PUBMED . NCBI . NLM . NIH . GOV {
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Title:
Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice - PubMed
Description:
A critical event in ischemia-based cell death is the opening of the mitochondrial permeability transition pore (MPTP). However, the molecular identity of the components of the MPTP remains unknown. Here, we determined that the Bcl-2 family members Bax and Bak, which are central regulators of apoptot …
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Keywords {🔍}
cell, doi, mitochondrial, death, pmc, pmid, permeability, pubmed, figure, free, article, membrane, bax, review, pore, necrotic, transition, mptp, protein, outer, bcl, baxbak, ecollection, states, articles, elife, bak, karch, molkentin, regulated, mitochondria, necrosis, supplement, sci, research, nih, main, ncbi, figures, similar, cited, references, mesh, resources, aug, central, mouse, biol, apr, physiology,
Topics {✒️}
united states government funding linkout main page content cardiac-specific bax/bak1 deficiency… permeability transition pore anti-apoptotic bcl-2 family mitochondrial permeability transition mitochondrial permeability pore mitochondrial-dependent cell death bax/bak1 dko mefs voltage-dependent anion channels mice jason karch 1 cyclophilin d-overlapping pathways ischemia-based cell death bax channel-forming activity drug-induced liver injury outer membrane component bax/bak-deficient mitochondria membrane regulated process extramural research support hhs mitochondrial calcium overload resources elife articles references antonsson membrane mptp function bcl-2 necrotic cell death similar articles cited central regulators apoptotic cell death authors declare prevent cell death mediating cell death regulated cell death regulated necrosis drug-induced hepatotoxicity similar articles inhibition mouse molecular identity form apoptotic pores mitochondrial dynamics mitochondrial damage mitochondrial dysfunction sonia martinez-caballero prevents organelle rupture competing interests exist bh3 mimetics sensitize passive aggressive side blue light hazard ca2+ release channel
Questions {❓}
- Regulation of necrotic cell death: p53, PARP1 and cyclophilin D-overlapping pathways of regulated necrosis?
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