We are analyzing https://link.springer.com/article/10.1007/s11357-010-9197-x.

Title:
Human muscle satellite cells show age-related differential expression of S100B protein and RAGE | GeroScience
Description:
During aging, skeletal muscles show reduced mass and functional capacity largely due to loss of the regenerative ability of satellite cells (SCs), the quiescent stem cells located beneath the basal lamina surrounding each myofiber. While both the external environment and intrinsic properties of SCs appear to contribute to the age-related SC deficiency, the latter ones have been poorly investigated especially in humans. In the present work, we analyzed several parameters of SCs derived from biopsies of vastus lateralis muscle from healthy non-trained young (28.7 ± 5.9 years; n = 10) and aged (77.3 ± 6.4 years; n = 11) people. Compared with young SCs, aged SCs showed impaired differentiation when cultured in differentiation medium, and exhibited the following: (1) reduced proliferation; (2) higher expression levels of S100B, a negative regulator of myoblast differentiation; (3) undetectable levels in growth medium of full-length RAGE (receptor for advanced glycation end products), a multiligand receptor of the immunoglobulin superfamily, the engagement of which enhances myoblast differentiation; and (4) lower expression levels of the transcription factors, MyoD and Pax7. Also, either overexpression of full-length RAGE or knockdown of S100B in aged SCs resulted in enhanced differentiation, while overexpression of either a non-transducing mutant of RAGE (RAGEΔcyto) or S100B in young SCs resulted in reduced differentiation compared with controls. Moreover, while aged SCs maintained the ability to respond to mitogenic factors (e.g., bFGF and S100B), they were no longer able to secrete these factors, unlike young SCs. These data support a role for intrinsic factors, besides the extracellular environment in the defective SC function in aged skeletal muscles.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Telecommunications

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,642,828 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We're unsure if the website is profiting.

While profit motivates many websites, others exist to inspire, entertain, or provide valuable resources. Websites have a variety of goals. And this might be one of them. Link.springer.com might be plotting its profit, but the way they're doing it isn't detectable yet.

Keywords {🔍}

article, google, scholar, pubmed, cas, muscle, cell, cells, satellite, aging, skeletal, donato, rage, differentiation, sorci, biol, stem, human, riuzzi, scs, young, physiol, mol, myogenic, content, expression, myoblast, receptor, factor, beccafico, growth, products, access, privacy, cookies, agerelated, protein, puglielli, fulle, reduced, functional, aged, proliferation, levels, factors, sci, exp, myoblasts, data, publish,

Topics {✒️}

month download article/chapter rosa mancinelli & stefania fulle age-related sc deficiency satellite-cell pool size human satellite cells muscle satellite cells article age aims igf1/pi3k/akt pathways cell-mediated gene therapy nf–κb-dependent inhibition human endothelial cells satellite cells fail stefania fulle full article pdf age-dependent imbalance myod-/- satellite cells stem cells aging skeletal muscle vastus lateralis muscle age-related calcium-regulated proteins s100a1 inhibits myoblast differentiation glycogenosis type ii age-dependent effects myogenic progenitor cells rhabdomyosarcoma cells results privacy choices/manage cookies enhances myoblast differentiation higher expression levels lower expression levels satellite cell numbers satellite cell content acute muscle injury aged skeletal muscles author information authors stem cell growth factor-1 signalling satellite cells tumour necrosis factor myoblast cell lines nf–κb signaling muscle differentiation nerve growth factor muscle healthy aging skeletal muscle reduced differentiation compared ph-regulated effects nf–kappab require van hinsbergh vw van loon lj

Questions {❓}

Zammit PS (2008) All muscle satellite cells are equal, but are some more equal than others?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Human muscle satellite cells show age-related differential expression of S100B protein and RAGE
         description:During aging, skeletal muscles show reduced mass and functional capacity largely due to loss of the regenerative ability of satellite cells (SCs), the quiescent stem cells located beneath the basal lamina surrounding each myofiber. While both the external environment and intrinsic properties of SCs appear to contribute to the age-related SC deficiency, the latter ones have been poorly investigated especially in humans. In the present work, we analyzed several parameters of SCs derived from biopsies of vastus lateralis muscle from healthy non-trained young (28.7 ± 5.9 years; n = 10) and aged (77.3 ± 6.4 years; n = 11) people. Compared with young SCs, aged SCs showed impaired differentiation when cultured in differentiation medium, and exhibited the following: (1) reduced proliferation; (2) higher expression levels of S100B, a negative regulator of myoblast differentiation; (3) undetectable levels in growth medium of full-length RAGE (receptor for advanced glycation end products), a multiligand receptor of the immunoglobulin superfamily, the engagement of which enhances myoblast differentiation; and (4) lower expression levels of the transcription factors, MyoD and Pax7. Also, either overexpression of full-length RAGE or knockdown of S100B in aged SCs resulted in enhanced differentiation, while overexpression of either a non-transducing mutant of RAGE (RAGEΔcyto) or S100B in young SCs resulted in reduced differentiation compared with controls. Moreover, while aged SCs maintained the ability to respond to mitogenic factors (e.g., bFGF and S100B), they were no longer able to secrete these factors, unlike young SCs. These data support a role for intrinsic factors, besides the extracellular environment in the defective SC function in aged skeletal muscles.
         datePublished:2010-12-08T00:00:00Z
         dateModified:2010-12-08T00:00:00Z
         pageStart:523
         pageEnd:541
         sameAs:https://doi.org/10.1007/s11357-010-9197-x
         keywords:
            Muscle satellite cells
            Aging
            Proliferation
            Differentiation
            S100B
            RAGE
            Cell Biology
            Geriatrics/Gerontology
            Molecular Medicine
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11357-010-9197-x/MediaObjects/11357_2010_9197_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11357-010-9197-x/MediaObjects/11357_2010_9197_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11357-010-9197-x/MediaObjects/11357_2010_9197_Fig3_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11357-010-9197-x/MediaObjects/11357_2010_9197_Fig4_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11357-010-9197-x/MediaObjects/11357_2010_9197_Fig5_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11357-010-9197-x/MediaObjects/11357_2010_9197_Fig6_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11357-010-9197-x/MediaObjects/11357_2010_9197_Fig7_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11357-010-9197-x/MediaObjects/11357_2010_9197_Fig8_HTML.gif
         isPartOf:
            name:AGE
            issn:
               1574-4647
               0161-9152
            volumeNumber:33
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer Netherlands
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Sara Beccafico
               affiliation:
                     name:University of Perugia
                     address:
                        name:Department of Experimental Medicine and Biochemical Sciences, IIM, University of Perugia, Perugia, Italy
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Francesca Riuzzi
               affiliation:
                     name:University of Perugia
                     address:
                        name:Department of Experimental Medicine and Biochemical Sciences, IIM, University of Perugia, Perugia, Italy
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Cristina Puglielli
               affiliation:
                     name:University G d’Annunzio
                     address:
                        name:Department of Neuroscience and Imaging, CeSI, IIM, University G d’Annunzio, Chieti-Pescara, Italy
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Rosa Mancinelli
               affiliation:
                     name:University G d’Annunzio
                     address:
                        name:Department of Neuroscience and Imaging, CeSI, IIM, University G d’Annunzio, Chieti-Pescara, Italy
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Stefania Fulle
               affiliation:
                     name:University G d’Annunzio
                     address:
                        name:Department of Neuroscience and Imaging, CeSI, IIM, University G d’Annunzio, Chieti-Pescara, Italy
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Guglielmo Sorci
               affiliation:
                     name:University of Perugia
                     address:
                        name:Department of Experimental Medicine and Biochemical Sciences, IIM, University of Perugia, Perugia, Italy
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Rosario Donato
               affiliation:
                     name:University of Perugia
                     address:
                        name:Department of Experimental Medicine and Biochemical Sciences, IIM, University of Perugia, Perugia, Italy
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Human muscle satellite cells show age-related differential expression of S100B protein and RAGE
      description:During aging, skeletal muscles show reduced mass and functional capacity largely due to loss of the regenerative ability of satellite cells (SCs), the quiescent stem cells located beneath the basal lamina surrounding each myofiber. While both the external environment and intrinsic properties of SCs appear to contribute to the age-related SC deficiency, the latter ones have been poorly investigated especially in humans. In the present work, we analyzed several parameters of SCs derived from biopsies of vastus lateralis muscle from healthy non-trained young (28.7 ± 5.9 years; n = 10) and aged (77.3 ± 6.4 years; n = 11) people. Compared with young SCs, aged SCs showed impaired differentiation when cultured in differentiation medium, and exhibited the following: (1) reduced proliferation; (2) higher expression levels of S100B, a negative regulator of myoblast differentiation; (3) undetectable levels in growth medium of full-length RAGE (receptor for advanced glycation end products), a multiligand receptor of the immunoglobulin superfamily, the engagement of which enhances myoblast differentiation; and (4) lower expression levels of the transcription factors, MyoD and Pax7. Also, either overexpression of full-length RAGE or knockdown of S100B in aged SCs resulted in enhanced differentiation, while overexpression of either a non-transducing mutant of RAGE (RAGEΔcyto) or S100B in young SCs resulted in reduced differentiation compared with controls. Moreover, while aged SCs maintained the ability to respond to mitogenic factors (e.g., bFGF and S100B), they were no longer able to secrete these factors, unlike young SCs. These data support a role for intrinsic factors, besides the extracellular environment in the defective SC function in aged skeletal muscles.
      datePublished:2010-12-08T00:00:00Z
      dateModified:2010-12-08T00:00:00Z
      pageStart:523
      pageEnd:541
      sameAs:https://doi.org/10.1007/s11357-010-9197-x
      keywords:
         Muscle satellite cells
         Aging
         Proliferation
         Differentiation
         S100B
         RAGE
         Cell Biology
         Geriatrics/Gerontology
         Molecular Medicine
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11357-010-9197-x/MediaObjects/11357_2010_9197_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11357-010-9197-x/MediaObjects/11357_2010_9197_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11357-010-9197-x/MediaObjects/11357_2010_9197_Fig3_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11357-010-9197-x/MediaObjects/11357_2010_9197_Fig4_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11357-010-9197-x/MediaObjects/11357_2010_9197_Fig5_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11357-010-9197-x/MediaObjects/11357_2010_9197_Fig6_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11357-010-9197-x/MediaObjects/11357_2010_9197_Fig7_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11357-010-9197-x/MediaObjects/11357_2010_9197_Fig8_HTML.gif
      isPartOf:
         name:AGE
         issn:
            1574-4647
            0161-9152
         volumeNumber:33
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Netherlands
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Sara Beccafico
            affiliation:
                  name:University of Perugia
                  address:
                     name:Department of Experimental Medicine and Biochemical Sciences, IIM, University of Perugia, Perugia, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Francesca Riuzzi
            affiliation:
                  name:University of Perugia
                  address:
                     name:Department of Experimental Medicine and Biochemical Sciences, IIM, University of Perugia, Perugia, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Cristina Puglielli
            affiliation:
                  name:University G d’Annunzio
                  address:
                     name:Department of Neuroscience and Imaging, CeSI, IIM, University G d’Annunzio, Chieti-Pescara, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Rosa Mancinelli
            affiliation:
                  name:University G d’Annunzio
                  address:
                     name:Department of Neuroscience and Imaging, CeSI, IIM, University G d’Annunzio, Chieti-Pescara, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Stefania Fulle
            affiliation:
                  name:University G d’Annunzio
                  address:
                     name:Department of Neuroscience and Imaging, CeSI, IIM, University G d’Annunzio, Chieti-Pescara, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Guglielmo Sorci
            affiliation:
                  name:University of Perugia
                  address:
                     name:Department of Experimental Medicine and Biochemical Sciences, IIM, University of Perugia, Perugia, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Rosario Donato
            affiliation:
                  name:University of Perugia
                  address:
                     name:Department of Experimental Medicine and Biochemical Sciences, IIM, University of Perugia, Perugia, Italy
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:AGE
      issn:
         1574-4647
         0161-9152
      volumeNumber:33
Organization:
      name:Springer Netherlands
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Perugia
      address:
         name:Department of Experimental Medicine and Biochemical Sciences, IIM, University of Perugia, Perugia, Italy
         type:PostalAddress
      name:University of Perugia
      address:
         name:Department of Experimental Medicine and Biochemical Sciences, IIM, University of Perugia, Perugia, Italy
         type:PostalAddress
      name:University G d’Annunzio
      address:
         name:Department of Neuroscience and Imaging, CeSI, IIM, University G d’Annunzio, Chieti-Pescara, Italy
         type:PostalAddress
      name:University G d’Annunzio
      address:
         name:Department of Neuroscience and Imaging, CeSI, IIM, University G d’Annunzio, Chieti-Pescara, Italy
         type:PostalAddress
      name:University G d’Annunzio
      address:
         name:Department of Neuroscience and Imaging, CeSI, IIM, University G d’Annunzio, Chieti-Pescara, Italy
         type:PostalAddress
      name:University of Perugia
      address:
         name:Department of Experimental Medicine and Biochemical Sciences, IIM, University of Perugia, Perugia, Italy
         type:PostalAddress
      name:University of Perugia
      address:
         name:Department of Experimental Medicine and Biochemical Sciences, IIM, University of Perugia, Perugia, Italy
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Sara Beccafico
      affiliation:
            name:University of Perugia
            address:
               name:Department of Experimental Medicine and Biochemical Sciences, IIM, University of Perugia, Perugia, Italy
               type:PostalAddress
            type:Organization
      name:Francesca Riuzzi
      affiliation:
            name:University of Perugia
            address:
               name:Department of Experimental Medicine and Biochemical Sciences, IIM, University of Perugia, Perugia, Italy
               type:PostalAddress
            type:Organization
      name:Cristina Puglielli
      affiliation:
            name:University G d’Annunzio
            address:
               name:Department of Neuroscience and Imaging, CeSI, IIM, University G d’Annunzio, Chieti-Pescara, Italy
               type:PostalAddress
            type:Organization
      name:Rosa Mancinelli
      affiliation:
            name:University G d’Annunzio
            address:
               name:Department of Neuroscience and Imaging, CeSI, IIM, University G d’Annunzio, Chieti-Pescara, Italy
               type:PostalAddress
            type:Organization
      name:Stefania Fulle
      affiliation:
            name:University G d’Annunzio
            address:
               name:Department of Neuroscience and Imaging, CeSI, IIM, University G d’Annunzio, Chieti-Pescara, Italy
               type:PostalAddress
            type:Organization
      name:Guglielmo Sorci
      affiliation:
            name:University of Perugia
            address:
               name:Department of Experimental Medicine and Biochemical Sciences, IIM, University of Perugia, Perugia, Italy
               type:PostalAddress
            type:Organization
      name:Rosario Donato
      affiliation:
            name:University of Perugia
            address:
               name:Department of Experimental Medicine and Biochemical Sciences, IIM, University of Perugia, Perugia, Italy
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Experimental Medicine and Biochemical Sciences, IIM, University of Perugia, Perugia, Italy
      name:Department of Experimental Medicine and Biochemical Sciences, IIM, University of Perugia, Perugia, Italy
      name:Department of Neuroscience and Imaging, CeSI, IIM, University G d’Annunzio, Chieti-Pescara, Italy
      name:Department of Neuroscience and Imaging, CeSI, IIM, University G d’Annunzio, Chieti-Pescara, Italy
      name:Department of Neuroscience and Imaging, CeSI, IIM, University G d’Annunzio, Chieti-Pescara, Italy
      name:Department of Experimental Medicine and Biochemical Sciences, IIM, University of Perugia, Perugia, Italy
      name:Department of Experimental Medicine and Biochemical Sciences, IIM, University of Perugia, Perugia, Italy
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(190)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.32s.

LINK . SPRINGER . COM {}