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Title:
Role of m6A writers, erasers and readers in cancer | Experimental Hematology & Oncology
Description:
The N(6)-methyladenosine (m6A) modification is the most pervasive modification of human RNAs. In recent years, an increasing number of studies have suggested that m6A likely plays important roles in cancers. Many studies have demonstrated that m6A is involved in the biological functions of cancer cells, such as proliferation, invasion, metastasis, and drug resistance. In addition, m6A is closely related to the prognosis of cancer patients. In this review, we highlight recent advances in understanding the function of m6A in various cancers. We emphasize the importance of m6A to cancer progression and look forward to describe future research directions.
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pubmed, cancer, google, scholar, article, cas, central, cell, mettl, promotes, progression, zhang, wang, mrna, rna, expression, cells, liu, carcinoma, chen, metastasis, proliferation, alkbh, yang, mol, fto, regulating, protein, igfbp, role, ythdf, res, nmethyladenosine, modification, signaling, lung, growth, inhibits, methylation, tumor, studies, resistance, pathway, invasion, breast, regulates, factor, methyltransferase, zhou, demethylase,
Topics {βοΈ}
mettl3-mir-25-3p-phlpp2-akt signaling axis /c-rel/il-8-mediated neutrophil infiltration pre-mir-181b-1/yap signaling axis aff4/nf-kappab/myc signaling network regulating lkb1/ampk/elavl1/lpact2 pathway n6-methyladenosine-dependent post-transcriptional modification pten-mediated pi3k/akt/mtor pathway fto-mediated mzf1/c-myc axis igf1-akt/s6 signaling pathway pi3k/akt/mtor signaling pathway pi3k/akt/mtor pathway mediated tgfb2/smad/mettl3 signaling axis mettl3-mediated n6-methyladenosine modification kdm4c-alkbh5-axl signaling axis fto-pgc-1alpha signalling axis mettl14-mediated n6-methyladenosine modification wtap-mediated n6-methyladenosine modification mir-193b-5p/mettl3 pathway ampkalpha2-fto-m6a/myc axis accelerating pri-microrna-221-3p maturation rna n6-methyladenosine methyltransferase activated wnt/beta-catenin signaling rna n6-methyladenosine methylation drives epithelial-mesenchymal transition n6-methyladenosine reader ythdc2 mir-204/igf2bp2/m6a-myc signaling mettl3/m6a/c-myc pathway pi3k/akt/mtor pathway [317] pi3k/akt/mtor pathway rna n6-methyladenosine modification jak/stat signalling pathway n6-methyladenosine mettl3 promotes transforming acidic coiled-coil n6-methyladenosine-mediated upregulation runx1-induced transcriptional activation m6a-hur-dependent epigenetic silencing fto-stabilized lncrna hoxc13 article download pdf zinc finger ccch-type zinc finger mym-type inhibiting mir-107/lats2-mediated activates pi3k/akt pathway inducing epithelial-mesenchymal transition cyld/nf-kappab pathway lncrna msc-as1 motivates excessive mir-25-3p maturation profile rna-protein interactions n6-methyladenosine-independent manner tata-box binding protein late endosomal/lysosomal adaptor
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headline:Role of m6A writers, erasers and readers in cancer
description:The N(6)-methyladenosine (m6A) modification is the most pervasive modification of human RNAs. In recent years, an increasing number of studies have suggested that m6A likely plays important roles in cancers. Many studies have demonstrated that m6A is involved in the biological functions of cancer cells, such as proliferation, invasion, metastasis, and drug resistance. In addition, m6A is closely related to the prognosis of cancer patients. In this review, we highlight recent advances in understanding the function of m6A in various cancers. We emphasize the importance of m6A to cancer progression and look forward to describe future research directions.
datePublished:2022-08-09T00:00:00Z
dateModified:2022-08-09T00:00:00Z
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Cancer
Writers
Erasers
Readers
Hematology
Oncology
Cancer Research
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headline:Role of m6A writers, erasers and readers in cancer
description:The N(6)-methyladenosine (m6A) modification is the most pervasive modification of human RNAs. In recent years, an increasing number of studies have suggested that m6A likely plays important roles in cancers. Many studies have demonstrated that m6A is involved in the biological functions of cancer cells, such as proliferation, invasion, metastasis, and drug resistance. In addition, m6A is closely related to the prognosis of cancer patients. In this review, we highlight recent advances in understanding the function of m6A in various cancers. We emphasize the importance of m6A to cancer progression and look forward to describe future research directions.
datePublished:2022-08-09T00:00:00Z
dateModified:2022-08-09T00:00:00Z
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N6-methyladenosine (m6A)
Cancer
Writers
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Hematology
Oncology
Cancer Research
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Analytics and Tracking {π}
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Libraries {π}
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