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Keywords {🔍}

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Topics {✒️}

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Questions {❓}

• Adult stem cells for tissue repair - a new therapeutic concept?
• Concise review: adult mesenchymal stromal cell therapy for inflammatory diseases: how well are we joining the dots?
• Do cryopreserved mesenchymal stromal cells display impaired immunomodulatory and therapeutic properties?
• Mesenchymal stem cell treatments in rheumatology: a glass half full?
• Multipotent mesenchymal stromal cells and rheumatoid arthritis: risk or benefit?
• The mesenchymal stromal cells dilemma--does a negative phase III trial of random donor mesenchymal stromal cells in steroid-resistant graft-versus-host disease represent a death knell or a bump in the road?

Schema {🗺️}

WebPage:
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         headline:Human mesenchymal stem cells (MSCs) for treatment towards immune- and inflammation-mediated diseases: review of current clinical trials
         description:Human mesenchymal stem cells (MSCs) are multilineage somatic progenitor/stem cells that have been shown to possess immunomodulatory properties in recent years. Initially met with much skepticism, MSC immunomodulation has now been well reproduced across tissue sources and species to be clinically relevant. This has opened up the use of these versatile cells for application as 3rd party/allogeneic use in cell replacement/tissue regeneration, as well as for immune- and inflammation-mediated disease entities. Most surprisingly, use of MSCs for in immune-/inflammation-mediated diseases appears to yield more efficacy than for regenerative medicine, since engraftment of the exogenous cell does not appear necessary. In this review, we focus on this non-traditional clinical use of a tissue-specific stem cell, and highlight important findings and trends in this exciting area of stem cell therapy.
         datePublished:2016-11-04T00:00:00Z
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            Human
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      headline:Human mesenchymal stem cells (MSCs) for treatment towards immune- and inflammation-mediated diseases: review of current clinical trials
      description:Human mesenchymal stem cells (MSCs) are multilineage somatic progenitor/stem cells that have been shown to possess immunomodulatory properties in recent years. Initially met with much skepticism, MSC immunomodulation has now been well reproduced across tissue sources and species to be clinically relevant. This has opened up the use of these versatile cells for application as 3rd party/allogeneic use in cell replacement/tissue regeneration, as well as for immune- and inflammation-mediated disease entities. Most surprisingly, use of MSCs for in immune-/inflammation-mediated diseases appears to yield more efficacy than for regenerative medicine, since engraftment of the exogenous cell does not appear necessary. In this review, we focus on this non-traditional clinical use of a tissue-specific stem cell, and highlight important findings and trends in this exciting area of stem cell therapy.
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      dateModified:2016-11-04T00:00:00Z
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         Human
         Immunomodulation
         Inflammation
         Clinical trials
         Autoimmune disease
         Organ transplantation and rejection
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         general
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                  address:
                     name:Department of Ob/Gyn, National Taiwan University Hospital & College of Medicine, National Taiwan University, Taipei, Taiwan
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            name:Institute of Cellular & System Medicine, National Health Research Institutes (NHRI)
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      name:Regenerative Medicine Research Group, Institute of Cellular & System Medicine, National Health Research Institutes (NHRI), Zhunan, Taiwan
      name:Department of Ob/Gyn, National Taiwan University Hospital & College of Medicine, National Taiwan University, Taipei, Taiwan
      name:National Institute of Cancer Research, NHRI, Tainan, Taiwan
      name:Graduate Institute of Life Sciences, National Defense Medical Center (NDMC), Taipei, Taiwan
      name:Graduate Institute of Microbiology and Immunology, NDMC, Taipei, Taiwan
      name:Regenerative Medicine Research Group, Institute of Cellular & System Medicine, National Health Research Institutes (NHRI), Zhunan, Taiwan
      name:Graduate Institute of Basic Medical Sciences, China Medical College, Taichung, Taiwan
      name:Regenerative Medicine Research Group, Institute of Cellular & System Medicine, National Health Research Institutes (NHRI), Zhunan, Taiwan

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