
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Mesenchymal stem cell repression of Th17 cells is triggered by mitochondrial transfer - PMC
Description:
Mesenchymal stem cells (MSCs) are multipotent cells with broad immunosuppressive capacities. Recently, it has been reported that MSCs can transfer mitochondria to various cell types, including fibroblast, cancer, and endothelial cells. It has been ...
Matching Content Categories {📚}
- Science
- Careers
- Telecommunications
Content Management System {📝}
What CMS is ncbi.nlm.nih.gov built with?
Custom-built
No common CMS systems were detected on Ncbi.nlm.nih.gov, and no known web development framework was identified.
Traffic Estimate {📈}
What is the average monthly size of ncbi.nlm.nih.gov audience?
🌠 Phenomenal Traffic: 5M - 10M visitors per month
Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Ncbi.nlm.nih.gov Make Money? {💸}
We don't see any clear sign of profit-making.
Not all websites are made for profit; some exist to inform or educate users. Or any other reason why people make websites. And this might be the case. Ncbi.nlm.nih.gov might have a hidden revenue stream, but it's not something we can detect.
Keywords {🔍}
cells, cell, transfer, bmmscs, mitochondrial, mitochondria, doi, mscs, coculture, stem, fig, pubmed, google, scholar, pmc, donors, msc, article, mesenchymal, free, mitoception, bmmsc, human, data, healthy, cocultured, function, treg, flow, isolated, activation, mito, effect, foxp, cytometry, expression, mitotracker, results, phenotype, proliferation, france, analysis, tnfα, experiments, quantification, rasmscs, artificial, metabolic, metabolism, ifnγ,
Topics {✒️}
interleukin-1beta-dependent glycolytic pathway oxidative phosphorylation nitric oxide 3-dioxygenase pha related inos il-6-dependent pge2 secretion increases oxygen consumption oxygen consumption rates pi3k/akt/mtorc1 signaling pathway oxygen consumption increase increased oxygen consumption bm-msc mitochondrial dna rheumatoid arthritis tnf-α/ifn-γ stimulation proliferation rate tnf-α/ifn-γ activation primary human cd4+ccr6+cd45r0+ oxidative stress prostaglandin e2 tnf-α/ifn-γ pbmc donors anti-ifn-γ–apccy7 chemokine receptor ccr6 anti-foxp3 pe-conjugated mab arthritis res ther anti-cd28 antibody-coated beads mitotracker-labeled bm-mscs pre-activated induce cd4+cd25highfoxp3+ regulatory pbmc prostaglandin tnt-mediated transfer mitochondrial dna anti-cd28 monoclonal antibody il-23 receptor variable d-loop regions high-throughput sanger strategy mesenchymal stem cells pmc beta search reactive oxygen species mitochondrial rho-gtpase miro regulatory cell phenotype pe-conjugated anti-ccr6 anti-cd3/cd28 antibodies parametric mann–whitney test tissue-resident immune cells fluo-conjugated anti-cd3 facs-sorted cd4+ccr6+cd45ro+ cell ocr values
Social Networks {👍}(6)
External Links {🔗}(82)
- How much revenue does https://doi.org/10.1186/s13287-019-1307-9 generate?
- What are the total earnings of http://creativecommons.org/licenses/by/4.0/?
- Find out how much http://creativecommons.org/publicdomain/zero/1.0/ earns monthly
- How much profit is https://doi.org/10.1038/nrrheum.2009.104 making per month?
- What's the financial intake of https://scholar.google.com/scholar_lookup?journal=Nat%20Rev%20Rheumatol&title=Mesenchymal%20stem%20cells:%20innovative%20therapeutic%20tools%20for%20rheumatic%20diseases&author=F%20Djouad&author=C%20Bouffi&author=S%20Ghannam&author=D%20Noel&author=C%20Jorgensen&volume=5&issue=7&publication_year=2009&pages=392-399&pmid=19568253&doi=10.1038/nrrheum.2009.104&?
- https://doi.org/10.3389/fimmu.2018.01658's total income per month
- What are the earnings of https://scholar.google.com/scholar_lookup?journal=Front%20Immunol&title=Critical%20role%20of%20tumor%20necrosis%20factor%20signaling%20in%20mesenchymal%20stem%20cell-based%20therapy%20for%20autoimmune%20and%20inflammatory%20diseases&author=L%20Yan&author=D%20Zheng&author=RH%20Xu&volume=9&publication_year=2018&pages=1658&pmid=30079066&doi=10.3389/fimmu.2018.01658&?
- Profit of https://doi.org/10.1007/978-3-319-54090-0_4
- What are the total earnings of https://scholar.google.com/scholar_lookup?journal=Results%20Probl%20Cell%20Differ&title=Mesenchymal%20stem%20cells%20direct%20the%20immunological%20fate%20of%20macrophages&author=P%20Luz-Crawford&author=C%20Jorgensen&author=F%20Djouad&volume=62&publication_year=2017&pages=61-72&pmid=28455706&doi=10.1007/978-3-319-54090-0_4&?
- What's the total monthly financial gain of https://doi.org/10.1038/cdd.2013.149?
- See how much https://scholar.google.com/scholar_lookup?journal=Cell%20Death%20Differ&title=Phylogenetic%20distinction%20of%20iNOS%20and%20IDO%20function%20in%20mesenchymal%20stem%20cell-mediated%20immunosuppression%20in%20mammalian%20species&author=J%20Su&author=X%20Chen&author=Y%20Huang&author=W%20Li&author=J%20Li&volume=21&issue=3&publication_year=2014&pages=388-396&pmid=24162664&doi=10.1038/cdd.2013.149& makes per month
- Get to know https://doi.org/10.1002/eji.200425405's earnings
- How much does https://scholar.google.com/scholar_lookup?journal=Eur%20J%20Immunol&title=Bone%20marrow%20mesenchymal%20progenitor%20cells%20inhibit%20lymphocyte%20proliferation%20by%20activation%20of%20the%20programmed%20death%201%20pathway&author=A%20Augello&author=R%20Tasso&author=SM%20Negrini&author=A%20Amateis&author=F%20Indiveri&volume=35&issue=5&publication_year=2005&pages=1482-1490&pmid=15827960&doi=10.1002/eji.200425405& pull in?
- Financial intake of https://doi.org/10.1371/journal.pone.0014247
- What's the monthly income of https://scholar.google.com/scholar_lookup?journal=PLoS%20One&title=IL-6-dependent%20PGE2%20secretion%20by%20mesenchymal%20stem%20cells%20inhibits%20local%20inflammation%20in%20experimental%20arthritis&author=C%20Bouffi&author=C%20Bony&author=G%20Courties&author=C%20Jorgensen&author=D%20Noel&volume=5&issue=12&publication_year=2010&pages=e14247&pmid=21151872&doi=10.1371/journal.pone.0014247&?
- How much does https://doi.org/10.1111/j.1365-2249.2009.03874.x make?
- What's the monthly income of https://scholar.google.com/scholar_lookup?journal=Clin%20Exp%20Immunol&title=Cell%20contact,%20prostaglandin%20E(2)%20and%20transforming%20growth%20factor%20beta%201%20play%20non-redundant%20roles%20in%20human%20mesenchymal%20stem%20cell%20induction%20of%20CD4+CD25(high)%20forkhead%20box%20P3+%20regulatory%20T%20cells&author=K%20English&author=JM%20Ryan&author=L%20Tobin&author=MJ%20Murphy&author=FP%20Barry&volume=156&issue=1&publication_year=2009&pages=149-160&pmid=19210524&doi=10.1111/j.1365-2249.2009.03874.x&?
- What's the monthly income of https://doi.org/10.1634/stemcells.2007-0554?
- How much does https://scholar.google.com/scholar_lookup?journal=Stem%20Cells&title=Human%20leukocyte%20antigen-G5%20secretion%20by%20human%20mesenchymal%20stem%20cells%20is%20required%20to%20suppress%20T%20lymphocyte%20and%20natural%20killer%20function%20and%20to%20induce%20CD4+CD25highFOXP3+%20regulatory%20T%20cells&author=Z%20Selmani&author=A%20Naji&author=I%20Zidi&author=B%20Favier&author=E%20Gaiffe&volume=26&issue=1&publication_year=2008&pages=212-222&pmid=17932417&doi=10.1634/stemcells.2007-0554& pull in monthly?
- Learn how profitable https://doi.org/10.4049/jimmunol.0902007 is on a monthly basis
- What's the income of https://scholar.google.com/scholar_lookup?journal=J%20Immunol&title=Mesenchymal%20stem%20cells%20inhibit%20human%20Th17%20cell%20differentiation%20and%20function%20and%20induce%20a%20T%20regulatory%20cell%20phenotype&author=S%20Ghannam&author=J%20Pene&author=G%20Torcy-Moquet&author=C%20Jorgensen&author=H%20Yssel&volume=185&issue=1&publication_year=2010&pages=302-312&pmid=20511548&doi=10.4049/jimmunol.0902007&?
- How much profit is https://doi.org/10.5966/sctm.2015-0243 making per month?
- What's the financial gain of https://scholar.google.com/scholar_lookup?journal=Stem%20Cells%20Transl%20Med&title=Human%20mesenchymal%20stem%20cells%20impact%20Th17%20and%20Th1%20responses%20through%20a%20prostaglandin%20E2%20and%20myeloid-dependent%20mechanism&author=A%20Rozenberg&author=A%20Rezk&author=MN%20Boivin&author=PJ%20Darlington&author=M%20Nyirenda&volume=5&issue=11&publication_year=2016&pages=1506-1514&pmid=27400792&doi=10.5966/sctm.2015-0243&?
- Get to know https://doi.org/10.1371/journal.pone.0045272's earnings
- How much does https://scholar.google.com/scholar_lookup?journal=PLoS%20One&title=Mesenchymal%20stem%20cells%20repress%20Th17%20molecular%20program%20through%20the%20PD-1%20pathway&author=P%20Luz-Crawford&author=D%20Noel&author=X%20Fernandez&author=M%20Khoury&author=F%20Figueroa&volume=7&issue=9&publication_year=2012&pages=e45272&pmid=23028899&doi=10.1371/journal.pone.0045272& net monthly?
- How much does https://doi.org/10.1182/blood-2003-04-1193 pull in monthly?
- How much does https://scholar.google.com/scholar_lookup?journal=Blood&title=Immunosuppressive%20effect%20of%20mesenchymal%20stem%20cells%20favors%20tumor%20growth%20in%20allogeneic%20animals&author=F%20Djouad&author=P%20Plence&author=C%20Bony&author=P%20Tropel&author=F%20Apparailly&volume=102&issue=10&publication_year=2003&pages=3837-3844&pmid=12881305&doi=10.1182/blood-2003-04-1193& make?
- Income figures for https://doi.org/10.4049/jimmunol.0902023
- How much profit does https://scholar.google.com/scholar_lookup?journal=J%20Immunol&title=Inflammatory%20cytokine-induced%20intercellular%20adhesion%20molecule-1%20and%20vascular%20cell%20adhesion%20molecule-1%20in%20mesenchymal%20stem%20cells%20are%20critical%20for%20immunosuppression&author=G%20Ren&author=X%20Zhao&author=L%20Zhang&author=J%20Zhang&author=A%20L'Huillier&volume=184&issue=5&publication_year=2010&pages=2321-2328&pmid=20130212&doi=10.4049/jimmunol.0902023& make?
- Explore the financials of https://doi.org/10.1016/j.imlet.2007.04.001
- Learn about the earnings of https://scholar.google.com/scholar_lookup?journal=Immunol%20Lett&title=IFN-gamma%20and%20TNF-alpha%20differentially%20regulate%20immunomodulation%20by%20murine%20mesenchymal%20stem%20cells&author=K%20English&author=FP%20Barry&author=CP%20Field-Corbett&author=BP%20Mahon&volume=110&issue=2&publication_year=2007&pages=91-100&pmid=17507101&doi=10.1016/j.imlet.2007.04.001&
- Revenue of https://doi.org/10.3791/55245
- What are the earnings of https://doi.org/10.1002/embj.201386030?
- https://scholar.google.com/scholar_lookup?journal=EMBO%20J&title=Miro1%20regulates%20intercellular%20mitochondrial%20transport%20&%20enhances%20mesenchymal%20stem%20cell%20rescue%20efficacy&author=T%20Ahmad&author=S%20Mukherjee&author=B%20Pattnaik&author=M%20Kumar&author=S%20Singh&volume=33&issue=9&publication_year=2014&pages=994-1010&pmid=24431222&doi=10.1002/embj.201386030&'s financial summary
- Profit of https://doi.org/10.1038/srep09073
- What's the total monthly financial gain of https://scholar.google.com/scholar_lookup?journal=Sci%20Rep&title=MitoCeption%20as%20a%20new%20tool%20to%20assess%20the%20effects%20of%20mesenchymal%20stem/stromal%20cell%20mitochondria%20on%20cancer%20cell%20metabolism%20and%20function&author=A%20Caicedo&author=V%20Fritz&author=JM%20Brondello&author=M%20Ayala&author=I%20Dennemont&volume=5&publication_year=2015&pages=9073&pmid=25766410&doi=10.1038/srep09073&?
- How much does https://doi.org/10.3390/molecules23030687 make?
- Income figures for https://scholar.google.com/scholar_lookup?journal=Molecules&title=Miro1%20Enhances%20Mitochondria%20Transfer%20from%20Multipotent%20Mesenchymal%20Stem%20Cells%20(MMSC)%20to%20Neural%20Cells%20and%20Improves%20the%20Efficacy%20of%20Cell%20Recovery&author=Valentina%20Babenko&author=Denis%20Silachev&author=Vasily%20Popkov&author=Ljubava%20Zorova&author=Irina%20Pevzner&volume=23&issue=3&publication_year=2018&pages=687&pmid=29562677&doi=10.3390/molecules23030687&
- What's the financial outcome of https://doi.org/10.1186/s12929-018-0429-1?
- What's https://scholar.google.com/scholar_lookup?journal=J%20Biomed%20Sci&title=Regenerative%20abilities%20of%20mesenchymal%20stem%20cells%20through%20mitochondrial%20transfer&author=S%20Paliwal&author=R%20Chaudhuri&author=A%20Agrawal&author=S%20Mohanty&volume=25&issue=1&publication_year=2018&pages=31&pmid=29602309&doi=10.1186/s12929-018-0429-1&'s gross income?
- https://doi.org/10.1186/s13287-018-1012-0's financial summary
- Financial intake of https://scholar.google.com/scholar_lookup?journal=Stem%20Cell%20Res%20Ther&title=Human%20tissue-specific%20MSCs%20demonstrate%20differential%20mitochondria%20transfer%20abilities%20that%20may%20determine%20their%20regenerative%20abilities&author=S%20Paliwal&author=R%20Chaudhuri&author=A%20Agrawal&author=S%20Mohanty&volume=9&issue=1&publication_year=2018&pages=298&pmid=30409230&doi=10.1186/s13287-018-1012-0&
- Learn how profitable https://doi.org/10.1186/ar1827 is on a monthly basis
- What's the revenue for https://scholar.google.com/scholar_lookup?journal=Arthritis%20Res%20Ther&title=Transcriptional%20profiles%20discriminate%20bone%20marrow-derived%20and%20synovium-derived%20mesenchymal%20stem%20cells&author=F%20Djouad&author=C%20Bony&author=T%20Haupl&author=G%20Uze&author=N%20Lahlou&volume=7&issue=6&publication_year=2005&pages=R1304-R1315&pmid=16277684&doi=10.1186/ar1827&?
- How much does https://doi.org/10.1186/1471-2164-14-881 generate monthly?
- See how much https://scholar.google.com/scholar_lookup?journal=BMC%20Genomics&title=A%20high-throughput%20Sanger%20strategy%20for%20human%20mitochondrial%20genome%20sequencing&author=EA%20Lyons&author=MK%20Scheible&author=K%20Sturk-Andreaggi&author=JA%20Irwin&author=RS%20Just&volume=14&publication_year=2013&pages=881&pmid=24341507&doi=10.1186/1471-2164-14-881& makes per month
- How much income does https://doi.org/10.1186/s13045-018-0554-z have?
- Get to know https://scholar.google.com/scholar_lookup?journal=J%20Hematol%20Oncol&title=Cell%20adhesion-mediated%20mitochondria%20transfer%20contributes%20to%20mesenchymal%20stem%20cell-induced%20chemoresistance%20on%20T%20cell%20acute%20lymphoblastic%20leukemia%20cells&author=J%20Wang&author=X%20Liu&author=Y%20Qiu&author=Y%20Shi&author=J%20Cai&volume=11&issue=1&publication_year=2018&pages=11&pmid=29357914&doi=10.1186/s13045-018-0554-z&'s earnings
- Earnings of https://doi.org/10.1016/S1074-7613(02)00323-0
- What are the total earnings of https://scholar.google.com/scholar_lookup?journal=Immunity&title=The%20CD28%20signaling%20pathway%20regulates%20glucose%20metabolism&author=KA%20Frauwirth&author=JL%20Riley&author=MH%20Harris&author=RV%20Parry&author=JC%20Rathmell&volume=16&issue=6&publication_year=2002&pages=769-777&pmid=12121659&doi=10.1016/S1074-7613(02)00323-0&?
- How much income is https://doi.org/10.1016/j.immuni.2017.04.028 earning monthly?
- What is the monthly revenue of https://scholar.google.com/scholar_lookup?journal=Immunity&title=MenTORing%20immunity:%20mTOR%20signaling%20in%20the%20development%20and%20function%20of%20tissue-resident%20immune%20cells&author=RG%20Jones&author=EJ%20Pearce&volume=46&issue=5&publication_year=2017&pages=730-742&pmid=28514674&doi=10.1016/j.immuni.2017.04.028&?
- How much money does https://doi.org/10.1038/ni.3577 make?
- What's the income generated by https://scholar.google.com/scholar_lookup?journal=Nat%20Immunol&title=Foxp3%20and%20Toll-like%20receptor%20signaling%20balance%20Treg%20cell%20anabolic%20metabolism%20for%20suppression&author=VA%20Gerriets&author=RJ%20Kishton&author=MO%20Johnson&author=S%20Cohen&author=PJ%20Siska&volume=17&issue=12&publication_year=2016&pages=1459-1466&pmid=27695003&doi=10.1038/ni.3577& each month?
- How much does https://doi.org/10.1111/j.1600-065X.2012.01150.x net monthly?
- https://scholar.google.com/scholar_lookup?journal=Immunol%20Rev&title=Metabolic%20switching%20and%20fuel%20choice%20during%20T-cell%20differentiation%20and%20memory%20development&author=GJ%20van%20der%20Windt&author=EL%20Pearce&volume=249&issue=1&publication_year=2012&pages=27-42&pmid=22889213&doi=10.1111/j.1600-065X.2012.01150.x&'s total income per month
- What's the revenue for https://doi.org/10.1016/j.cell.2016.08.064?
- How much does https://scholar.google.com/scholar_lookup?journal=Cell&title=Succinate%20dehydrogenase%20supports%20metabolic%20repurposing%20of%20mitochondria%20to%20drive%20inflammatory%20macrophages&author=EL%20Mills&author=B%20Kelly&author=A%20Logan&author=ASH%20Costa&author=M%20Varma&volume=167&issue=2&publication_year=2016&pages=457-470&pmid=27667687&doi=10.1016/j.cell.2016.08.064& bring in each month?
- How much revenue does https://doi.org/10.1038/ni.2386 produce monthly?
- How much does https://scholar.google.com/scholar_lookup?journal=Nat%20Immunol&title=Metabolic%20checkpoints%20in%20activated%20T%20cells&author=R%20Wang&author=DR%20Green&volume=13&issue=10&publication_year=2012&pages=907-915&pmid=22990888&doi=10.1038/ni.2386& earn?
- What's https://doi.org/10.1155/2015/631384's gross income?
- Get to know what's the income of https://scholar.google.com/scholar_lookup?journal=Mediat%20Inflamm&title=IL-1%20receptor%20blockade%20alleviates%20graft-versus-host%20disease%20through%20downregulation%20of%20an%20interleukin-1beta-dependent%20glycolytic%20pathway%20in%20Th17%20cells&author=MJ%20Park&author=SH%20Lee&author=SH%20Lee&author=EJ%20Lee&author=EK%20Kim&volume=2015&publication_year=2015&pages=631384&pmid=26798206&doi=10.1155/2015/631384&
- How profitable is https://doi.org/10.1084/jem.20110278?
- Check the income stats for https://scholar.google.com/scholar_lookup?journal=J%20Exp%20Med&title=HIF1alpha-dependent%20glycolytic%20pathway%20orchestrates%20a%20metabolic%20checkpoint%20for%20the%20differentiation%20of%20TH17%20and%20Treg%20cells&author=LZ%20Shi&author=R%20Wang&author=G%20Huang&author=P%20Vogel&author=G%20Neale&volume=208&issue=7&publication_year=2011&pages=1367-1376&pmid=21708926&doi=10.1084/jem.20110278&
- What is the monthly revenue of https://doi.org/10.1136/annrheumdis-2015-208476?
- How much money does https://scholar.google.com/scholar_lookup?journal=Ann%20Rheum%20Dis&title=Dysregulated%20bioenergetics:%20a%20key%20regulator%20of%20joint%20inflammation&author=M%20Biniecka&author=M%20Canavan&author=T%20McGarry&author=W%20Gao&author=J%20McCormick&volume=75&issue=12&publication_year=2016&pages=2192-2200&pmid=27013493&doi=10.1136/annrheumdis-2015-208476& make?
- How much does https://doi.org/10.1186/1471-2474-12-42 net monthly?
- Explore the financials of https://scholar.google.com/scholar_lookup?journal=BMC%20Musculoskelet%20Disord&title=Effect%20of%20nitric%20oxide%20on%20mitochondrial%20activity%20of%20human%20synovial%20cells&author=B%20Cillero-Pastor&author=MA%20Martin&author=J%20Arenas&author=MJ%20Lopez-Armada&author=FJ%20Blanco&volume=12&publication_year=2011&pages=42&pmid=21303534&doi=10.1186/1471-2474-12-42&
- https://doi.org/10.1155/2016/4062789's financial summary
- What is the monthly revenue of https://scholar.google.com/scholar_lookup?journal=Stem%20Cells%20Int&title=Umbilical%20cord-derived%20mesenchymal%20stem%20cells%20suppress%20autophagy%20of%20T%20cells%20in%20patients%20with%20systemic%20lupus%20erythematosus%20via%20transfer%20of%20mitochondria&author=J%20Chen&author=Q%20Wang&author=X%20Feng&author=Z%20Zhang&author=L%20Geng&volume=2016&publication_year=2016&pages=4062789&pmid=28053607&doi=10.1155/2016/4062789&?
- Get to know what's the income of https://github.com/ncbi
- Check the income stats for https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/%4038.9959508, -77.101021,17z/data%3D!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb%3A0x19156f88b27635b8!8m2!3d38.9959508! 4d-77.0988323
- How much does https://www.nlm.nih.gov/web_policies.html rake in every month?
- How much does https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office rake in every month?
- How much money does https://www.hhs.gov/vulnerability-disclosure-policy/index.html make?
- How much does https://support.nlm.nih.gov/?pagename=cloudpmc-viewer%3Apmc%3Aarticle%3Ajournal make?
- How much revenue does https://www.nlm.nih.gov/accessibility.html bring in?
- What's the monthly income of https://www.nlm.nih.gov/careers/careers.html?
- https://www.nlm.nih.gov/'s revenue stream
- How much does https://www.nih.gov/ pull in monthly?
- What's the total monthly financial gain of https://www.hhs.gov/?
- How much profit does https://www.usa.gov/ make?
Analytics and Tracking {📊}
- Google Analytics
- Google Analytics 4
- Google Tag Manager
Libraries {📚}
- jQuery
- jQuery module (jquery-3.6.0)
- Zoom.js
Emails and Hosting {✉️}
Mail Servers:
- nihcesxway.hub.nih.gov
- nihcesxway2.hub.nih.gov
- nihcesxway3.hub.nih.gov
- nihcesxway4.hub.nih.gov
- nihcesxway5.hub.nih.gov
Name Servers:
- dns1-ncbi.ncbi.nlm.nih.gov
- dns2-ncbi.ncbi.nlm.nih.gov
- lhcns1.nlm.nih.gov
- lhcns2.nlm.nih.gov
CDN Services {📦}
- Ncbi