We are analyzing https://link.springer.com/article/10.1186/s41232-019-0107-z.

Title:
Mesenchymal stem cell therapies for liver cirrhosis: MSCs as “conducting cells” for improvement of liver fibrosis and regeneration | Inflammation and Regeneration
Description:
Mesenchymal stem cells (MSCs) can be cultured relatively easily and can be obtained not only from the bone marrow, but also from medical waste such as adipose tissue and umbilical cord tissue. Because of its low antigenicity, allogeneic MSC injection is safe. MSCs have been evaluated in more than 900 clinical trials in a variety of fields, with more than 50 clinical trials related to liver diseases. Experiments have suggested that MSCs function as “conducting cells” to affect various “effective cells” such as T cells, B cells, and macrophages. Recent clinical trials have focused on allogeneic MSCs. Thus, studies are needed to determine the most effective cell source, culture conditions, cell numbers, administration frequency, administration route, cost, safety, and liver disease treatments. Recently, the functions of exosomes have gained attention, and cell-free therapy may become possible as an alternative therapy for liver disease. In this review, we introduce general information, mechanism, representative clinical study data, recently started or planned clinical trials, and possibility of cell-free therapy of MSCs.
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Keywords {🔍}

liver, cells, mscs, article, cell, stem, google, scholar, clinical, mesenchymal, therapy, trials, bone, cirrhosis, cases, macrophages, cas, studies, exosomes, function, msc, disease, effects, therapies, fibrosis, administration, diseases, reported, autologous, marrow, recently, failure, acute, patients, allogeneic, recent, study, tissue, hepatic, chronic, extracellular, injury, hepatitis, marrowderived, res, research, published, tsuchiya, terai, effective,

Topics {✒️}

bone-marrow-derived cells cultured bone marrow-derived cells carbon-tetrachloride-treated cirrhotic mice bone marrow-derived macrophages include endosome-derived components bone marrow-derived mscs mesenchymal stromal cells mesenchymal stem cells hepatic stellate cells stem cell therapy umbilical cord tissue drug-induced liver injury article download pdf hepatic failure induced green fluorescent protein-labeled achieve anti-inflammation effects long-term outcomes mscs exhibit anti-inflammation stem cells int human liver diseases cell-free therapy bone marrow origin improve liver fibrosis lethal hepatic failure privacy choices/manage cookies metabolic syndromes induced attractive cell therapies recent research trends planned clinical trials full access replace damaged cells biological effects induced recently published outcomes cell tissue res cell type-specific improve liver function msc-derived exosomes proposed diagnostic criteria creative commons license stem cells multiple organ failure msc-based therapy recent clinical trials chronic liver failure chronic liver failure child-pugh scores serum total bilirubin allogenic msc therapies msc therapy appears exp mol med

Schema {🗺️}

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         headline:Mesenchymal stem cell therapies for liver cirrhosis: MSCs as “conducting cells” for improvement of liver fibrosis and regeneration
         description:Mesenchymal stem cells (MSCs) can be cultured relatively easily and can be obtained not only from the bone marrow, but also from medical waste such as adipose tissue and umbilical cord tissue. Because of its low antigenicity, allogeneic MSC injection is safe. MSCs have been evaluated in more than 900 clinical trials in a variety of fields, with more than 50 clinical trials related to liver diseases. Experiments have suggested that MSCs function as “conducting cells” to affect various “effective cells” such as T cells, B cells, and macrophages. Recent clinical trials have focused on allogeneic MSCs. Thus, studies are needed to determine the most effective cell source, culture conditions, cell numbers, administration frequency, administration route, cost, safety, and liver disease treatments. Recently, the functions of exosomes have gained attention, and cell-free therapy may become possible as an alternative therapy for liver disease. In this review, we introduce general information, mechanism, representative clinical study data, recently started or planned clinical trials, and possibility of cell-free therapy of MSCs.
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      headline:Mesenchymal stem cell therapies for liver cirrhosis: MSCs as “conducting cells” for improvement of liver fibrosis and regeneration
      description:Mesenchymal stem cells (MSCs) can be cultured relatively easily and can be obtained not only from the bone marrow, but also from medical waste such as adipose tissue and umbilical cord tissue. Because of its low antigenicity, allogeneic MSC injection is safe. MSCs have been evaluated in more than 900 clinical trials in a variety of fields, with more than 50 clinical trials related to liver diseases. Experiments have suggested that MSCs function as “conducting cells” to affect various “effective cells” such as T cells, B cells, and macrophages. Recent clinical trials have focused on allogeneic MSCs. Thus, studies are needed to determine the most effective cell source, culture conditions, cell numbers, administration frequency, administration route, cost, safety, and liver disease treatments. Recently, the functions of exosomes have gained attention, and cell-free therapy may become possible as an alternative therapy for liver disease. In this review, we introduce general information, mechanism, representative clinical study data, recently started or planned clinical trials, and possibility of cell-free therapy of MSCs.
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         Acute on chronic
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         Immunology
         Cell Biology
         Developmental Biology
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