
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Foxp3 exploits a preexistent enhancer landscape for regulatory T cell lineage specification - PMC
Description:
Regulatory T (Treg) cells, whose identity and function are defined by the transcription factor Foxp3, are indispensable for immune homeostasis. It is unclear whether Foxp3 exerts its Treg lineage specification function through active modification of ...
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Keywords {๐}
foxp, cells, treg, sites, doi, binding, cell, expression, enhancers, chromatin, google, scholar, pubmed, figure, precursor, genes, gene, pmc, article, transcription, regulatory, accessibility, differentiation, bound, foxo, free, analysis, accessible, motif, motifs, function, chipseq, cofactors, tregspecific, activation, factors, dna, loci, dnaseseq, peaks, enriched, ets, factor, foxpcd, enhancer, tcr, genomewide, dhss, data, found,
Topics {โ๏ธ}
auto-regulatory feed-forward loop van der vliet strand-specific 75nt shift x-chromosome encoded member pmc beta search experimental procedures mice treg-specific dhs loci exclusively treg cell-specific late-acting differentiation factor genome-wide nucleotide frequencies recent genome-wide studies genome-wide association studies multiple chip-seq experiments genome-wide dnase-seq b-cell-specific sites domain-swapped foxp3 dimer apparently treg-specific enhancers seemingly treg-specific enhancers disrupts protein-protein interactions genome-wide dhs landscape seemingly treg-specific sites specific dna-protein interactions recent study showing ๏ฟฝtreg-specificโ dhs sites treg-specific dhs sites aml1/runx-1 runt domain treg-specific enhancers including genome-wide dhs sites x-ray crystallographic analysis pre-existing enhancer landscape treg-specific dnase sites dnase-seq technology offers genome-wide enhancer analysis glucocorticoid receptor binding foxp3-dependent developmental program genome-wide chromatin accessibility regulatory t-cell fate genome-wide binding sites performed dnase-seq analysis dnase-seq reads aligned performed chip-seq analysis foxo1 chip-seq reads chip-seq reads aligned supplementary materials included regulatory t-cell differentiation foxp3 chip-seq experiments late differentiation process sequence patterns showed chromatin-immunoprecipitation microarray experiments foxp3-independent cofactor binding
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