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Keywords {🔍}

pubmed, article, google, scholar, cell, cancer, cas, central, rna, mettl, cells, apoptosis, autophagy, wang, mrna, methylation, death, protein, chen, fto, liu, nmethyladenosine, expression, zhang, mol, yang, pcd, progression, resistance, role, modification, translation, ythdf, ferroptosis, tumor, res, promotes, programmed, pyroptosis, necroptosis, proteins, alkbh, potential, methyltransferase, pathways, rnas, signaling, carcinoma, regulates, targeting,

Topics {✒️}

hypothermia-activated pi3k/akt/gsk-3β signaling pi3k/akt/gsk-3β signaling pathway photo-cross-linking-assisted m6a sequencing mir-25-3p/pten/akt signaling cascade daple/β-catenin/abcc9 signaling pathway aff4/nf-κb/myc signaling network augmented wnt/pi3k-akt signaling pre-mir-181b-1/yap signaling axis mrna-binding factor rbm15/spenito malat1-mir-1914-3p-yap axis low-level arsenic exposure m6a-hur-dependent epigenetic silencing β-catenin/abcc9 axis rna methylation-mediated repression post-transcriptional level recovered xct/gsh/gpx4 axis a-glut1-mtorc1 axis article download pdf rbm15/igf2bp3/tmbim6 axis nop2/sun domain family amp-activated protein kinase promoting rna-binding capability g1/s-phase arrest n6-methyladenine dna modification a-dependent epigenetic silencing atg7-cebpb signaling transmitted ifn-inducible transcription factor exhibits anti-leukemic activity n6-methyladenosine mettl3 promotes ischemia/reperfusion-induced pyroptosis combines antibody-based immunoprecipitation n6-methyladenine rna modification abundant rna-binding proteins m6a-mediated pcd axis hypoxia-induced hif-1α hif-1α-induced expression p62-selective autophagic degradation promotes cap-independent translation rna modification n6-methyladenosine zinc finger ccch-type accelerating pri-mir221/222 maturation lnc942 promoting mettl14-mediated maldi-tof-ms specific anti-m6a antibody excessive mir-25-3p maturation rna n6-methyladenosine methyltransferase npc drug-resistant cells bladder tumor-initiating cells m6a-governed pcd pathways photo-crosslinking-assisted

Questions {❓}

• With m6A engaged in the differentiation of embryonic stem cells (ESCs), sex determination, and spermatogenesis, what about those m6A modulators who are implicated in the differentiation of Leydig cells (LCs) and testosterone synthesis?

Schema {🗺️}

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      headline:Insights into N6-methyladenosine and programmed cell death in cancer
      description:N6-methyladenosine (m6A) methylation, the most common form of internal RNA modification in eukaryotes, has gained increasing attention and become a hot research topic in recent years. M6A plays multifunctional roles in normal and abnormal biological processes, and its role may vary greatly depending on the position of the m6A motif. Programmed cell death (PCD) includes apoptosis, autophagy, pyroptosis, necroptosis and ferroptosis, most of which involve the breakdown of the plasma membrane. Based on the implications of m6A methylation on PCD, the regulators and functional roles of m6A methylation were comprehensively studied and reported. In this review, we focus on the high-complexity links between m6A and different types of PCD pathways, which are then closely associated with the initiation, progression and resistance of cancer. Herein, clarifying the relationship between m6A and PCD is of great significance to provide novel strategies for cancer treatment, and has a great potential prospect of clinical application.
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         Cancer
         Apoptosis
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      name:The First Affiliated Hospital, Department of Rheumatology, Hengyang Medical School, University of South China, Hengyang, China
      name:The First Affiliated Hospital, Department of Rheumatology, Hengyang Medical School, University of South China, Hengyang, China
      name:The First Affiliated Hospital, Department of Hematology, Hengyang Medical School, University of South Chinal, Hengyang, China
      name:Department of Clinical Laboratory, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China
      name:Hunan Province Key Laboratory of Basic and Applied Hematology, Molecular Biology Research Center & Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, China
      name:Department of Clinical Laboratory, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China
      name:The First Affiliated Hospital, Department of Rheumatology, Hengyang Medical School, University of South China, Hengyang, China

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