
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney - PMC
Description:
During embryonic development, the kidney epithelium originates from cells that undergo a mesenchymal to epithelial transition (MET). The reverse process, epithelium to mesenchyme transition (EMT), has been implicated in epithelial tumor progression ...
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Keywords {🔍}
snail, cadherin, expression, figure, renal, kidney, hnfβ, fibrosis, cells, google, scholar, epithelial, doi, pubmed, promoter, activation, mouse, transgenic, human, mice, genes, development, transcription, kidneys, ecadherin, adult, emt, expressed, protein, tissue, transition, cell, collecting, ducts, pmc, nieto, mesenchyme, activity, transcripts, observed, gene, supplementary, duct, mesenchymal, article, fibrotic, levels, disease, nmumg, loss,
Topics {✒️}
tgf-β1/smad3 signaling protects [α-32p]dctp-labelled probes hepatocyte nuclear factor-1-beta hepatocyte nuclear factor-1β ligand-activated site-specific recombination wild-type hnf-1β promoter snail1-binding e-pal element liquid nitrogen-cooled isopentane pmc beta search zinc-finger transcription factors tamoxifen-inducible snail1-er construct ksp-cadherin gene promoter pcre-ert2 kindly provided human estrogen-receptor antibody tamoxifen/gram body weight hnf-1β promoter activities snail1-coding sequence fused showing hematoxylin/eosin staining free-floating slices compared hnf-1β expression mouse hnf-1β promoter snail1-er transfectant clones real-time rt–pcr pathological tgf-β signal areas expressing hnf-1β hnf-1β promoter sequences mouse mammary gland e-cadherin gene expression del barrio mg end-stage renal failure anti-human er antibody end-stage kidney failure antibodies anti-e-cadherin distal nonconserved e-box anti-smooth muscle actin snail1-er fusion protein transcription factor snail induced epithelial–mesenchymal transition quantitative rt–pcr analysis hnf-1β inhibits e-cadherin promoter sequences repressing e-cadherin expression e-cadherin promoter carrying human estrogen receptor consensus snail-binding sequences snail-expressing embryonic mesenchyme snail1-er-transfected cells organ-specific collagen expression highly conserved region snail1-inducible transgenic mice
Questions {❓}
- Burzynski SR (2005) Aging: gene silencing or gene activation?
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