We are analyzing https://link.springer.com/article/10.1007/bf00304424.

Title:
Early stages of chick somite development | Brain Structure and Function
Description:
We report on the formation and early differentiation of the somites in the avian embryo. The somites are derived from the mesoderm which, in the body (excluding the head), is subdivided into four compartments: the axial, paraxial, intermediate and lateral plate mesoderm. Somites develop from the paraxial mesoderm and constitute the segmental pattern of the body. They are formed in pairs by epithelialization, first at the cranial end of the paraxial mesoderm, proceeding caudally, while new mesenchyme cells enter the paraxial mesoderm as a consequence of gastrulation. After their formation, which depends upon cell-cell and cell-matrix interactions, the somites impose segmental pattern upon peripheral nerves and vascular primordia. The newly formed somite consists of an epithelial ball of columnar cells enveloping mesenchymal cells within a central cavity, the somitocoel. Each somite is surrounded by extracellular matrix material connecting the somite with adjacent structures. The competence to form skeletal muscle is a unique property of the somites and becomes realized during compartmentalization, under control of signals emanating from surrounding tissues. Compartmentalization is accompanied by altered patterns of expression of Pax genes within the somite. These are believed to be involved in the specification of somite cell lineages. Somites are also regionally specified, giving rise to particular skeletal structures at different axial levels. This axial specification appears to be reflected in Hox gene expression. MyoD is first expressed in the dorsomedial quadrant of the still epithelial somite whose cells are not yet definitely committed. During early maturation, the ventral wall of the somite undergoes an epithelio-mesenchymal transition forming the sclerotome. The sclerotome later becomes subdivided into rostral and caudal halves which are separated laterally by von Ebner
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Careers

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We don’t know how the website earns money.

Not all websites focus on profit; some are designed to educate, connect people, or share useful tools. People create websites for numerous reasons. And this could be one such example. Link.springer.com has a revenue plan, but it's either invisible or we haven't found it.

Keywords {🔍}

google, scholar, development, jacob, chick, embryol, christ, cells, somite, embryo, avian, anat, somites, exp, cell, biol, dev, morphol, embryos, mesoderm, early, formation, article, differentiation, expression, neural, myogenic, analysis, muscle, limb, migration, study, axial, sclerotome, crest, lash, ordahl, pax, specification, somitogenesis, determination, experimental, role, origin, wachtler, muscles, bellairs, wilting, notochord, entwicklung,

Topics {✒️}

t-cadherin expression alternatives month download article/chapter epithelio-mesenchymal transition forming yorde de de gruyter pair-rule gene expression vogel- und schafsembryonen primitive-streak stages ventro-lateral trunk musculature chick-quail chimaera model le douarin nm privacy choices/manage cookies epithelio-mesenchymal transition full article pdf extracellular matrix products cardiovascular research institute cell-matrix interactions myogenic stem cells primitive streak electron microscopic study neural crest cells experimentelle untersuchungen related subjects staging somites vertebrate nervous system early mesoderm differentiation extrinsic ocular muscles urlakis kj jr myogenic cell specification form skeletal muscle european economic area monoclonal antibody hnk-1 iiird international conference splotch mutation interferes georges labonesse en perinotochordal connective tissue coturnix coturnix japonica avian somatopleural mesoderm mesenchyme cells enter early endothelial cells endothelial cell lineages avian wolffian duct lateral plate mesoderm check access embryonic mesonephros expiants instant access axial specification appears freeze-etch study conditions privacy policy mac cabe ja

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Early stages of chick somite development
         description:We report on the formation and early differentiation of the somites in the avian embryo. The somites are derived from the mesoderm which, in the body (excluding the head), is subdivided into four compartments: the axial, paraxial, intermediate and lateral plate mesoderm. Somites develop from the paraxial mesoderm and constitute the segmental pattern of the body. They are formed in pairs by epithelialization, first at the cranial end of the paraxial mesoderm, proceeding caudally, while new mesenchyme cells enter the paraxial mesoderm as a consequence of gastrulation. After their formation, which depends upon cell-cell and cell-matrix interactions, the somites impose segmental pattern upon peripheral nerves and vascular primordia. The newly formed somite consists of an epithelial ball of columnar cells enveloping mesenchymal cells within a central cavity, the somitocoel. Each somite is surrounded by extracellular matrix material connecting the somite with adjacent structures. The competence to form skeletal muscle is a unique property of the somites and becomes realized during compartmentalization, under control of signals emanating from surrounding tissues. Compartmentalization is accompanied by altered patterns of expression of Pax genes within the somite. These are believed to be involved in the specification of somite cell lineages. Somites are also regionally specified, giving rise to particular skeletal structures at different axial levels. This axial specification appears to be reflected in Hox gene expression. MyoD is first expressed in the dorsomedial quadrant of the still epithelial somite whose cells are not yet definitely committed. During early maturation, the ventral wall of the somite undergoes an epithelio-mesenchymal transition forming the sclerotome. The sclerotome later becomes subdivided into rostral and caudal halves which are separated laterally by von Ebner's fissure. The lateral part of the caudal half of the sclerotome mainly forms the ribs, neural arches and pedicles of vertebrae, whereas within the lateral part of the rostral half the spinal nerve develops. The medially migrating sclerotomal cells form the peri-notochordal sheath, and later give rise to the vertebral bodies and intervertebral discs. The somitocoel cells also contribute to the sclerotome. The dorsal half of the somite remains epithelial and is referred to as the dermomyotome because it gives rise to the dermis of the back and the skeletal musculature. The cells located within the lateral half of the dermomyotome are the precursors of the muscles of the hypaxial domain of the body, whereas those in the medial half are precursors of the epaxial (back) muscles. Single epithelial cells at the cranio-medial edge of the dermomyotome elongate in a caudal direction, beneath the dermomyotome, and become anchored at its caudal margin. These post-mitotic and muscle protein-expressing cells form the myotome. At limb levels, the precursors of hypaxial muscles undergo an epithelio-mesenchymal transition and migrate into the somatic mesoderm, where they replicate and later differentiate. These cells express the Pax-3 gene prior to, during and after this migration. All compartments of the somite contribute endothelial cells to the formation of vascular primordia. These cells, unlike all other cells of the somite, occasionally cross the midline of the developing embryo. We also suggest a method for staging somites according to their developmental age.
         datePublished:
         dateModified:
         pageStart:381
         pageEnd:396
         sameAs:https://doi.org/10.1007/BF00304424
         keywords:
            Avian embryo
            Paraxial mesoderm
            Somite differentiation
            Cell specification
            Somite staging
            Neurosciences
            Cell Biology
            Neurology
         image:
         isPartOf:
            name:Anatomy and Embryology
            issn:
               1432-0568
               0340-2061
            volumeNumber:191
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer-Verlag
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Bodo Christ
               affiliation:
                     name:University of Freiburg
                     address:
                        name:Institute of Anatomy, University of Freiburg, Freiburg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Charles P. Ordahl
               affiliation:
                     name:University of California, San Francisco
                     address:
                        name:Department of Anatomy and Cardiovascular Research Institute, University of California, San Francisco, San Francisco, USA
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Early stages of chick somite development
      description:We report on the formation and early differentiation of the somites in the avian embryo. The somites are derived from the mesoderm which, in the body (excluding the head), is subdivided into four compartments: the axial, paraxial, intermediate and lateral plate mesoderm. Somites develop from the paraxial mesoderm and constitute the segmental pattern of the body. They are formed in pairs by epithelialization, first at the cranial end of the paraxial mesoderm, proceeding caudally, while new mesenchyme cells enter the paraxial mesoderm as a consequence of gastrulation. After their formation, which depends upon cell-cell and cell-matrix interactions, the somites impose segmental pattern upon peripheral nerves and vascular primordia. The newly formed somite consists of an epithelial ball of columnar cells enveloping mesenchymal cells within a central cavity, the somitocoel. Each somite is surrounded by extracellular matrix material connecting the somite with adjacent structures. The competence to form skeletal muscle is a unique property of the somites and becomes realized during compartmentalization, under control of signals emanating from surrounding tissues. Compartmentalization is accompanied by altered patterns of expression of Pax genes within the somite. These are believed to be involved in the specification of somite cell lineages. Somites are also regionally specified, giving rise to particular skeletal structures at different axial levels. This axial specification appears to be reflected in Hox gene expression. MyoD is first expressed in the dorsomedial quadrant of the still epithelial somite whose cells are not yet definitely committed. During early maturation, the ventral wall of the somite undergoes an epithelio-mesenchymal transition forming the sclerotome. The sclerotome later becomes subdivided into rostral and caudal halves which are separated laterally by von Ebner's fissure. The lateral part of the caudal half of the sclerotome mainly forms the ribs, neural arches and pedicles of vertebrae, whereas within the lateral part of the rostral half the spinal nerve develops. The medially migrating sclerotomal cells form the peri-notochordal sheath, and later give rise to the vertebral bodies and intervertebral discs. The somitocoel cells also contribute to the sclerotome. The dorsal half of the somite remains epithelial and is referred to as the dermomyotome because it gives rise to the dermis of the back and the skeletal musculature. The cells located within the lateral half of the dermomyotome are the precursors of the muscles of the hypaxial domain of the body, whereas those in the medial half are precursors of the epaxial (back) muscles. Single epithelial cells at the cranio-medial edge of the dermomyotome elongate in a caudal direction, beneath the dermomyotome, and become anchored at its caudal margin. These post-mitotic and muscle protein-expressing cells form the myotome. At limb levels, the precursors of hypaxial muscles undergo an epithelio-mesenchymal transition and migrate into the somatic mesoderm, where they replicate and later differentiate. These cells express the Pax-3 gene prior to, during and after this migration. All compartments of the somite contribute endothelial cells to the formation of vascular primordia. These cells, unlike all other cells of the somite, occasionally cross the midline of the developing embryo. We also suggest a method for staging somites according to their developmental age.
      datePublished:
      dateModified:
      pageStart:381
      pageEnd:396
      sameAs:https://doi.org/10.1007/BF00304424
      keywords:
         Avian embryo
         Paraxial mesoderm
         Somite differentiation
         Cell specification
         Somite staging
         Neurosciences
         Cell Biology
         Neurology
      image:
      isPartOf:
         name:Anatomy and Embryology
         issn:
            1432-0568
            0340-2061
         volumeNumber:191
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer-Verlag
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Bodo Christ
            affiliation:
                  name:University of Freiburg
                  address:
                     name:Institute of Anatomy, University of Freiburg, Freiburg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Charles P. Ordahl
            affiliation:
                  name:University of California, San Francisco
                  address:
                     name:Department of Anatomy and Cardiovascular Research Institute, University of California, San Francisco, San Francisco, USA
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Anatomy and Embryology
      issn:
         1432-0568
         0340-2061
      volumeNumber:191
Organization:
      name:Springer-Verlag
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Freiburg
      address:
         name:Institute of Anatomy, University of Freiburg, Freiburg, Germany
         type:PostalAddress
      name:University of California, San Francisco
      address:
         name:Department of Anatomy and Cardiovascular Research Institute, University of California, San Francisco, San Francisco, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Bodo Christ
      affiliation:
            name:University of Freiburg
            address:
               name:Institute of Anatomy, University of Freiburg, Freiburg, Germany
               type:PostalAddress
            type:Organization
      name:Charles P. Ordahl
      affiliation:
            name:University of California, San Francisco
            address:
               name:Department of Anatomy and Cardiovascular Research Institute, University of California, San Francisco, San Francisco, USA
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Institute of Anatomy, University of Freiburg, Freiburg, Germany
      name:Department of Anatomy and Cardiovascular Research Institute, University of California, San Francisco, San Francisco, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(168)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

5.57s.

LINK . SPRINGER . COM {}