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We are analyzing https://stemcellres.biomedcentral.com/articles/10.1186/s13287-024-04127-y.

Title:
Mesenchymal stem cell therapy as a game-changer in liver diseases: review of current clinical trials | Stem Cell Research & Therapy | Full Text
Description:
Chronic liver diseases, including cirrhosis and liver failure, remain formidable challenges due to their complex progression and limited therapeutic options. Mesenchymal stem cell (MSC) therapy has emerged as a game-changing approach, leveraging its potent immunomodulatory, anti-fibrotic, and regenerative capabilities, along with the ability to transdifferentiate into hepatocytes. This review delves into the latest advances in MSC-based treatments for chronic and end-stage liver diseases, as highlighted in current clinical trials. MSCs derived from bone marrow and umbilical cord have shown remarkable promise in reversing liver damage, improving liver function, and providing hope for patients who do not respond to conventional therapies. When administered through hepatic, portal, or peripheral veins, MSCs have significantly improved liver histology, reduced fibrosis, and restored functional capacity. Furthermore, MSC-derived materials, such as extracellular vesicles and exosomes, are emerging as cutting-edge tools for treating liver failure and mitigating post-transplant complications. While autologous MSC-derived hepatocytes hold promise for non-fatal cirrhosis, allogeneic MSCs are being applied in more severe conditions, including liver failure and transplantation cases. Despite these promising early outcomes, larger trials and long-term studies are essential to fully harness MSCs as a transformative, off-the-shelf alternative to liver transplantation, heralding a new era in regenerative liver therapies.
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25 years and 10 months (reg. 1999-08-06).

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Keywords {🔍}

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Topics {✒️}

adipose-derived stromal/stem cells decreasing tlr2/nf-kappab signaling myeloid-derived suppressor cell myeloid-derived suppressor cells hepatocyte growth factor/c-met umbilical cord-derived sources mesenchymal stromal/stem cells drug-induced liver injury end-stage liver disease mesenchymal stem cell-mediated end-stage liver diseases α-smooth muscle actin myeloid-derived suppressive phenotype placenta-derived multipotent cells monocyte-derived dendritic cells placenta-derived stem cells downregulating t-bet expression tri-service general hospital kynurenine-ahr-nrf2 pathway induce cd4 + cd25highfoxp3 + regulatory pi3k/akt/mtor pathway transforming growth factor-β1 utilizing cell-free products including anti-inflammatory cytokines biliary-specific inflammatory disease disease-related liver injury abo-incompatible liver transplantation cd4 + cd25 + foxp3 + regulatory mesenchymal stromal cells growth-regulated oncogene-γ [69] growth-regulated oncogene-γ inflammation-mediated liver diseases mesenchymal stem cell msc-derived prostaglandin e2 additional information publisher including bone marrow multipotent stromal cells growth-regulated oncogene chemokines vitro msc-mediated inhibition interleukin-1 receptor antagonist mesenchymal stem cells mesenchymal stem cells standard liver-supportive treatment increase il-10-expressing regulatory neutrophil-mediated tissue damage cell stem cell allogenic msc-based trials heme oxygenase-1-mediated induction egyptian hcv-positive patients hepatic transdifferentiation

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