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We began analyzing https://medscimonit.com/abstract/index/idArt/918369, but it redirected us to https://medscimonit.com/abstract/index/idArt/918369. The analysis below is for the second page.

Title[redir]:
Medical Science Monitor | Resveratrol Protects the Myocardium in Sepsis by Activating the Phosphatidylinositol 3-Kinases (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Pathway and Inhibiting the Nuclear Factor-κB (NF-κB) Signaling Pathway - Article abstract #918369
Description:
BACKGROUND:Sepsis combined with myocardial injury is an important cause of septic shock and multiple organ failure. However, the molecular mechanism of sepsis-induced myocardial dysfunction has not yet been thoroughly studied. Resveratrol has been an important research topic due its organ-protection function, but the specific mechanism is unclear. The purpose of this study was to explore the mechanism of organ injury in sepsis and to investigate the molecular mechanism of resveratrol in myocardial protection in sepsis. MATERIAL AND METHODS:A classical Sprague-Dawley rat model of sepsis peritonitis was constructed for further experiments. The PI3K inhibitor LY294002 and resveratrol were used to intervene in a rat model of cardiomyopathy. HE staining was used to observe pathological changes. Cardiomyocyte apoptosis was detected by TUNEL assay. Western blot analysis was used to detect the level of maker proteins. RESULTS:The PI3K inhibitors could promote cardiac abnormalities and apoptosis, but resveratrol showed the opposite effect. The upregulation function of the PI3K inhibitor on the expression of NF-κB, IL-6, IL-1β, and TLR4 in LPS rats was not obvious, but the expression of TNF-a in LPS+LY294002 rats was increased by 22.85% compared with that in LPS rats (P<0.05). Compared with the LPS group, the expression of NF-κB, TNF-α, IL-6, IL-1β, and TLR4 in the LPS+resveratrol group was decreased. The expression of p-PI3K, p-AKT, and p-mTOR in LPS+LY294002 was reduced. The expression p-PI3K, p-AKT, and p-mTOR in the myocardium of the LPS+resveratrol group was increased. CONCLUSIONS:Resveratrol can protect the myocardium in sepsis by activating the PI3K/AKT/mTOR signaling pathway and inhibiting the NF-κB signaling pathway and related inflammatory factors.

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🚄 Respectable Traffic: 10k - 20k visitors per month


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Keywords {🔍}

msm, med, sci, monit, doi, research, sepsis, review, information, resveratrol, article, analysis, editorial, press, expression, articles, clinical, pathway, nfκb, myocardial, injury, mechanism, related, international, medical, science, monitor, journals, myocardium, kinases, signaling, pik, lps, rats, group, share, email, database, women, privacy, cookies, scientific, reports, content, authors, animal, activating, phosphatidylinositol, inhibiting, nuclear,

Topics {✒️}

peer-reviewed scientific journal meta-analysis chatgpt provide patient-friendly pi3k/akt/mtor signaling pathway western blot analysis nf-κb signaling pathway related inflammatory factors sepsis-induced myocardial dysfunction categories editorial   editorial research analysis partners med sci monit links current volume nuclear factor-kappa /akt/mammalian target promote cardiac abnormalities androgenetic alopecia treatment cervical cancer screening auditory processing disorder sickle cell disease henoch-schönlein purpura nuclear factor-κb related disciplines information log phosphatidylinositol 3-kinases reliable information multiple organ failure international isi-science pi3k inhibitor ly294002 organ-protection function isi privacy policy lps+ly294002 rats lps+resveratrol group rat model authors journal' review expression p-pi3k social media pandemic preparedness retraction notes editorial   33 286 editorial organ injury p-akt nf-κb lps group lps+ly294002 pi3k inhibitor

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  • Can ChatGPT Provide Patient-Friendly and Reliable Information on Cervical Cancer Screening?

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