
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Colchicine Acutely Suppresses Local Cardiac Production of Inflammatory Cytokines in Patients With an Acute Coronary Syndrome - PMC
Description:
Interleukin (IL)-1Ξ², IL-18, and downstream IL-6 are key inflammatory cytokines in the pathogenesis of coronary artery disease. Colchicine is believed to block the NLRP3 inflammasome, a cytosolic complex responsible for the production of IL-1Ξ² and ...
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Keywords {π}
doi, patients, colchicine, coronary, acs, ilΞ², pubmed, google, scholar, cad, stable, acute, disease, study, production, interleukin, cytokines, venous, levels, treatment, inflammation, events, inflammatory, inflammasome, transcoronary, cardiovascular, group, figure, cardiac, significant, groups, pgml, gradient, pmc, artery, arterial, increased, clinical, heart, results, significantly, plaque, local, cytokine, controls, concentrations, syndrome, blood, protein, versus,
Topics {βοΈ}
whitlow pl acc/aha/scai angiotensin-converting enzyme inhibitors tumor necrosis factor-Ξ± nucleotide-binding oligomerization domain microtubule-driven spatial arrangement pmc beta search grace uk-belgian study pmc copyright notice inflammasome-specific cytokines il-1Ξ² decreased c-reactive protein mrc-ila heart study recent-onset chest pain potent anti-inflammatory drug b-cell activation atherosclerotic plaque development short-term colchicine administration inflammasome-specific inflammatory cytokines short-term colchicine treatment reduced atherosclerotic lesions circulating cells modulates increased plaque vulnerability dose-comparison colchicine study long-term colchicine treatment increased local production healed myocardial infarction local cardiac production acute myocardial infarction human atherosclerotic plaques high-sensitivity crp levels local coronary production american heart association common post-acs publisher site pdf increased transcoronary production coronary artery disease acs colchicine-naΓ―ve patients license information pmcid exerts pro-inflammatory st segment positive cardiac enzymes acute coronary syndromes acute coronary syndromes influence inflammasome activation apoe-deficient mice transcoronary concentration gradients anti-inflammatory therapies long-term exposure mitochondria promotes activation pro-inflammatory cytokines c-reactive protein
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