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LINK . SPRINGER . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
  10. External Links
  11. Analytics And Tracking
  12. Libraries
  13. CDN Services

We are analyzing https://link.springer.com/article/10.1186/s12943-024-02089-6.

Title:
Writers, readers, and erasers RNA modifications and drug resistance in cancer | Molecular Cancer
Description:
Drug resistance in cancer cells significantly diminishes treatment efficacy, leading to recurrence and metastasis. A critical factor contributing to this resistance is the epigenetic alteration of gene expression via RNA modifications, such as N6-methyladenosine (m6A), N1-methyladenosine (m1A), 5-methylcytosine (m5C), 7-methylguanosine (m7G), pseudouridine (Ψ), and adenosine-to-inosine (A-to-I) editing. These modifications are pivotal in regulating RNA splicing, translation, transport, degradation, and stability. Governed by “writers,” “readers,” and “erasers,” RNA modifications impact numerous biological processes and cancer progression, including cell proliferation, stemness, autophagy, invasion, and apoptosis. Aberrant RNA modifications can lead to drug resistance and adverse outcomes in various cancers. Thus, targeting RNA modification regulators offers a promising strategy for overcoming drug resistance and enhancing treatment efficacy. This review consolidates recent research on the role of prevalent RNA modifications in cancer drug resistance, with a focus on m6A, m1A, m5C, m7G, Ψ, and A-to-I editing. Additionally, it examines the regulatory mechanisms of RNA modifications linked to drug resistance in cancer and underscores the existing limitations in this field.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Science
  • Education
  • Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 7,642,828 visitors per month in the current month.

check SE Ranking
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How Does Link.springer.com Make Money? {💸}

We're unsure how the site profits.

Earning money isn't the goal of every website; some are designed to offer support or promote social causes. People have different reasons for creating websites. This might be one such reason. Link.springer.com might have a hidden revenue stream, but it's not something we can detect.

Keywords {🔍}

pubmed, article, google, scholar, cancer, cas, rna, resistance, central, cell, modifications, modification, wang, cells, drug, zhang, httpsdoiorgs, chen, mettl, mrna, liu, methylation, tumor, expression, mol, targeting, therapeutic, nmethyladenosine, editing, res, immune, promotes, role, rnas, protein, yang, nat, rev, sci, biol, signaling, huang, cancers, enhances, enhancing, dna, alkbh, zhao, therapy, fto,

Topics {✒️}

n6–methyladenosine upregulates mir–181d–5p exosomal mir-181d-5p derived tki targeting c-met/alk/ros1 hsa-linc02418/mmu-4930573i07rik regulated regulating mir-149-3p/s100a4/p53 axis raf/mek/erk signaling pathway crispr-cas-mediated genome editing trmt6/61a-dependent base methylation trim21-mediated pd-l1 ubiquitination y-box-binding protein ybx1 azgp1p2/uba1/rbm15 cascade mediates accelerating pri-microrna-221-3p maturation crispr/cas9-based epigenome editing anti-pd-l1 antibody atezolizumab m6a-mediated pd-1/pd-l1 linc00942–msi2–c-myc axis disrupt rig-i-mediated activation n6-adenosine-methyltransferase subunits mettl3 wnt/β-catenin signaling pathway pi3k/akt/mtor signaling pathway azgp1p2/uba1/rbm15/tpm1 cascade activating wnt/β-catenin pathway article download pdf cap-binding protein eif4e hsf4b/hsp90b1/mutant p53 axis aly/ref export factor azgp1p2/uba1/rbm15/tpm1 pathway promotes mir-146a expression crispr/cas enzymes suggests high c-met expression increased mir-221-3p expression plga-based nanoplatform loaded induce epithelial-mesenchymal transition lncrna-mediated posttranslational modifications synergistic chemo-photothermal therapy demethylase alkbh5-mediated upregulation castration-sensitive prostate cancer reduced ck2α-mediated glycolysis mettl1/wdr4-mediated trna mir-570-3p/spp1 axis intrinsic pro-tumorigenic genes post-transcriptionally regulating key elevated snhg17 facilitates n6-methyladenosine rna modification rna n6-methyladenosine modification rna modification n6-methyladenosine targeting epithelial-mesenchymal transition distinct n7-methylguanosine profiles proline-rich coiled-coil n6 methyladenosine-dependent mechanism

Questions {❓}

  • How the Warburg effect supports aggressiveness and drug resistance of cancer cells?

Schema {🗺️}

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         description:Drug resistance in cancer cells significantly diminishes treatment efficacy, leading to recurrence and metastasis. A critical factor contributing to this resistance is the epigenetic alteration of gene expression via RNA modifications, such as N6-methyladenosine (m6A), N1-methyladenosine (m1A), 5-methylcytosine (m5C), 7-methylguanosine (m7G), pseudouridine (Ψ), and adenosine-to-inosine (A-to-I) editing. These modifications are pivotal in regulating RNA splicing, translation, transport, degradation, and stability. Governed by “writers,” “readers,” and “erasers,” RNA modifications impact numerous biological processes and cancer progression, including cell proliferation, stemness, autophagy, invasion, and apoptosis. Aberrant RNA modifications can lead to drug resistance and adverse outcomes in various cancers. Thus, targeting RNA modification regulators offers a promising strategy for overcoming drug resistance and enhancing treatment efficacy. This review consolidates recent research on the role of prevalent RNA modifications in cancer drug resistance, with a focus on m6A, m1A, m5C, m7G, Ψ, and A-to-I editing. Additionally, it examines the regulatory mechanisms of RNA modifications linked to drug resistance in cancer and underscores the existing limitations in this field.
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      headline:Writers, readers, and erasers RNA modifications and drug resistance in cancer
      description:Drug resistance in cancer cells significantly diminishes treatment efficacy, leading to recurrence and metastasis. A critical factor contributing to this resistance is the epigenetic alteration of gene expression via RNA modifications, such as N6-methyladenosine (m6A), N1-methyladenosine (m1A), 5-methylcytosine (m5C), 7-methylguanosine (m7G), pseudouridine (Ψ), and adenosine-to-inosine (A-to-I) editing. These modifications are pivotal in regulating RNA splicing, translation, transport, degradation, and stability. Governed by “writers,” “readers,” and “erasers,” RNA modifications impact numerous biological processes and cancer progression, including cell proliferation, stemness, autophagy, invasion, and apoptosis. Aberrant RNA modifications can lead to drug resistance and adverse outcomes in various cancers. Thus, targeting RNA modification regulators offers a promising strategy for overcoming drug resistance and enhancing treatment efficacy. This review consolidates recent research on the role of prevalent RNA modifications in cancer drug resistance, with a focus on m6A, m1A, m5C, m7G, Ψ, and A-to-I editing. Additionally, it examines the regulatory mechanisms of RNA modifications linked to drug resistance in cancer and underscores the existing limitations in this field.
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         Cancer Research
         Oncology
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                     type:PostalAddress
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                  name:The First Affiliated Hospital of Zhengzhou University, Zhengzhou University
                  address:
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            name:Peng Gao
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                  name:The First Affiliated Hospital of Zhengzhou University, Zhengzhou University
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                  address:
                     name:Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
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            name:Dongming Yan
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                  name:The First Affiliated Hospital of Zhengzhou University, Zhengzhou University
                  address:
                     name:Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Shaohua Li
            affiliation:
                  name:The First Affiliated Hospital of Zhengzhou University, Zhengzhou University
                  address:
                     name:Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
                     type:PostalAddress
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            email:[email protected]
            type:Person
            name:Chen Xue
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                  name:The First Affiliated Hospital of Zhengzhou University, Zhengzhou University
                  address:
                     name:Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
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      name:Yeltai Nurzat
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      name:Lixia Xu
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      name:Lixin Wu
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            type:Organization
      name:Henan Jiao
      affiliation:
            name:The First Affiliated Hospital of Zhengzhou University, Zhengzhou University
            address:
               name:Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
               type:PostalAddress
            type:Organization
      name:Peng Gao
      affiliation:
            name:The First Affiliated Hospital of Zhengzhou University, Zhengzhou University
            address:
               name:Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
               type:PostalAddress
            type:Organization
      name:Xuqiang Zhu
      affiliation:
            name:The First Affiliated Hospital of Zhengzhou University, Zhengzhou University
            address:
               name:Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Dongming Yan
      affiliation:
            name:The First Affiliated Hospital of Zhengzhou University, Zhengzhou University
            address:
               name:Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Shaohua Li
      affiliation:
            name:The First Affiliated Hospital of Zhengzhou University, Zhengzhou University
            address:
               name:Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Chen Xue
      affiliation:
            name:The First Affiliated Hospital of Zhengzhou University, Zhengzhou University
            address:
               name:Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
      name:Department of Oncology, The First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and Technology, Luoyang, China
      name:State Key Laboratory of Respiratory Disease, Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
      name:Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
      name:Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
      name:Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
      name:Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
      name:Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
      name:Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
      name:Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
      name:Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
      name:Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China

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