
NCBI . NLM . NIH . GOV {
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Title[redir]:
Evidence that fibroblasts derive from epithelium during tissue fibrosis - PMC
Description:
Interstitial fibroblasts are principal effector cells of organ fibrosis in kidneys, lungs, and liver. While some view fibroblasts in adult tissues as nothing more than primitive mesenchymal cells surviving embryologic development, they differ from ...
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Keywords {🔍}
fibroblasts, doi, fsp, cells, marrow, pubmed, google, scholar, gfp, mice, kidney, lacz, bone, emt, kidneys, cell, uuo, tissue, figure, interstitial, normal, epithelium, green, fspgfp, tissues, tubular, γgtcre, number, epithelial, pmc, renal, transgenic, collagen, expression, usa, days, fibrosis, donor, transition, cortical, article, red, stained, hsp, fibroblast, promoter, free, epithelialmesenchymal, type, antibody,
Topics {✒️}
transforming growth factor-beta potential graft-versus-host disease cre-loxp-mediated gene targeting α-smooth muscle actin pmc beta search u-m41002-tritc filters tubular epithelial-myofibroblast transdifferentiation repressing e-cadherin expression cell-cell contact emblematic diethyl chlorophosphate–treated water anti-fsp1 antibody labeled metaplasia—switching cell types term epithelial-mesenchymal transition pmc copyright notice marrow-derived osteogenic precursors methods transgenic mice bone marrow–derived fibroblasts cd34-negative stem cells identified fibroblast-specific protein-1 wild-type donor marrow local epithelial-mesenchymal transition fibroblast-specific fsp1 promoter spontaneous emt-derived fsp1+ cis-acting elements emt-derived lacz+ fibroblasts paraffin-embedded kidney section cortical tubular epithelium gfp– wild-type mice results provide proof early embryologic development epithelial-mesenchymal transdifferentiation transitioning tubular epithelium nih grants dk-46282 cre recombinase splices transgenic mice results proliferating fibroblasts originated unfloxed tubular lacz+ muscle myosin ii anti-fsp1 antibody unilateral ureteral obstruction u-m41001-fitc specific protein markers mouse pro-alpha 1 license information pmcid roche molecular biochemicals olympus provis microscope epithelial-mesenchymal transitions epithelial-mesenchymal transformation endosteal lining cells texas red avidin
Questions {❓}
- See commentary "Renal interstitial fibrosis: Remembrance of things past?
- The evolving concept of a stem cell: entity or function?
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