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The IL-23–IL-17 immune axis: from mechanisms to therapeutic testing | Nature Reviews Immunology
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T helper 17 (TH17) cells promote protective immune responses against infection, particularly at barrier sites, but they can also have pathogenic roles in inflammatory diseases. In this Review, the authors describe the factors that control the development and maintenance of TH17 cells, and discuss their diverse functions in both health and disease. Following the discovery of T helper 17 (TH17) cells, the past decade has witnessed a major revision of the TH subset paradigm and substantial progress has been made in deciphering the molecular mechanisms of T cell lineage commitment and function. In this Review, we focus on the recent advances that have been made regarding the transcriptional control of TH17 cell plasticity and stability, as well as the effector functions of TH17 cells, and we highlight the mechanisms of IL-17 signalling in mesenchymal and barrier epithelial tissues. We also discuss the emerging clinical data showing that IL-17-specific and IL-23-specific antibody treatments are remarkably effective for treating many immune-mediated inflammatory diseases.
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ubiquitin-editing enzyme a20 late-breaking research symposium permissions reprints privacy policy author information authors nature portfolio received research grants advertising il-17-induced nf-κb activation mitogen-activated protein kinases interferon-γ-expressing th17 cells social media il-17ra-specific antibody therapy transforming growth factor-β il-17-induced act1-mediated cxcl1 il-17r-mediated signalling axis related links author correspondence ubiquitin-specific protease usp25 double-blind placebo-controlled trial selective nf-κb activation il-23-specific antibody treatments ccaat/enhancer-binding proteins erk1/2-dependent nf-κb anti-interleukin-17-receptor antibody siderophore-mediated iron acquisition pre-existent enhancer landscape tumor necrosis factor-α genome-wide association study anti-il-17 mabs herald immune-mediated inflammatory diseases single-stranded rna molecules splicing-regulatory factor sf2 scfβ-trcp-mediated degradation conserved sef/il-17r card15/nod2 mutational analysis inherited il-12p40 deficiency tnf-α-induced genes mediating il-25-induced activities glossary crohn' aryl hydrocarbon receptor key competitive advantage dual-specificity phosphatases 22-deficient cell-dependent iga responses il-23–il-17 immune axis il-23-induced il-17 production ankylosing spondylitis identifies springerlink instant access il-17f-induced effects il-17r signalling pathway
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T helper 17 (TH17) cells promote protective immune responses against infection, particularly at barrier sites, but they can also have pathogenic roles in inflammatory diseases. In this Review, the authors describe the factors that control the development and maintenance of TH17 cells, and discuss their diverse functions in both health and disease. Following the discovery of T helper 17 (TH17) cells, the past decade has witnessed a major revision of the TH subset paradigm and substantial progress has been made in deciphering the molecular mechanisms of T cell lineage commitment and function. In this Review, we focus on the recent advances that have been made regarding the transcriptional control of TH17 cell plasticity and stability, as well as the effector functions of TH17 cells, and we highlight the mechanisms of IL-17 signalling in mesenchymal and barrier epithelial tissues. We also discuss the emerging clinical data showing that IL-17-specific and IL-23-specific antibody treatments are remarkably effective for treating many immune-mediated inflammatory diseases.
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T helper 17 (TH17) cells promote protective immune responses against infection, particularly at barrier sites, but they can also have pathogenic roles in inflammatory diseases. In this Review, the authors describe the factors that control the development and maintenance of TH17 cells, and discuss their diverse functions in both health and disease. Following the discovery of T helper 17 (TH17) cells, the past decade has witnessed a major revision of the TH subset paradigm and substantial progress has been made in deciphering the molecular mechanisms of T cell lineage commitment and function. In this Review, we focus on the recent advances that have been made regarding the transcriptional control of TH17 cell plasticity and stability, as well as the effector functions of TH17 cells, and we highlight the mechanisms of IL-17 signalling in mesenchymal and barrier epithelial tissues. We also discuss the emerging clinical data showing that IL-17-specific and IL-23-specific antibody treatments are remarkably effective for treating many immune-mediated inflammatory diseases.
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