:PostalAddress
      name:Duke University
      address:
         name:Department of Biology, Duke University, Durham, USA
         type:PostalAddress
      name:University of California, San Francisco, School of Medicine
      address:
         name:Departments of Anatomy and Biochemistry/Biophysics, University of California, San Francisco, School of Medicine, San Francisco, USA
         type:PostalAddress
      name:Murdoch Children’s Research Institute, Royal Children’s Hospital
      address:
         name:Murdoch Children’s Research Institute, Royal Children’s Hospital, Parkville, Australia
         type:PostalAddress
      name:Instituto de Neurociencias (CSIC-UMH) Avda Ramon y Cajal s/n
      address:
         name:Instituto de Neurociencias (CSIC-UMH) Avda Ramon y Cajal s/n, Sant Joan d´Alacant, Spain
         type:PostalAddress
      name:Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Cancer Research Center of Lyon
      address:
         name:Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Cancer Research Center of Lyon, Lyon, France
         type:PostalAddress
      name:Institut Curie, PSL Research University
      address:
         name:Institut Curie, PSL Research University, Paris, France
         type:PostalAddress
      name:University of Arizona
      address:
         name:Department of Cellular and Molecular Medicine, University of Arizona, Tucson, USA
         type:PostalAddress
      name:University Paris-Saclay
      address:
         name:INSERM UMR 1186, Integrative Tumor Immunology and Genetic Oncology, Gustave Roussy, University Paris-Saclay, Villejuif, France
         type:PostalAddress
      name:University of Pennsylvania
      address:
         name:Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA
         type:PostalAddress
      name:Friedrich-Alexander-University Erlangen-Nürnberg
      address:
         name:Department of Experimental Medicine 1, Nikolaus-Fiebiger-Center for Molecular Medicine, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany
         type:PostalAddress
      name:Kyoto University
      address:
         name:Department of Zoology, Graduate School of Science, Kyoto University, Kyoto, Japan
         type:PostalAddress
      name:RIKEN Center for Biosystems Dynamics Research
      address:
         name:RIKEN Center for Biosystems Dynamics Research, Kobe, Japan
         type:PostalAddress
      name:Centre de Biologie du Développement (CBD), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS
      address:
         name:Centre de Biologie du Développement (CBD), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, Toulouse, France
         type:PostalAddress
      name:Guangzhou Regenerative Medicine and Health, Guangdong Laboratory
      address:
         name:Guangzhou Regenerative Medicine and Health, Guangdong Laboratory, Guangzhou, China
         type:PostalAddress
      name:Queensland University of Technology, Translational Research Institute
      address:
         name:School of Biomedical Sciences and Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Woolloongabba, Australia
         type:PostalAddress
      name:MIT Ludwig Center for Molecular Oncology, Massachusetts Institute of Technology
      address:
         name:Whitehead Institute for Biomedical Research, Department of Biology, MIT Ludwig Center for Molecular Oncology, Massachusetts Institute of Technology, Cambridge, USA
         type:PostalAddress
      name:Queensland University of Technology
      address:
         name:Australian Prostate Cancer Research Centre-Queensland (APCRC-Q) and Queensland Bladder Cancer Initiative (QBCI), School of Biomedical Sciences and Institute of Health and Biomedical Innovation, Queensland University of Technology, Woolloongabba, Australia
         type:PostalAddress
      name:University of Pittsburgh
      address:
         name:Department of Computational and Systems Biology and UPMC-Hillman Cancer Center, University of Pittsburgh, Pittsburgh, USA
         type:PostalAddress
      name:University of Kentucky College of Medicine
      address:
         name:Department of Molecular and Cellular Biochemistry and UK Markey Cancer Center, University of Kentucky College of Medicine, Lexington, USA
         type:PostalAddress
      name:Kumamoto University
      address:
         name:International Research Center for Medical Sciences (IRCMS), Kumamoto University, Kumamoto, Japan
         type:PostalAddress
ImageObject:
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      name:Jing Yang
      url:http://orcid.org/0000-0001-8410-3549
      affiliation:
            name:University of California, San Diego
            address:
               name:Departments of Pharmacology and Pediatrics, Moores Cancer Center, University of California, San Diego, La Jolla, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Parker Antin
      affiliation:
            name:University of Arizona
            address:
               name:Department of Cellular and Molecular Medicine, University of Arizona, Tucson, USA
               type:PostalAddress
            type:Organization
      name:Geert Berx
      affiliation:
            name:Ghent University, Cancer Research Institute Ghent (CRIG), VIB Center for Inflammation Research
            address:
               name:Molecular and Cellular Oncology Lab, Department of Biomedical Molecular Biology, Ghent University, Cancer Research Institute Ghent (CRIG), VIB Center for Inflammation Research, Ghent, Belgium
               type:PostalAddress
            type:Organization
      name:Cédric Blanpain
      affiliation:
            name:Université Libre de Bruxelles
            address:
               name:Laboratory of Stem Cells and Cancer, Université Libre de Bruxelles, Bruxelles, Belgium
               type:PostalAddress
            type:Organization
      name:Thomas Brabletz
      affiliation:
            name:Friedrich-Alexander-University Erlangen-Nürnberg
            address:
               name:Department of Experimental Medicine 1, Nikolaus-Fiebiger-Center for Molecular Medicine, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany
               type:PostalAddress
            type:Organization
      name:Marianne Bronner
      affiliation:
            name:California Institute of Technology
            address:
               name:Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, USA
               type:PostalAddress
            type:Organization
      name:Kyra Campbell
      affiliation:
            name:University of Sheffield
            address:
               name:Department of Biomedical Science and Bateson Centre, University of Sheffield, Sheffield, UK
               type:PostalAddress
            type:Organization
      name:Amparo Cano
      affiliation:
            name:Universidad Autónoma de Madrid (UAM), Instituto de Investigaciones Biomédicas ‘Alberto Sols’ (CSIC-UAM), IdiPAZ & Centro de Investigación Biomédica en Red de Cáncer (CIBERONC)
            address:
               name:Departamento de Bioquímica, Universidad Autónoma de Madrid (UAM), Instituto de Investigaciones Biomédicas ‘Alberto Sols’ (CSIC-UAM), IdiPAZ & Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain
               type:PostalAddress
            type:Organization
      name:Jordi Casanova
      affiliation:
            name:Barcelona Institute of Science and Technology/Institut de Biologia Molecular de Barcelona (IBMB-CSIC)
            address:
               name:Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology/Institut de Biologia Molecular de Barcelona (IBMB-CSIC), Barcelona, Spain
               type:PostalAddress
            type:Organization
      name:Gerhard Christofori
      affiliation:
            name:University of Basel
            address:
               name:Department of Biomedicine, University of Basel, Basel, Switzerland
               type:PostalAddress
            type:Organization
      name:Shoukat Dedhar
      affiliation:
            name:University of British Columbia and British Columbia Cancer Research Centre
            address:
               name:Department of Biochemistry and Molecular Biology, University of British Columbia and British Columbia Cancer Research Centre, Vancouver, Canada
               type:PostalAddress
            type:Organization
      name:Rik Derynck
      affiliation:
            name:University of California at San Francisco
            address:
               name:Departments of Cell and Tissue Biology, and Anatomy, University of California at San Francisco, San Francisco, USA
               type:PostalAddress
            type:Organization
      name:Heide L. Ford
      affiliation:
            name:University of Colorado Anschutz Medical Campus
            address:
               name:Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, USA
               type:PostalAddress
            type:Organization
      name:Jonas Fuxe
      url:http://orcid.org/0000-0003-4576-9377
      affiliation:
            name:Karolinska University Hospital and Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet
            address:
               name:Department of Laboratory Medicine (LABMED), Division of Pathology, Karolinska University Hospital and Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden
               type:PostalAddress
            type:Organization
      name:Antonio García de Herreros
      affiliation:
            name:Universitat Pompeu Fabra
            address:
               name:Programa de Recerca en Càncer, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM) and Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
               type:PostalAddress
            type:Organization
      name:Gregory J. Goodall
      affiliation:
            name:An alliance of SA Pathology and University of South Australia
            address:
               name:Centre for Cancer Biology, An alliance of SA Pathology and University of South Australia, Adelaide, Australia
               type:PostalAddress
            type:Organization
      name:Anna-Katerina Hadjantonakis
      affiliation:
            name:Memorial Sloan Kettering Cancer Center
            address:
               name:Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, USA
               type:PostalAddress
            type:Organization
      name:Ruby Y. J. Huang
      affiliation:
            name:National Taiwan University
            address:
               name:School of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
               type:PostalAddress
            type:Organization
      name:Chaya Kalcheim
      affiliation:
            name:Hebrew University of Jerusalem, Hadassah Medical School
            address:
               name:Department of Medical Neurobiology, Institute for medical Research Israel-Canada and the Safra Center for Neurosciences, Hebrew University of Jerusalem, Hadassah Medical School, Jerusalem, Israel
               type:PostalAddress
            type:Organization
      name:Raghu Kalluri
      affiliation:
            name:Metastasis Research Center, MD Anderson Cancer Center
            address:
               name:Department of Cancer Biology, Metastasis Research Center, MD Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
      name:Yibin Kang
      url:http://orcid.org/0000-0002-1626-6730
      affiliation:
            name:Princeton University
            address:
               name:Department of Molecular Biology, Princeton University, Princeton, USA
               type:PostalAddress
            type:Organization
      name:Yeesim Khew-Goodall
      affiliation:
            name:an Alliance of SA Pathology and the University of South Australia
            address:
               name:Centre for Cancer Biology, an Alliance of SA Pathology and the University of South Australia, Adelaide, Australia
               type:PostalAddress
            type:Organization
      name:Herbert Levine
      affiliation:
            name:Northeastern University
            address:
               name:Department of Physics, Northeastern University, Boston, USA
               type:PostalAddress
            type:Organization
      name:Jinsong Liu
      affiliation:
            name:University of Texas MD Anderson Cancer Center
            address:
               name:Department of Anatomic Pathology, The Division of Pathology and Laboratory Medicine, University of Texas MD Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
      name:Gregory D. Longmore
      affiliation:
            name:ICCE Institute, Washington University
            address:
               name:Department of Medicine (Oncology) and Department of Cell Biology and Physiology, ICCE Institute, Washington University, St. Louis, USA
               type:PostalAddress
            type:Organization
      name:Sendurai A. Mani
      affiliation:
            name:University of Texas MD Anderson Cancer Center
            address:
               name:Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
      name:Joan Massagué
      affiliation:
            name:Memorial Sloan Kettering Cancer Center
            address:
               name:Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, USA
               type:PostalAddress
            type:Organization
      name:Roberto Mayor
      url:http://orcid.org/0000-0001-9053-9613
      affiliation:
            name:University College London
            address:
               name:Department of Cell and Developmental Biology, University College London, London, UK
               type:PostalAddress
            type:Organization
      name:David McClay
      affiliation:
            name:Duke University
            address:
               name:Department of Biology, Duke University, Durham, USA
               type:PostalAddress
            type:Organization
      name:Keith E. Mostov
      url:http://orcid.org/0000-0002-8123-6247
      affiliation:
            name:University of California, San Francisco, School of Medicine
            address:
               name:Departments of Anatomy and Biochemistry/Biophysics, University of California, San Francisco, School of Medicine, San Francisco, USA
               type:PostalAddress
            type:Organization
      name:Donald F. Newgreen
      url:http://orcid.org/0000-0002-3467-6389
      affiliation:
            name:Murdoch Children’s Research Institute, Royal Children’s Hospital
            address:
               name:Murdoch Children’s Research Institute, Royal Children’s Hospital, Parkville, Australia
               type:PostalAddress
            type:Organization
      name:M. Angela Nieto
      url:http://orcid.org/0000-0002-3538-840X
      affiliation:
            name:Instituto de Neurociencias (CSIC-UMH) Avda Ramon y Cajal s/n
            address:
               name:Instituto de Neurociencias (CSIC-UMH) Avda Ramon y Cajal s/n, Sant Joan d´Alacant, Spain
               type:PostalAddress
            type:Organization
      name:Alain Puisieux
      url:http://orcid.org/0000-0002-9938-3798
      affiliation:
            name:Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Cancer Research Center of Lyon
            address:
               name:Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Cancer Research Center of Lyon, Lyon, France
               type:PostalAddress
            type:Organization
            name:Institut Curie, PSL Research University
            address:
               name:Institut Curie, PSL Research University, Paris, France
               type:PostalAddress
            type:Organization
      name:Raymond Runyan
      url:http://orcid.org/0000-0002-7410-916X
      affiliation:
            name:University of Arizona
            address:
               name:Department of Cellular and Molecular Medicine, University of Arizona, Tucson, USA
               type:PostalAddress
            type:Organization
      name:Pierre Savagner
      affiliation:
            name:University Paris-Saclay
            address:
               name:INSERM UMR 1186, Integrative Tumor Immunology and Genetic Oncology, Gustave Roussy, University Paris-Saclay, Villejuif, France
               type:PostalAddress
            type:Organization
      name:Ben Stanger
      affiliation:
            name:University of Pennsylvania
            address:
               name:Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA
               type:PostalAddress
            type:Organization
      name:Marc P. Stemmler
      url:http://orcid.org/0000-0002-7866-3686
      affiliation:
            name:Friedrich-Alexander-University Erlangen-Nürnberg
            address:
               name:Department of Experimental Medicine 1, Nikolaus-Fiebiger-Center for Molecular Medicine, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany
               type:PostalAddress
            type:Organization
      name:Yoshiko Takahashi
      affiliation:
            name:Kyoto University
            address:
               name:Department of Zoology, Graduate School of Science, Kyoto University, Kyoto, Japan
               type:PostalAddress
            type:Organization
      name:Masatoshi Takeichi
      url:http://orcid.org/0000-0002-9931-3378
      affiliation:
            name:RIKEN Center for Biosystems Dynamics Research
            address:
               name:RIKEN Center for Biosystems Dynamics Research, Kobe, Japan
               type:PostalAddress
            type:Organization
      name:Eric Theveneau
      url:http://orcid.org/0000-0001-6510-5717
      affiliation:
            name:Centre de Biologie du Développement (CBD), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS
            address:
               name:Centre de Biologie du Développement (CBD), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, Toulouse, France
               type:PostalAddress
            type:Organization
      name:Jean Paul Thiery
      url:http://orcid.org/0000-0003-0478-5020
      affiliation:
            name:Guangzhou Regenerative Medicine and Health, Guangdong Laboratory
            address:
               name:Guangzhou Regenerative Medicine and Health, Guangdong Laboratory, Guangzhou, China
               type:PostalAddress
            type:Organization
      name:Erik W. Thompson
      url:http://orcid.org/0000-0002-9723-4924
      affiliation:
            name:Queensland University of Technology, Translational Research Institute
            address:
               name:School of Biomedical Sciences and Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Woolloongabba, Australia
               type:PostalAddress
            type:Organization
      name:Robert A. Weinberg
      affiliation:
            name:MIT Ludwig Center for Molecular Oncology, Massachusetts Institute of Technology
            address:
               name:Whitehead Institute for Biomedical Research, Department of Biology, MIT Ludwig Center for Molecular Oncology, Massachusetts Institute of Technology, Cambridge, USA
               type:PostalAddress
            type:Organization
      name:Elizabeth D. Williams
      url:http://orcid.org/0000-0002-3364-6655
      affiliation:
            name:Queensland University of Technology
            address:
               name:Australian Prostate Cancer Research Centre-Queensland (APCRC-Q) and Queensland Bladder Cancer Initiative (QBCI), School of Biomedical Sciences and Institute of Health and Biomedical Innovation, Queensland University of Technology, Woolloongabba, Australia
               type:PostalAddress
            type:Organization
      name:Jianhua Xing
      url:http://orcid.org/0000-0002-3700-8765
      affiliation:
            name:University of Pittsburgh
            address:
               name:Department of Computational and Systems Biology and UPMC-Hillman Cancer Center, University of Pittsburgh, Pittsburgh, USA
               type:PostalAddress
            type:Organization
      name:Binhua P. Zhou
      affiliation:
            name:University of Kentucky College of Medicine
            address:
               name:Department of Molecular and Cellular Biochemistry and UK Markey Cancer Center, University of Kentucky College of Medicine, Lexington, USA
               type:PostalAddress
            type:Organization
      name:Guojun Sheng
      affiliation:
            name:Kumamoto University
            address:
               name:International Research Center for Medical Sciences (IRCMS), Kumamoto University, Kumamoto, Japan
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Departments of Pharmacology and Pediatrics, Moores Cancer Center, University of California, San Diego, La Jolla, USA
      name:Department of Cellular and Molecular Medicine, University of Arizona, Tucson, USA
      name:Molecular and Cellular Oncology Lab, Department of Biomedical Molecular Biology, Ghent University, Cancer Research Institute Ghent (CRIG), VIB Center for Inflammation Research, Ghent, Belgium
      name:Laboratory of Stem Cells and Cancer, Université Libre de Bruxelles, Bruxelles, Belgium
      name:Department of Experimental Medicine 1, Nikolaus-Fiebiger-Center for Molecular Medicine, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany
      name:Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, USA
      name:Department of Biomedical Science and Bateson Centre, University of Sheffield, Sheffield, UK
      name:Departamento de Bioquímica, Universidad Autónoma de Madrid (UAM), Instituto de Investigaciones Biomédicas ‘Alberto Sols’ (CSIC-UAM), IdiPAZ & Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain
      name:Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology/Institut de Biologia Molecular de Barcelona (IBMB-CSIC), Barcelona, Spain
      name:Department of Biomedicine, University of Basel, Basel, Switzerland
      name:Department of Biochemistry and Molecular Biology, University of British Columbia and British Columbia Cancer Research Centre, Vancouver, Canada
      name:Departments of Cell and Tissue Biology, and Anatomy, University of California at San Francisco, San Francisco, USA
      name:Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, USA
      name:Department of Laboratory Medicine (LABMED), Division of Pathology, Karolinska University Hospital and Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden
      name:Programa de Recerca en Càncer, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM) and Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
      name:Centre for Cancer Biology, An alliance of SA Pathology and University of South Australia, Adelaide, Australia
      name:Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, USA
      name:School of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
      name:Department of Medical Neurobiology, Institute for medical Research Israel-Canada and the Safra Center for Neurosciences, Hebrew University of Jerusalem, Hadassah Medical School, Jerusalem, Israel
      name:Department of Cancer Biology, Metastasis Research Center, MD Anderson Cancer Center, Houston, USA
      name:Department of Molecular Biology, Princeton University, Princeton, USA
      name:Centre for Cancer Biology, an Alliance of SA Pathology and the University of South Australia, Adelaide, Australia
      name:Department of Physics, Northeastern University, Boston, USA
      name:Department of Anatomic Pathology, The Division of Pathology and Laboratory Medicine, University of Texas MD Anderson Cancer Center, Houston, USA
      name:Department of Medicine (Oncology) and Department of Cell Biology and Physiology, ICCE Institute, Washington University, St. Louis, USA
      name:Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, USA
      name:Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, USA
      name:Department of Cell and Developmental Biology, University College London, London, UK
      name:Department of Biology, Duke University, Durham, USA
      name:Departments of Anatomy and Biochemistry/Biophysics, University of California, San Francisco, School of Medicine, San Francisco, USA
      name:Murdoch Children’s Research Institute, Royal Children’s Hospital, Parkville, Australia
      name:Instituto de Neurociencias (CSIC-UMH) Avda Ramon y Cajal s/n, Sant Joan d´Alacant, Spain
      name:Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Cancer Research Center of Lyon, Lyon, France
      name:Institut Curie, PSL Research University, Paris, France
      name:Department of Cellular and Molecular Medicine, University of Arizona, Tucson, USA
      name:INSERM UMR 1186, Integrative Tumor Immunology and Genetic Oncology, Gustave Roussy, University Paris-Saclay, Villejuif, France
      name:Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA
      name:Department of Experimental Medicine 1, Nikolaus-Fiebiger-Center for Molecular Medicine, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany
      name:Department of Zoology, Graduate School of Science, Kyoto University, Kyoto, Japan
      name:RIKEN Center for Biosystems Dynamics Research, Kobe, Japan
      name:Centre de Biologie du Développement (CBD), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, Toulouse, France
      name:Guangzhou Regenerative Medicine and Health, Guangdong Laboratory, Guangzhou, China
      name:School of Biomedical Sciences and Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Woolloongabba, Australia
      name:Whitehead Institute for Biomedical Research, Department of Biology, MIT Ludwig Center for Molecular Oncology, Massachusetts Institute of Technology, Cambridge, USA
      name:Australian Prostate Cancer Research Centre-Queensland (APCRC-Q) and Queensland Bladder Cancer Initiative (QBCI), School of Biomedical Sciences and Institute of Health and Biomedical Innovation, Queensland University of Technology, Woolloongabba, Australia
      name:Department of Computational and Systems Biology and UPMC-Hillman Cancer Center, University of Pittsburgh, Pittsburgh, USA
      name:Department of Molecular and Cellular Biochemistry and UK Markey Cancer Center, University of Kentucky College of Medicine, Lexington, USA
      name:International Research Center for Medical Sciences (IRCMS), Kumamoto University, Kumamoto, Japan

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