We are analyzing https://link.springer.com/article/10.1007/s10495-010-0478-8.

Title:
Inefficient clearance of dying cells in patients with SLE: anti-dsDNA autoantibodies, MFG-E8, HMGB-1 and other players | Apoptosis
Description:
Systemic lupus erythematosus (SLE) is a complex disease resulting from inflammatory responses of the immune system against several autoantigens. Inflammation is conditioned by the continuous presence of autoantibodies and leaked autoantigens, e.g. from not properly cleared dying and dead cells. Various soluble molecules and biophysical properties of the surface of apoptotic cells play significant roles in the appropriate recognition and further processing of dying and dead cells. We exemplarily discuss how Milk fat globule epidermal growth factor 8 (MFG-E8), biophysical membrane alterations, High mobility group box 1 (HMGB1), C-reactive protein (CRP), and anti-nuclear autoantibodies may contribute to the etiopathogenesis of the disease. Up to date knowledge about these key elements may provide new insights that lead to the development of new treatment strategies of the disease.
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

google, scholar, pubmed, protein, lupus, creactive, cells, immunol, systemic, erythematosus, hmgb, apoptotic, rheum, human, arthritis, herrmann, cell, kalden, voll, disease, med, antibodies, group, exp, expression, dna, bianchi, immune, binding, mice, article, patients, autoantibodies, mfge, high, proteins, clin, apoptosis, mobility, biochem, hmg, nuclear, wang, gaipl, nagata, activity, van, university, clearance, sle,

Topics {✒️}

anti-double-stranded dna antibodies anti-double-stranded dna autoantibodies milk-fat globule protein c-reactive protein mediates month download article/chapter modified c-reactive protein experimentally uv-induced lesions human c-reactive protein c-reactive protein reacts targeting c-reactive protein monomeric c-reactive protein neutrophil-endothelial cell adhesion transforming growth factor-beta c-reactive protein levels multiply o-glycosylated domain anti-chromatin autoantibody production c-reactive protein expression nk/idc interaction results /ebp-beta complex formation anti-nucleosome antibodies complexed anti-ds dna antibodies interferon-alpha production c-reactive protein binds high mobility group serum autoantibody profiles biophysical membrane alterations vesicle-mediated secretory pathway plasma membrane constituents tlr9-mediated inflammatory responses mfg-e8-deficient mice epidermal growth factor necrotic cell-derived chromatin systemic autoimmune diseases nucleic acid released c-reactive protein chromosomal protein hmg1 peripheral membrane protein major milk protein du clos tw macrophage cytokine production apoptotic cell death weaning-induced expression developmental endothelial locus-1 phosphatidylserine-binding activity systemic rheumatic diseases cytomix-induced hyperpermeability hmgb1 chromosomal protein induces autoantibody production privacy choices/manage cookies disrupt cell growth

Questions {❓}

Frisoni L, McPhie L, Colonna L, Sriram U, Monestier M, Gallucci S, Caricchio R (2005) Nuclear autoantigen translocation and autoantibody opsonization lead to increased dendritic cell phagocytosis and presentation of nuclear antigens: a novel pathogenic pathway for autoimmunity?
Isenberg DA, Manson JJ, Ehrenstein MR, Rahman A (2007) Fifty years of anti-ds DNA antibodies: are we approaching journey’s end?

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