
NCBI . NLM . NIH . GOV {
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Title[redir]:
Stabilization of the Transcription Factor Foxp3 by the Deubiquitinase USP7 Increases Treg-Cell-Suppressive Capacity - PMC
Description:
Stable Foxp3 expression is required for the development of functional regulatory T (Treg) cells. Here, we demonstrate that the expression of the transcription factor Foxp3 can be regulated through the polyubiquitination of multiple lysine residues, ...
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Keywords {π}
foxp, cells, treg, usp, expression, doi, protein, cell, figure, pubmed, google, scholar, mice, data, human, dubi, ubiquitination, analyzed, pmc, lysine, treatment, regulatory, residues, polyubiquitination, degradation, van, knockdown, function, article, increased, ubiquitin, suppression, reduced, control, ubiquitinated, decreased, tregcellmediated, free, analysis, amounts, figures, performed, activity, loosdregt, specific, dubs, previously, determine, hek, hafoxp,
Topics {βοΈ}
flag-ubiquitin-k7xr-foxp3 fusion constructs ubi-k7xr-foxp3 fusion construct modulate treg-cell-mediated suppression ha-tag-generating pmt2-ha-foxp3 impaired treg-cell-mediated suppression regulate treg-cell-mediated suppression preventing treg-cell-mediated suppression decreased treg-cell-mediated suppression x-chromosome-linked syndrome specific pathogen-free conditions treg-cell-mediated immune modulation anti-cd3 anti-cd28 dynabeads treg-cell-mediated suppression mouse anti-flag m2 treated ha-foxp3-transfected cells van der horst ubi-foxp3 fusion protein naΓ―ve cd4+cd25βcd62lhigh pmc beta search insulin-dependent diabetes mellitus radioactive labeled flag-foxp3 polyubiquitination-mediated proteosomal degradation siusp7-transduced treg cells hausp-mediated deubiquitination contributes magnetic-activated cell sorting dna damage-induced destabilization usp7-mediated deubiquitination results cd4+gfp+ cell numbers supplementary materials included puromycin-resistant treg cells ubiquitin hydrolase uch-l1 tandem ubiquitin-binding entities genome-wide association study regulatory t-cell functions cd4+cd25+ treg cells numerous single-nucleotide polymorphisms eosin-stained tissue slides foxp3 gfp-cre mice foxp3-ires-gfp mice anti-ha-coupled beads foxp3-dependent developmental program foxp3-gfp promoter mice anti-myc-coupled beads stat5-signaling cytokines regulate rapid proteasome-mediated degradation anti-cd3-coated wells ubiquitin fusion protein myc-usp7-transfected cells 1 Γ106 cd4+cd25βcd62lhigh regulatory t-cell differentiation
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Analytics and Tracking {π}
- Google Analytics
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