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We are analyzing https://www.nature.com/articles/s41580-020-0232-1.

Title:
The clearance of dead cells by efferocytosis | Nature Reviews Molecular Cell Biology
Description:
Multiple modes of cell death have been identified, each with a unique function and each induced in a setting-dependent manner. As billions of cells die during mammalian embryogenesis and daily in adult organisms, clearing dead cells and associated cellular debris is important in physiology. In this Review, we present an overview of the phagocytosis of dead and dying cells, a process known as efferocytosis. Efferocytosis is performed by macrophages and to a lesser extent by other ‘professional’ phagocytes (such as monocytes and dendritic cells) and ‘non-professional’ phagocytes, such as epithelial cells. Recent discoveries have shed light on this process and how it functions to maintain tissue homeostasis, tissue repair and organismal health. Here, we outline the mechanisms of efferocytosis, from the recognition of dying cells through to phagocytic engulfment and homeostatic resolution, and highlight the pathophysiological consequences that can arise when this process is abrogated. Development and homeostasis are dependent on rapid cell turnover, achieved by the programmed death and subsequent engulfment and breakdown of cells, a process known as efferocytosis. Defects in efferocytosis have been linked to a wide range of diseases; ongoing research therefore aims to better understand efferocytosis processes so as to uncover new therapeutic targets.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

  • Education
  • Science
  • Telecommunications

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


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$63,100 per month
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Keywords {🔍}

pubmed, article, google, scholar, cas, central, cell, cells, apoptotic, nature, biol, immunol, clearance, death, phagocytosis, inflammation, protein, macrophages, apoptosis, rev, efferocytosis, activation, nat, disease, macrophage, receptor, sci, signaling, immune, mol, membrane, tissue, response, inflammatory, molecular, role, recognition, signal, release, immunity, liver, dying, med, atherosclerosis, heckmann, green, engulfment, access, usa, cancer,

Topics {✒️}

permissions reprints research triangle park privacy policy nature portfolio journals author information authors scientific advisory board research hospital nature portfolio advertising social media intestinal epithelium-basic biology transforming growth factor-beta γ-aminobutyric acid receptor calcium-dependent phospholipid scrambling anti-hypertensive drug spironolactone cyclic gmp-amp synthase gamma-carboxyglutamic acid modification peroxisome proliferator-activated receptor mfg-e8 null mutations murine ischemia/reperfusion injury suppress pro-inflammatory eicosanoid coordinately induce anti-inflammatory bleomycin-induced lung injury gas6-axl-nlrp3 axis anti-nuclear antibodies complexed irg1/itaconate enhances efferocytosis �professional’ phagocytes professional’ phagocytes antiapoptotic mediator sphingosine-1-phosphate late-onset autoimmune syndrome anti-inflammatory mechanisms triggered end-directed vesicle transport mfg-e8-dependent clearance personal data embo long-term fellowship promotes anti-tumor immunity xk-related protein 8 elmo/dock180/rac module article boada-romero peer review efferocytosis emilio boada-romero apoptotic human t-cells phosphatidylserine-dependent homeostatic response permissions cell death based dominant pro-phagocytic signal data protection multiple human cancers springerlink instant access fatty acid oxidation

Questions {❓}

  • Macrophage reverse cholesterol transport: key to the regression of atherosclerosis?

Schema {🗺️}

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         description:Multiple modes of cell death have been identified, each with a unique function and each induced in a setting-dependent manner. As billions of cells die during mammalian embryogenesis and daily in adult organisms, clearing dead cells and associated cellular debris is important in physiology. In this Review, we present an overview of the phagocytosis of dead and dying cells, a process known as efferocytosis. Efferocytosis is performed by macrophages and to a lesser extent by other ‘professional’ phagocytes (such as monocytes and dendritic cells) and ‘non-professional’ phagocytes, such as epithelial cells. Recent discoveries have shed light on this process and how it functions to maintain tissue homeostasis, tissue repair and organismal health. Here, we outline the mechanisms of efferocytosis, from the recognition of dying cells through to phagocytic engulfment and homeostatic resolution, and highlight the pathophysiological consequences that can arise when this process is abrogated. Development and homeostasis are dependent on rapid cell turnover, achieved by the programmed death and subsequent engulfment and breakdown of cells, a process known as efferocytosis. Defects in efferocytosis have been linked to a wide range of diseases; ongoing research therefore aims to better understand efferocytosis processes so as to uncover new therapeutic targets.
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