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nature portfolio journals nature portfolio privacy policy high-sensitivity c-reactive protein peroxisome proliferator-activated receptor-δ advertising social media caspase-11-gasdermin d-mediated pyroptosis reprints streptozotocin-induced hyperglycemia mediated hypoxia-inducible factor-1α β-amyloid precursor protein apolipoprotein e-null mice reduce nf-κb activation nature+ nature 407 nature 536 nature 464 nature 575 nature secrete matrix-degrading enzymes pfkfb3-targeted pet tracer apolipoprotein e-deficient mice apolipoprotein e-deficient mice simvastatin-dependent plaque stabilization thp-1-derived foam cells pore-forming protein gasdermin p50/p50-mediated suppression publishing agreement annexin-derived peptide ac authors researched data targeted anti-cytokine therapies rip3-mediated macrophage necrosis placebo-controlled study author information authors drug-induced macrophage autophagy apoe3-leiden transgenic mice successful interleukin-1β inhibition dna-binding cytokine hmgb1 potential ferroptosis-related biomarkers permissions springerlink instant access placebo-controlled clinical trial regulates macrophage retention peer review personal data promotes macrophage necroptosis ripk1 kinase inhibition targeting macrophage necroptosis specific cellular target

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