
PMC . NCBI . NLM . NIH . GOV {
}
Title:
Genetic deletion of the mitochondrial phosphate carrier desensitizes the mitochondrial permeability transition pore and causes cardiomyopathy - PMC
Description:
The mitochondrial phosphate carrier (PiC) is critical for ATP synthesis by serving as the primary means for mitochondrial phosphate import across the inner membrane. In addition to its role in energy production, PiC is hypothesized to have a role in ...
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Keywords {🔍}
mitochondrial, doi, pic, mice, mptp, cardiac, atp, mitochondria, pubmed, google, scholar, figure, slca, deletion, protein, cell, heart, pmc, slcaflflmcm, weeks, hearts, death, article, phosphate, mefs, free, permeability, groups, cardiomyopathy, tamoxifen, swelling, function, measured, results, transition, synthesis, production, uptake, isolated, supplementary, gene, carrier, pore, component, loss, effect, versus, time, role, opening,
Topics {✒️}
α-myosin heavy-chain adenovirus-expressing cre recombinase sarcoplasmic reticulum wild type controls mitochondrial oxidative phosphorylation α-mhc-mcm mice homozygous slc25a3-loxp-targeted mice adenine nucleotide translocator tamoxifen-inducible cre recombinase oxidative phosphorylation fl/fl denotes slc25a3fl/fl slc25a3fl/fl-mcm mice displayed α-mhc promoter publisher site pdf reactive mitochondrial expansion inorganic phosphate slc25a3fl/fl-mcm mice compared mercremer α-mhc transgenic mice expressing mitochondrial phosphate-carrier deficiency tamoxifen-induced cre protein permeability transition pore slc25a3fl/fl mefs treated tamoxifen-inducible cre protein slc25a3fl/fl-mcm mice αmhc-mercermer myocyte cross-sectional areas slc25a3fl/fl-targeted mice slc25a3fl/fl-mcm model mitochondrial ros production pmc beta search control adenovirus tissue-specific gene manipulations crossing slc25a3fl/fl mice voltage-dependent anion channel ros production altered energy-linked ion movements embryonic stem cells mitochondrial permeability transition phosphate-free buffer reversible ca2+-induced permeabilization mitochondrial phosphate carrier short-term injury events mitochondrial permeability pore inducible cardiac-specific deletion direct pore-forming component reduced pi import/levels undergo permeability transition [32p] inhibitor-stop method
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