We are analyzing https://link.springer.com/article/10.1007/s10555-023-10126-x.

Title:
Resveratrol as sensitizer in colorectal cancer plasticity | Cancer and Metastasis Reviews
Description:
Abstract Despite tremendous medical treatment successes, colorectal cancer (CRC) remains a leading cause of cancer deaths worldwide. Chemotherapy as monotherapy can lead to significant side effects and chemoresistance that can be linked to several resistance-activating biological processes, including an increase in inflammation, cellular plasticity, multidrug resistance (MDR), inhibition of the sentinel gene p53, and apoptosis. As a consequence, tumor cells can escape the effectiveness of chemotherapeutic agents. This underscores the need for cross-target therapeutic approaches that are not only pharmacologically safe but also modulate multiple potent signaling pathways and sensitize cancer cells to overcome resistance to standard drugs. In recent years, scientists have been searching for natural compounds that can be used as chemosensitizers in addition to conventional medications for the synergistic treatment of CRC. Resveratrol, a natural polyphenolic phytoalexin found in various fruits and vegetables such as peanuts, berries, and red grapes, is one of the most effective natural chemopreventive agents. Abundant in vitro and in vivo studies have shown that resveratrol, in interaction with standard drugs, is an effective chemosensitizer for CRC cells to chemotherapeutic agents and thus prevents drug resistance by modulating multiple pathways, including transcription factors, epithelial-to-mesenchymal transition-plasticity, proliferation, metastasis, angiogenesis, cell cycle, and apoptosis. The ability of resveratrol to modify multiple subcellular pathways that may suppress cancer cell plasticity and reversal of chemoresistance are critical parameters for understanding its anti-cancer effects. In this review, we focus on the chemosensitizing properties of resveratrol in CRC and, thus, its potential importance as an additive to ongoing treatments. Graphical abstract
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Keywords {🔍}

pubmed, resveratrol, cancer, google, scholar, article, cas, cells, cell, crc, journal, central, resistance, colorectal, signaling, tumor, research, colon, expression, drug, effects, human, pathway, apoptosis, molecular, treatment, factor, clinical, mechanisms, wang, plasticity, activation, zhang, patients, international, pathways, cellular, growth, inhibition, stem, role, medicine, httpsdoiorgs, therapeutic, inflammation, nfκb, effect, metastasis, chemotherapeutic, drugs,

Topics {✒️}

tnf-α/nf-kb/inos/hif-1α axis-mediated fibrosis nuclear factor kappa-light-chain-enhancer il-1beta-induced nf-kappab-mediated inflammation regulating tlr4/syk/nf-κb signals tgf-β1/smads signaling pathway samson mathews samuel β1-integrin/hif-1α axis c-jun nh2-terminal kinase b-cell lymphoma extra-large pi3k/akt/nf-κb signaling pathway inhibits hypoxia-induced hif-1α inhibiting stat3/hif-1α/vegf pathway suppressing tlr4/nf-κb/stat3 activation copper-transporting p-type atpase interleukin-1β-induced chondrocytes injury inhibiting hif-1α/nlrp3 pathway s-phase cell-cycle arrest lipopolysaccharide-induced nf-κb activation il-1β-induced chondrocyte damage wnt/β-catenin signaling pathway altered cytokine profile grow human-monocyte-derived macrophages altered amino acid/protein/lipid regulating wnt/β-catenin signaling transcription factor nf-kappa sirt-1/nf-κb signaling pathway anti-inflammatory t-cell response sirt1-nf-κb signaling pathway /ampk/nf-kb pathway nf-κb-promoted end-proteins nuclear transcription factor-kappab inducing s-phase arrest inhibiting tlr4/hif-1α gly-ldl-induced huvecs titanium particle-induced osteolysis pyrene-induced colon polyps thioacetamide-induced liver injury pten-pi3k-akt axis tgf-beta increases induced wnt/β-catenin pathway cytokine-induced signaling pathways pro-apoptotic bax gene ameliorating p-glycoprotein activity pro-inflammatory-related activations basal pathogen-responsive sequence nf-κb inhibitor alpha downregulating hif-1α expression view keywords ‘cancer nf-κb signaling pathway

Questions {❓}

Are the cardioprotective effects of the phytoestrogen resveratrol sex-dependent?
Improving outcomes in colorectal cancer: Where do we go from here?
Oxidative stress, inflammation, and cancer: how are they linked?
Resveratrol supplementation: Where are we now and where should we go?
Resveratrol: A molecule whose time has come?
The legitimate inferential question is: Why has resveratrol been detected in many natural products?
What is new for an old molecule?

Schema {🗺️}

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      headline:Resveratrol as sensitizer in colorectal cancer plasticity
      description:Despite tremendous medical treatment successes, colorectal cancer (CRC) remains a leading cause of cancer deaths worldwide. Chemotherapy as monotherapy can lead to significant side effects and chemoresistance that can be linked to several resistance-activating biological processes, including an increase in inflammation, cellular plasticity, multidrug resistance (MDR), inhibition of the sentinel gene p53, and apoptosis. As a consequence, tumor cells can escape the effectiveness of chemotherapeutic agents. This underscores the need for cross-target therapeutic approaches that are not only pharmacologically safe but also modulate multiple potent signaling pathways and sensitize cancer cells to overcome resistance to standard drugs. In recent years, scientists have been searching for natural compounds that can be used as chemosensitizers in addition to conventional medications for the synergistic treatment of CRC. Resveratrol, a natural polyphenolic phytoalexin found in various fruits and vegetables such as peanuts, berries, and red grapes, is one of the most effective natural chemopreventive agents. Abundant in vitro and in vivo studies have shown that resveratrol, in interaction with standard drugs, is an effective chemosensitizer for CRC cells to chemotherapeutic agents and thus prevents drug resistance by modulating multiple pathways, including transcription factors, epithelial-to-mesenchymal transition-plasticity, proliferation, metastasis, angiogenesis, cell cycle, and apoptosis. The ability of resveratrol to modify multiple subcellular pathways that may suppress cancer cell plasticity and reversal of chemoresistance are critical parameters for understanding its anti-cancer effects. In this review, we focus on the chemosensitizing properties of resveratrol in CRC and, thus, its potential importance as an additive to ongoing treatments.
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         Chemoresistance
         Chemosensitization
         Multidrug resistance
         Resveratrol
         Cancer cell plasticity
         Cancer Research
         Oncology
         Biomedicine
         general
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      name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology (IIT) Guwahati, Guwahati, India
      name:Clinic of Gynecology and Obstetrics, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia
      name:Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar (Medbay), Education City, Qatar Foundation, Doha, Qatar
      name:Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia
      name:Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar (Medbay), Education City, Qatar Foundation, Doha, Qatar
      name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology (IIT) Guwahati, Guwahati, India
      name:Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich, Munich, Germany

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