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Title[redir]:
Breast tumor cell-specific knockout of Twist1 inhibits cancer cell plasticity, dissemination, and lung metastasis in mice - PMC
Description:
We found that Twist1 is coexpressed with multiple other epithelial–mesenchymal transition (EMT)-inducing transcription factors (TFs) in small subsets of primary and circulating breast tumor cells. Together, they program a partial EMT and a ...
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Keywords {🔍}
tumor, cells, twist, tumors, doi, cell, wtrcip, expression, mice, twisttkorcip, lung, metastasis, fig, cancer, appendix, ctcs, emt, pymt, pubmed, google, scholar, mouse, detected, snail, zeb, results, pmc, slug, article, ecadherin, vimentin, tfs, emtinducing, metastatic, primary, breast, markers, cre, staining, free, blood, partial, fsp, large, mammary, observed, number, mesenchymal, epithelial, metastases,
Topics {✒️}
basic helix–loop–helix domain twist/mi2/nurd protein complex late-stage twist1tko/rcip tumors late-stage wt/rcip tumors mmtv-tva/rcip mouse model 10-wk late-stage wt/rcip pymt-ha+/twist1+/vimentin+ tumor cells twist1−/k8−/k5+/p63+ basal late-stage advanced tumors twist1-induced epithelial-mesenchymal transition competent immune system pymt-ha+/twist1+ tumor cells early-stage tumor cells mmtv-tva×twist1f/+ heterozygous mice kras-induced pancreatic cancer rcip-induced primary tumors single virus-mediated coexpression org/lookup/suppl/doi rcip virus-induced initiation tva-expressing lecs infected stage twist1tko/rcip tumors texas grants rp120732-p5 disease-related biological functions advanced wt/rcip tumors tumor cell-specific pymt mmtv-tva/rcip system pmc beta search stage wt/rcip tumors rcip virus-infected lecs twist1+/vimentin+/fsp1− tumor cells tumor cell-specific ko large twist1tko/rcip tumors oncogene-induced mammary tumor large wt/rcip tumors twist1+/pymt+ cells express twist1tko/rcip mammary tumors mmtv-tva×twist1+/+/rcip twist1tko/rcip tumor cells twist1tko/rcip tumor sections 10-wk large wt/rcip immune-defective host mice wt/rcip tumor sections pymt-ha+ tumor cells laser-captured wt/rcip twist1+/k5+/p63+ basal twist1tko/rcip tumors showed aforementioned emt-inducing tfs moderate-level e-cadherin 10-wk twist1tko/rcip tumors e-cadherin-repressing factors
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