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Title[redir]:
Cleavage of the death domain kinase RIP by Caspase-8 prompts TNF-induced apoptosis - PMC
Description:
Although the molecular mechanisms of TNF signaling have been largely elucidated, the principle that regulates the balance of life and death is still unknown. We report here that the death domain kinase RIP, a key component of the TNF signaling ...
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Keywords {🔍}
rip, cells, doi, cleavage, death, apoptosis, tnf, cell, pubmed, google, scholar, nfκb, caspase, tnfinduced, activation, fig, shown, protein, lane, fadd, proteins, figure, ripc, hela, domain, expression, receptor, science, extract, cleaved, tradd, treated, lanes, detected, western, apoptotic, signaling, treatment, wildtype, traf, chx, experiments, transfected, results, antibody, interaction, tnfr, ngml, μgml, ripdk,
Topics {✒️}
activating mekk/jnkk/jnk pathway activation-induced t-cell proliferation nf-κb regulates fas/apo-1/cd95 tnf-induced nf-κb signal tumor necrosis factor-alpha tnf-induced nf-κb activation c-jun amino-terminal kinase nf-κb-mediated cell survival uncleaved full-length rip mediate nf-κb activation constitutively activating nf-κb continue activating nf-κb ligand-induced death signals pmc beta search amino-terminal myc-tagged cancer therapy-induced apoptosis full-length rip protein functional nf-κb activation iκb-nf-κb structures cytokine-responsive iκb kinase tnf-alpha-induced apoptosis interleukin-1β converting enzyme nf-κb protects cells jr nf-κb antiapoptosis robustly activate nf-κb initiate tnf-induced apoptosis transcription factor nf-κb block tnf-induced death bcl-xl functions downstream nf-κb reporter plasmid tnf/ngf receptor superfamily multiple cysteine-rich domains tumor necrosis factor death receptor-mediated apoptosis map3k-related kinase involved anti-fas-treated jurkat cells mice lacking fadd/mort1 wild-type jurkat cells wild-type versus rip wild-type rip interfered myc-tagged rip proteins noncytotoxic traf2-dependent pathway 35s-labeled rip protein tnf-induced cell death tradd-fadd interactions define tnfr2-traf signaling complex nf-κb inducing ability anti-rip antibody recognized 35s-labeled rip proteins rip-deficient jurkat cells
Questions {❓}
- Is RIP cleavage a general mechanism for death receptor-mediated apoptosis?
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