
NCBI . NLM . NIH . GOV {
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Title[redir]:
Mechanism of RNA modification N6-methyladenosine in human cancer - PMC
Description:
Since the breakthrough discoveries of DNA and histone modifications, the field of RNA modifications has gained increasing interest in the scientific community. The discovery of N6-methyladenosine (m6A), a predominantly internal epigenetic ...
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Keywords {π}
doi, cancer, mettl, pubmed, google, scholar, pmc, article, free, cell, fto, cells, rna, zhang, expression, oncogene, promote, wang, mrna, proliferation, modification, ythdf, methylation, crc, chen, proteins, promotes, tumor, aml, metastasis, carcinoma, progression, alkbh, growth, overexpression, liu, invasion, hcc, translation, regulators, signaling, poor, yang, wtap, pathway, role, modifications, mol, alterations, development,
Topics {βοΈ}
modulates atp-p2rx6-ca2+-p-erk1/2-mmp9 signaling aff4/nf-kappab/myc signaling network n6-methyladenosine-dependent post-transcriptional modification p21/p27-dependent pattern mediated augmenting wnt/pi3k-akt signaling augmented wnt/pi3k-akt signaling ythdf2-dependent post-transcriptional silencing wnt/pi3k-akt signaling pathway mir-1246/spred2/mapk signaling pathway mrna-binding factor rbm15/spenito form wtap-wt1-tbl1 axis fto-pgc-1alpha signalling axis malat1-mir-1914-3p-yap axis targeting fto/ma/myc/cebpa signaling m6a-hur-dependent epigenetic silencing znf750-fgf14 signaling axis mettl3-ma-cdcp1 signaling axis refs mettl3/mettl14/ythdf1/ythdf2/fto/alkbh5 fak/pi3k/akt signaling mir-660/e2f3 axis-mediated inhibition post-transcriptional rna modification rna n6-methyladenosine methyltransferase rna n6-methyladenosine methyltransferase n6-methyladenosine rna mark rna modification n6-methyladenosine autosomal-recessive intellectual disability ythdf2-dependent posttranscriptional silencing wtapβwt1βtbl1 axis wtap-wt1-tbl1 axis generating mettl3-mettl14-wtap complex adam19/epha3/klf4 pathway [49] pi3k-akt-mtor pathway [107] pi3k/akt/mtor pathway n6-methyladenosine mettl3 promotes oncoprotein-encoding circular rna wnt/Ξ²-catenin pathway wnt/Ξ²-catenin pathway [66] cell-type-specific methylation patterns pmc beta search pi3k-akt-mtor pathways n6-methyladenosine-dependent regulation a-igf2bp2-dependent mechanism promotes cap-independent translation machinery component wtap/fl mettl3/mettl14/ythdf1/ythdf2/fto/alkbh5 activate mek/erk pathway supplementary information 12943_2020_1216_moesm1_esm excessive mir-25-3p maturation hematopoietic transcription factor zinc finger ccch-type
Questions {β}
- How does the methyltransferase family recognize their specific sites and modify them?
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