We are analyzing https://link.springer.com/article/10.1186/s13287-018-0979-x.

Title:
Mesenchymal stem cells alleviate experimental autoimmune cholangitis through immunosuppression and cytoprotective function mediated by galectin-9 | Stem Cell Research & Therapy
Description:
Background Mesenchymal stem cells (MSCs) play an anti-inflammatory role by secreting certain bioactive molecules to exert their therapeutic effects for disease treatment. However, the underlying mechanism of MSCs in chronic autoimmune liver diseases—primary biliary cholangitis (PBC), for example—remains to be elucidated. Methods Human umbilical cord–derived MSCs (UC-MSCs) were injected intravenously into 2-octynoic acid coupled to bovine serum albumin (2OA-BSA)-induced autoimmune cholangitis mice. Serum levels of biomarkers and autoantibodies, histologic changes in the liver, diverse CD4+ T-cell subsets in different tissues, and chemokine activities were analyzed. Moreover, we investigated galectin-9 (Gal-9) expression and its function in UC-MSCs. Results In this study, UC-MSC transplantation (UC-MSCT) significantly ameliorated liver inflammation, primarily by diminishing T helper 1 (Th1) and Th17 responses as well as modifying liver chemokine activities in experimental autoimmune cholangitis mice. Mechanistically, UC-MSCs significantly repressed the proliferation of CD4+ T cells and suppressed the differentiation of Th1 and Th17 cells, which was likely dependent on Gal-9. Furthermore, the signal transducer and activator of transcription (STAT) and c-Jun N-terminal kinase (JNK) signaling pathways were involved in the production of Gal-9 in UC-MSCs. Conclusions These results suggest that Gal-9 contributes significantly to UC-MSC–mediated therapeutic effects and improve our understanding of the immunomodulatory mechanisms of MSCs in the treatment of PBC.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Science
Health & Fitness
Education

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,016 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

The income method remains a mystery to us.

Many websites are intended to earn money, but some serve to share ideas or build connections. Websites exist for all kinds of purposes. This might be one of them. Link.springer.com might be making money, but it's not detectable how they're doing it.

Keywords {🔍}

cells, ucmscs, article, gal, stem, cell, google, scholar, mesenchymal, cas, liver, cholangitis, expression, biliary, ucmsct, primary, pbc, umbilical, mice, galectin, ifnγ, autoimmune, cordderived, fig, serum, usa, mscs, stat, wang, blood, effects, study, transplantation, significantly, responses, sem, represent, data, zhang, treatment, jnk, bars, figure, chemokines, therapeutic, acid, proliferation, signaling, immunol, human,

Topics {✒️}

c-jun n-terminal kinase umbilical cord-derived msc 2oa-bsa–induced autoimmune cholangitis plv-cmv-gfp-neo vector p38/mitogen-activated protein kinase 20 ng/ml phorbol-12-myristate-13-acetate diverse cd4+ t-cell subsets bile duct damage hepatic mrna expression type-ii-interferon-mediated signalling suppress cd4+ t-cell proliferation combined cancer therapy disease-stage-based approach mesenchymal stem cells serum anti-pdc-e2 autoantibodies extracellular-regulated protein kinase cell stem cell 5 μg/ml anti-ifn-γ enzyme-linked immunosorbent assay induced autoimmune cholangitis suppress t-cell proliferation uc-msc–derived gal-9 primary biliary cholangitis double-positive yellow cells ifn-γ effectively activated including bone marrow /ml penicillin/streptomycin solution uc-msc conditioned media article download pdf lipoic acid-lysine located induce cross-species immunoreaction mesenchymal stromal cells umbilical cord beta-galactoside–binding proteins chemokine-chemokine receptor network 5 μg/ml anti-cd3 5 μg/ml anti-cd28 uc-msc–mediated therapeutic effects cd4+ t-cell proliferation ifn-γ–induced gal-9 expression 100 μg 2oa-bsa conjugate anti-pdc-e2 antibody conjugated anti-rabbit igg anti-pdc-e2 autoantibodies collagen-induced arthritis stem cell technologies exert anti-inflammatory actions mouse anti-gapdh antibody liver-infiltrating mononuclear cells interlobular bile ducts

Questions {❓}

Mesenchymal stem cell treatments in rheumatology: a glass half full?
Mesenchymal stromal cells and regulatory T cells: the yin and Yang of peripheral tolerance?
Pivotal role of paracrine effects in stem cell therapies in regenerative medicine: can we translate stem cell-secreted paracrine factors and microvesicles into better therapeutic strategies?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Mesenchymal stem cells alleviate experimental autoimmune cholangitis through immunosuppression and cytoprotective function mediated by galectin-9
         description:Mesenchymal stem cells (MSCs) play an anti-inflammatory role by secreting certain bioactive molecules to exert their therapeutic effects for disease treatment. However, the underlying mechanism of MSCs in chronic autoimmune liver diseases—primary biliary cholangitis (PBC), for example—remains to be elucidated. Human umbilical cord–derived MSCs (UC-MSCs) were injected intravenously into 2-octynoic acid coupled to bovine serum albumin (2OA-BSA)-induced autoimmune cholangitis mice. Serum levels of biomarkers and autoantibodies, histologic changes in the liver, diverse CD4+ T-cell subsets in different tissues, and chemokine activities were analyzed. Moreover, we investigated galectin-9 (Gal-9) expression and its function in UC-MSCs. In this study, UC-MSC transplantation (UC-MSCT) significantly ameliorated liver inflammation, primarily by diminishing T helper 1 (Th1) and Th17 responses as well as modifying liver chemokine activities in experimental autoimmune cholangitis mice. Mechanistically, UC-MSCs significantly repressed the proliferation of CD4+ T cells and suppressed the differentiation of Th1 and Th17 cells, which was likely dependent on Gal-9. Furthermore, the signal transducer and activator of transcription (STAT) and c-Jun N-terminal kinase (JNK) signaling pathways were involved in the production of Gal-9 in UC-MSCs. These results suggest that Gal-9 contributes significantly to UC-MSC–mediated therapeutic effects and improve our understanding of the immunomodulatory mechanisms of MSCs in the treatment of PBC.
         datePublished:2018-09-17T00:00:00Z
         dateModified:2018-09-17T00:00:00Z
         pageStart:1
         pageEnd:12
         license:http://creativecommons.org/publicdomain/zero/1.0/
         sameAs:https://doi.org/10.1186/s13287-018-0979-x
         keywords:
            Umbilical cord–derived mesenchymal stem cells
            Primary biliary cholangitis
            Galectin-9
            Inflammation
            Stem Cells
            Cell Biology
            Regenerative Medicine/Tissue Engineering
            Biomedical Engineering and Bioengineering
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13287-018-0979-x/MediaObjects/13287_2018_979_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13287-018-0979-x/MediaObjects/13287_2018_979_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13287-018-0979-x/MediaObjects/13287_2018_979_Fig3_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13287-018-0979-x/MediaObjects/13287_2018_979_Fig4_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13287-018-0979-x/MediaObjects/13287_2018_979_Fig5_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13287-018-0979-x/MediaObjects/13287_2018_979_Fig6_HTML.png
         isPartOf:
            name:Stem Cell Research & Therapy
            issn:
               1757-6512
            volumeNumber:9
            type:
               Periodical
               PublicationVolume
         publisher:
            name:BioMed Central
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Junyu Fan
               affiliation:
                     name:Nanjing University of Chinese Medicine
                     address:
                        name:Nanjing Drum Tower Hospital, Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Xiaojun Tang
               affiliation:
                     name:The Affiliated Drum Tower Hospital of Nanjing University Medical School
                     address:
                        name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Qian Wang
               affiliation:
                     name:The Affiliated Drum Tower Hospital of Nanjing University Medical School
                     address:
                        name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Zhuoya Zhang
               affiliation:
                     name:The Affiliated Drum Tower Hospital of Nanjing University Medical School
                     address:
                        name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Shufang Wu
               affiliation:
                     name:The Affiliated Drum Tower Hospital of Nanjing University Medical School
                     address:
                        name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Wenchao Li
               affiliation:
                     name:The Affiliated Drum Tower Hospital of Nanjing University Medical School
                     address:
                        name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Shanshan Liu
               affiliation:
                     name:The Affiliated Drum Tower Hospital of Nanjing University Medical School
                     address:
                        name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Genhong Yao
               affiliation:
                     name:The Affiliated Drum Tower Hospital of Nanjing University Medical School
                     address:
                        name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hongwei Chen
               affiliation:
                     name:The Affiliated Drum Tower Hospital of Nanjing University Medical School
                     address:
                        name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Lingyun Sun
               url:http://orcid.org/0000-0003-3392-0770
               affiliation:
                     name:Nanjing University of Chinese Medicine
                     address:
                        name:Nanjing Drum Tower Hospital, Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China
                        type:PostalAddress
                     type:Organization
                     name:The Affiliated Drum Tower Hospital of Nanjing University Medical School
                     address:
                        name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Mesenchymal stem cells alleviate experimental autoimmune cholangitis through immunosuppression and cytoprotective function mediated by galectin-9
      description:Mesenchymal stem cells (MSCs) play an anti-inflammatory role by secreting certain bioactive molecules to exert their therapeutic effects for disease treatment. However, the underlying mechanism of MSCs in chronic autoimmune liver diseases—primary biliary cholangitis (PBC), for example—remains to be elucidated. Human umbilical cord–derived MSCs (UC-MSCs) were injected intravenously into 2-octynoic acid coupled to bovine serum albumin (2OA-BSA)-induced autoimmune cholangitis mice. Serum levels of biomarkers and autoantibodies, histologic changes in the liver, diverse CD4+ T-cell subsets in different tissues, and chemokine activities were analyzed. Moreover, we investigated galectin-9 (Gal-9) expression and its function in UC-MSCs. In this study, UC-MSC transplantation (UC-MSCT) significantly ameliorated liver inflammation, primarily by diminishing T helper 1 (Th1) and Th17 responses as well as modifying liver chemokine activities in experimental autoimmune cholangitis mice. Mechanistically, UC-MSCs significantly repressed the proliferation of CD4+ T cells and suppressed the differentiation of Th1 and Th17 cells, which was likely dependent on Gal-9. Furthermore, the signal transducer and activator of transcription (STAT) and c-Jun N-terminal kinase (JNK) signaling pathways were involved in the production of Gal-9 in UC-MSCs. These results suggest that Gal-9 contributes significantly to UC-MSC–mediated therapeutic effects and improve our understanding of the immunomodulatory mechanisms of MSCs in the treatment of PBC.
      datePublished:2018-09-17T00:00:00Z
      dateModified:2018-09-17T00:00:00Z
      pageStart:1
      pageEnd:12
      license:http://creativecommons.org/publicdomain/zero/1.0/
      sameAs:https://doi.org/10.1186/s13287-018-0979-x
      keywords:
         Umbilical cord–derived mesenchymal stem cells
         Primary biliary cholangitis
         Galectin-9
         Inflammation
         Stem Cells
         Cell Biology
         Regenerative Medicine/Tissue Engineering
         Biomedical Engineering and Bioengineering
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13287-018-0979-x/MediaObjects/13287_2018_979_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13287-018-0979-x/MediaObjects/13287_2018_979_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13287-018-0979-x/MediaObjects/13287_2018_979_Fig3_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13287-018-0979-x/MediaObjects/13287_2018_979_Fig4_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13287-018-0979-x/MediaObjects/13287_2018_979_Fig5_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13287-018-0979-x/MediaObjects/13287_2018_979_Fig6_HTML.png
      isPartOf:
         name:Stem Cell Research & Therapy
         issn:
            1757-6512
         volumeNumber:9
         type:
            Periodical
            PublicationVolume
      publisher:
         name:BioMed Central
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Junyu Fan
            affiliation:
                  name:Nanjing University of Chinese Medicine
                  address:
                     name:Nanjing Drum Tower Hospital, Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xiaojun Tang
            affiliation:
                  name:The Affiliated Drum Tower Hospital of Nanjing University Medical School
                  address:
                     name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Qian Wang
            affiliation:
                  name:The Affiliated Drum Tower Hospital of Nanjing University Medical School
                  address:
                     name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Zhuoya Zhang
            affiliation:
                  name:The Affiliated Drum Tower Hospital of Nanjing University Medical School
                  address:
                     name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Shufang Wu
            affiliation:
                  name:The Affiliated Drum Tower Hospital of Nanjing University Medical School
                  address:
                     name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Wenchao Li
            affiliation:
                  name:The Affiliated Drum Tower Hospital of Nanjing University Medical School
                  address:
                     name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Shanshan Liu
            affiliation:
                  name:The Affiliated Drum Tower Hospital of Nanjing University Medical School
                  address:
                     name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Genhong Yao
            affiliation:
                  name:The Affiliated Drum Tower Hospital of Nanjing University Medical School
                  address:
                     name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hongwei Chen
            affiliation:
                  name:The Affiliated Drum Tower Hospital of Nanjing University Medical School
                  address:
                     name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Lingyun Sun
            url:http://orcid.org/0000-0003-3392-0770
            affiliation:
                  name:Nanjing University of Chinese Medicine
                  address:
                     name:Nanjing Drum Tower Hospital, Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China
                     type:PostalAddress
                  type:Organization
                  name:The Affiliated Drum Tower Hospital of Nanjing University Medical School
                  address:
                     name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Stem Cell Research & Therapy
      issn:
         1757-6512
      volumeNumber:9
Organization:
      name:BioMed Central
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Nanjing University of Chinese Medicine
      address:
         name:Nanjing Drum Tower Hospital, Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China
         type:PostalAddress
      name:The Affiliated Drum Tower Hospital of Nanjing University Medical School
      address:
         name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
         type:PostalAddress
      name:The Affiliated Drum Tower Hospital of Nanjing University Medical School
      address:
         name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
         type:PostalAddress
      name:The Affiliated Drum Tower Hospital of Nanjing University Medical School
      address:
         name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
         type:PostalAddress
      name:The Affiliated Drum Tower Hospital of Nanjing University Medical School
      address:
         name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
         type:PostalAddress
      name:The Affiliated Drum Tower Hospital of Nanjing University Medical School
      address:
         name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
         type:PostalAddress
      name:The Affiliated Drum Tower Hospital of Nanjing University Medical School
      address:
         name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
         type:PostalAddress
      name:The Affiliated Drum Tower Hospital of Nanjing University Medical School
      address:
         name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
         type:PostalAddress
      name:The Affiliated Drum Tower Hospital of Nanjing University Medical School
      address:
         name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
         type:PostalAddress
      name:Nanjing University of Chinese Medicine
      address:
         name:Nanjing Drum Tower Hospital, Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China
         type:PostalAddress
      name:The Affiliated Drum Tower Hospital of Nanjing University Medical School
      address:
         name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Junyu Fan
      affiliation:
            name:Nanjing University of Chinese Medicine
            address:
               name:Nanjing Drum Tower Hospital, Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China
               type:PostalAddress
            type:Organization
      name:Xiaojun Tang
      affiliation:
            name:The Affiliated Drum Tower Hospital of Nanjing University Medical School
            address:
               name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
               type:PostalAddress
            type:Organization
      name:Qian Wang
      affiliation:
            name:The Affiliated Drum Tower Hospital of Nanjing University Medical School
            address:
               name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
               type:PostalAddress
            type:Organization
      name:Zhuoya Zhang
      affiliation:
            name:The Affiliated Drum Tower Hospital of Nanjing University Medical School
            address:
               name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
               type:PostalAddress
            type:Organization
      name:Shufang Wu
      affiliation:
            name:The Affiliated Drum Tower Hospital of Nanjing University Medical School
            address:
               name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
               type:PostalAddress
            type:Organization
      name:Wenchao Li
      affiliation:
            name:The Affiliated Drum Tower Hospital of Nanjing University Medical School
            address:
               name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
               type:PostalAddress
            type:Organization
      name:Shanshan Liu
      affiliation:
            name:The Affiliated Drum Tower Hospital of Nanjing University Medical School
            address:
               name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
               type:PostalAddress
            type:Organization
      name:Genhong Yao
      affiliation:
            name:The Affiliated Drum Tower Hospital of Nanjing University Medical School
            address:
               name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
               type:PostalAddress
            type:Organization
      name:Hongwei Chen
      affiliation:
            name:The Affiliated Drum Tower Hospital of Nanjing University Medical School
            address:
               name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Lingyun Sun
      url:http://orcid.org/0000-0003-3392-0770
      affiliation:
            name:Nanjing University of Chinese Medicine
            address:
               name:Nanjing Drum Tower Hospital, Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China
               type:PostalAddress
            type:Organization
            name:The Affiliated Drum Tower Hospital of Nanjing University Medical School
            address:
               name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Nanjing Drum Tower Hospital, Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China
      name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
      name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
      name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
      name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
      name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
      name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
      name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
      name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
      name:Nanjing Drum Tower Hospital, Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China
      name:Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China

External Links {🔗}(160)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

5.2s.

LINK . SPRINGER . COM {}