Here's how NATURE.COM makes money* and how much!

*Please read our disclaimer before using our estimates.
Loading...

NATURE . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Nature.com Make Money
  6. How Much Does Nature.com Make
  7. Keywords
  8. Topics
  9. Questions
  10. Schema
  11. Social Networks
  12. External Links
  13. Analytics And Tracking
  14. Libraries
  15. Hosting Providers
  16. CDN Services

We are analyzing https://www.nature.com/articles/nri3707.

Title:
The IL-23–IL-17 immune axis: from mechanisms to therapeutic testing | Nature Reviews Immunology
Description:
T helper 17 (TH17) cells promote protective immune responses against infection, particularly at barrier sites, but they can also have pathogenic roles in inflammatory diseases. In this Review, the authors describe the factors that control the development and maintenance of TH17 cells, and discuss their diverse functions in both health and disease. Following the discovery of T helper 17 (TH17) cells, the past decade has witnessed a major revision of the TH subset paradigm and substantial progress has been made in deciphering the molecular mechanisms of T cell lineage commitment and function. In this Review, we focus on the recent advances that have been made regarding the transcriptional control of TH17 cell plasticity and stability, as well as the effector functions of TH17 cells, and we highlight the mechanisms of IL-17 signalling in mesenchymal and barrier epithelial tissues. We also discuss the emerging clinical data showing that IL-17-specific and IL-23-specific antibody treatments are remarkably effective for treating many immune-mediated inflammatory diseases.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

  • Education
  • Science
  • Health & Fitness

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌆 Monumental Traffic: 20M - 50M visitors per month


Based on our best estimate, this website will receive around 41,362,249 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}


Display Ads {🎯}


The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.

Ads are managed by yourbow.com. Particular relationships are as follows:

Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.com

Reseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.com

How Much Does Nature.com Make? {💰}


Display Ads {🎯}

$521,200 per month
Our analysis indicates Nature.com generates between $347,485 and $955,583 monthly online from display ads.

Keywords {🔍}

pubmed, article, google, scholar, cas, nature, central, cells, immunol, cell, interleukin, immunity, autoimmune, inflammation, inflammatory, receptor, med, disease, helper, factor, differentiation, psoriasis, signaling, rev, transcription, cytokine, human, lineage, signal, exp, chronic, signalling, study, function, rorγt, act, stat, candidiasis, gaffen, regulatory, content, mechanisms, transforming, growth, protein, regulation, access, biol, essential, information,

Topics {✒️}

ubiquitin-editing enzyme a20 late-breaking research symposium permissions reprints privacy policy author information authors nature portfolio received research grants advertising il-17-induced nf-κb activation mitogen-activated protein kinases interferon-γ-expressing th17 cells social media il-17ra-specific antibody therapy transforming growth factor-β il-17-induced act1-mediated cxcl1 il-17r-mediated signalling axis related links author correspondence ubiquitin-specific protease usp25 double-blind placebo-controlled trial selective nf-κb activation il-23-specific antibody treatments ccaat/enhancer-binding proteins erk1/2-dependent nf-κb anti-interleukin-17-receptor antibody siderophore-mediated iron acquisition pre-existent enhancer landscape tumor necrosis factor-α genome-wide association study anti-il-17 mabs herald immune-mediated inflammatory diseases single-stranded rna molecules splicing-regulatory factor sf2 scfβ-trcp-mediated degradation conserved sef/il-17r card15/nod2 mutational analysis inherited il-12p40 deficiency tnf-α-induced genes mediating il-25-induced activities glossary crohn' aryl hydrocarbon receptor key competitive advantage dual-specificity phosphatases 22-deficient cell-dependent iga responses il-23–il-17 immune axis il-23-induced il-17 production ankylosing spondylitis identifies springerlink instant access il-17f-induced effects il-17r signalling pathway

Questions {❓}

  • Master regulators or lineage-specifying?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:The IL-23–IL-17 immune axis: from mechanisms to therapeutic testing
         description: T helper 17 (TH17) cells promote protective immune responses against infection, particularly at barrier sites, but they can also have pathogenic roles in inflammatory diseases. In this Review, the authors describe the factors that control the development and maintenance of TH17 cells, and discuss their diverse functions in both health and disease. Following the discovery of T helper 17 (TH17) cells, the past decade has witnessed a major revision of the TH subset paradigm and substantial progress has been made in deciphering the molecular mechanisms of T cell lineage commitment and function. In this Review, we focus on the recent advances that have been made regarding the transcriptional control of TH17 cell plasticity and stability, as well as the effector functions of TH17 cells, and we highlight the mechanisms of IL-17 signalling in mesenchymal and barrier epithelial tissues. We also discuss the emerging clinical data showing that IL-17-specific and IL-23-specific antibody treatments are remarkably effective for treating many immune-mediated inflammatory diseases.
         datePublished:2014-08-22T00:00:00Z
         dateModified:2014-08-22T00:00:00Z
         pageStart:585
         pageEnd:600
         sameAs:https://doi.org/10.1038/nri3707
         keywords:
            Inflammatory diseases
            Interleukins
            T-helper 17 cells
            Biomedicine
            general
            Immunology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnri3707/MediaObjects/41577_2014_Article_BFnri3707_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnri3707/MediaObjects/41577_2014_Article_BFnri3707_Figa_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnri3707/MediaObjects/41577_2014_Article_BFnri3707_Fig2_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnri3707/MediaObjects/41577_2014_Article_BFnri3707_Fig3_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnri3707/MediaObjects/41577_2014_Article_BFnri3707_Fig4_HTML.jpg
         isPartOf:
            name:Nature Reviews Immunology
            issn:
               1474-1741
               1474-1733
            volumeNumber:14
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group UK
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Sarah L. Gaffen
               affiliation:
                     name:Division of Rheumatology and Clinical Immunology
                     address:
                        name:Division of Rheumatology and Clinical Immunology, Pittsburgh, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Renu Jain
               affiliation:
                     name:Merck Research Laboratories, Palo Alto
                     address:
                        name:Merck Research Laboratories, Palo Alto, Palo Alto, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Abhishek V. Garg
               affiliation:
                     name:Division of Rheumatology and Clinical Immunology
                     address:
                        name:Division of Rheumatology and Clinical Immunology, Pittsburgh, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Daniel J. Cua
               affiliation:
                     name:Merck Research Laboratories, Palo Alto
                     address:
                        name:Merck Research Laboratories, Palo Alto, Palo Alto, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:The IL-23–IL-17 immune axis: from mechanisms to therapeutic testing
      description: T helper 17 (TH17) cells promote protective immune responses against infection, particularly at barrier sites, but they can also have pathogenic roles in inflammatory diseases. In this Review, the authors describe the factors that control the development and maintenance of TH17 cells, and discuss their diverse functions in both health and disease. Following the discovery of T helper 17 (TH17) cells, the past decade has witnessed a major revision of the TH subset paradigm and substantial progress has been made in deciphering the molecular mechanisms of T cell lineage commitment and function. In this Review, we focus on the recent advances that have been made regarding the transcriptional control of TH17 cell plasticity and stability, as well as the effector functions of TH17 cells, and we highlight the mechanisms of IL-17 signalling in mesenchymal and barrier epithelial tissues. We also discuss the emerging clinical data showing that IL-17-specific and IL-23-specific antibody treatments are remarkably effective for treating many immune-mediated inflammatory diseases.
      datePublished:2014-08-22T00:00:00Z
      dateModified:2014-08-22T00:00:00Z
      pageStart:585
      pageEnd:600
      sameAs:https://doi.org/10.1038/nri3707
      keywords:
         Inflammatory diseases
         Interleukins
         T-helper 17 cells
         Biomedicine
         general
         Immunology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnri3707/MediaObjects/41577_2014_Article_BFnri3707_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnri3707/MediaObjects/41577_2014_Article_BFnri3707_Figa_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnri3707/MediaObjects/41577_2014_Article_BFnri3707_Fig2_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnri3707/MediaObjects/41577_2014_Article_BFnri3707_Fig3_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnri3707/MediaObjects/41577_2014_Article_BFnri3707_Fig4_HTML.jpg
      isPartOf:
         name:Nature Reviews Immunology
         issn:
            1474-1741
            1474-1733
         volumeNumber:14
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Sarah L. Gaffen
            affiliation:
                  name:Division of Rheumatology and Clinical Immunology
                  address:
                     name:Division of Rheumatology and Clinical Immunology, Pittsburgh, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Renu Jain
            affiliation:
                  name:Merck Research Laboratories, Palo Alto
                  address:
                     name:Merck Research Laboratories, Palo Alto, Palo Alto, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Abhishek V. Garg
            affiliation:
                  name:Division of Rheumatology and Clinical Immunology
                  address:
                     name:Division of Rheumatology and Clinical Immunology, Pittsburgh, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Daniel J. Cua
            affiliation:
                  name:Merck Research Laboratories, Palo Alto
                  address:
                     name:Merck Research Laboratories, Palo Alto, Palo Alto, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Nature Reviews Immunology
      issn:
         1474-1741
         1474-1733
      volumeNumber:14
Organization:
      name:Nature Publishing Group UK
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Division of Rheumatology and Clinical Immunology
      address:
         name:Division of Rheumatology and Clinical Immunology, Pittsburgh, USA
         type:PostalAddress
      name:Merck Research Laboratories, Palo Alto
      address:
         name:Merck Research Laboratories, Palo Alto, Palo Alto, USA
         type:PostalAddress
      name:Division of Rheumatology and Clinical Immunology
      address:
         name:Division of Rheumatology and Clinical Immunology, Pittsburgh, USA
         type:PostalAddress
      name:Merck Research Laboratories, Palo Alto
      address:
         name:Merck Research Laboratories, Palo Alto, Palo Alto, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Sarah L. Gaffen
      affiliation:
            name:Division of Rheumatology and Clinical Immunology
            address:
               name:Division of Rheumatology and Clinical Immunology, Pittsburgh, USA
               type:PostalAddress
            type:Organization
      name:Renu Jain
      affiliation:
            name:Merck Research Laboratories, Palo Alto
            address:
               name:Merck Research Laboratories, Palo Alto, Palo Alto, USA
               type:PostalAddress
            type:Organization
      name:Abhishek V. Garg
      affiliation:
            name:Division of Rheumatology and Clinical Immunology
            address:
               name:Division of Rheumatology and Clinical Immunology, Pittsburgh, USA
               type:PostalAddress
            type:Organization
      name:Daniel J. Cua
      affiliation:
            name:Merck Research Laboratories, Palo Alto
            address:
               name:Merck Research Laboratories, Palo Alto, Palo Alto, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Division of Rheumatology and Clinical Immunology, Pittsburgh, USA
      name:Merck Research Laboratories, Palo Alto, Palo Alto, USA
      name:Division of Rheumatology and Clinical Immunology, Pittsburgh, USA
      name:Merck Research Laboratories, Palo Alto, Palo Alto, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(597)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Prism.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mxa-002c5801.gslb.pphosted.com
  • mxb-002c5801.gslb.pphosted.com

Name Servers:

  • pdns1.ultradns.net
  • pdns2.ultradns.net
  • pdns3.ultradns.org
  • pdns4.ultradns.org
  • pdns5.ultradns.info
  • pdns6.ultradns.co.uk

CDN Services {📦}

  • Crossref

4.75s.