
NCBI . NLM . NIH . GOV {
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Title[redir]:
Spatiotemporal Regulation of Epithelial-Mesenchymal Transition is Essential for Squamous Cell Carcinoma Metastasis - PMC
Description:
Epithelial-Mesenchymal Transition (EMT) is implicated in converting stationary epithelial tumor cells into motile mesenchymal cells during metastasis. However, the involvement of EMT in metastasis is still controversial due to the lack of a ...
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Keywords {🔍}
tumor, doi, cells, emt, twist, mice, metastasis, cell, cancer, pubmed, google, scholar, carcinoma, expression, distant, primary, figure, epithelial, metastases, doxycycline, pmc, human, mouse, model, ktwist, control, ecadherin, ctcs, tumors, metastatic, article, reversible, skin, group, lung, induction, free, proliferation, activation, promotes, breast, analysis, squamous, topical, mesenchymal, vivo, oral, circulating, transition, sites,
Topics {✒️}
serum-free keratinocyte media multi-stage chemical carcinogenesis rabbit anti-pan-cytokeratin antibody tetracycline-regulated transactivators tta experimental procedures generation tumor-bearing k5-twist1 mouse stat3-mediated signaling pathways tgfβ/smad signaling pathways pmc beta search doxycycline-treated k5-twist1 mice chicken anti-k5 antibody rabbit anti-e-cadherin tgf-beta1-mediated epithelial strong e-cadherin staining invadopodia-mediated ecm degradation rabbit anti-ki67 antibody epithelial markers e-cadherin absent e-cadherin expression repressing e-cadherin expression mouse anti-twist1 antibody relative e-cadherin levels epithelial-mesenchymal transition induced k5-twist1 mice receiving rabbit anti-pan-ck crossing tetop-twist1 mice k5-twist1 mice began k5-positive tumor cells circumvent twist1-induced emt e-cadherin gene expression paraffin-embedded tumor sections mouse anti-γ-catenin human cytokeratin-positive ctcs k5-twist1 mice presented site-specific integration twist1-positive tumor cells k5-twist1 mice prior confocal z-stack images supplementary materials included mouse anti-β-catenin references abel el transcription factor snail showed specific expression spontaneous tumor model squamous cell carcinoma moderately-differentiated epithelial morphology gapdh protein expression complete distinct steps 2mg/ml doxycycline water express e-cadherin skin carcinogenesis model
Questions {❓}
- Carcinoma invasion and metastasis: a role for epithelial-mesenchymal transition?
- Does tumour dormancy offer a therapeutic target?
- Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
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