
PUBMED . NCBI . NLM . NIH . GOV {
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Title:
Genetic deletion of the mitochondrial phosphate carrier desensitizes the mitochondrial permeability transition pore and causes cardiomyopathy - PubMed
Description:
The mitochondrial phosphate carrier (PiC) is critical for ATP synthesis by serving as the primary means for mitochondrial phosphate import across the inner membrane. In addition to its role in energy production, PiC is hypothesized to have a role in cell death as either a component or a regulator of …
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Keywords {🔍}
mitochondrial, doi, permeability, transition, pmid, pmc, pubmed, epub, slca, free, cell, deletion, pore, article, states, pic, mptp, heart, calcium, nih, death, phosphate, gene, protein, figure, cardiol, metabolism, genetics, articles, mesh, aug, carrier, membrane, role, opening, review, transport, proteins, hhsunited, main, ncbi, full, text, abstract, similar, cited, references, information, grants, resources,
Topics {✒️}
united states government mitochondrial transport systems oxidative metabolism bcl-2 proteins mitochondrial permeability transition membrane mitochondrial phosphate carrier mitochondrial phosphate import affect permeability transition pubmed show main page content hhs mitochondrial cardiomyopathies funding linkout pic protein direct pore-forming component heart long-term resulted similar articles cited slc25a3 gene mice lacking slc25a3 intracellular calcium pools literature sources mitochondrial dna sequencing mitochondrial atp synthase genetic mitochondrial abnormalities mitochondrial-driven cardiomyopathy extramural research support cardiac-specific deletion articles references skladal calcium handling mitochondrial disorders mesh keyword mitochondrial disease ischaemia/reperfusion injury calcium heart serve heart disease overload induced death depressed cardiac function mouse model prevent mptp opening mptp opening due mol cell cardiol partially protected cells humans regulation minimum birth prevalence health curr opin cardiol inbred c57bl mitochondria
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