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We began analyzing https://link.springer.com/article/10.1007/s11684-021-0832-y, but it redirected us to https://link.springer.com/article/10.1007/s11684-021-0832-y. The analysis below is for the second page.

Title[redir]:
Resveratrol promotes the survival and neuronal differentiation of hypoxia-conditioned neuronal progenitor cells in rats with cerebral ischemia | Frontiers of Medicine
Description:
Hypoxia conditioning could increase the survival of transplanted neuronal progenitor cells (NPCs) in rats with cerebral ischemia but could also hinder neuronal differentiation partly by suppressing mitochondrial metabolism. In this work, the mitochondrial metabolism of hypoxia-conditioned NPCs (hcNPCs) was upregulated via the additional administration of resveratrol, an herbal compound, to resolve the limitation of hypoxia conditioning on neuronal differentiation. Resveratrol was first applied during the in vitro neuronal differentiation of hcNPCs and concurrently promoted the differentiation, synaptogenesis, and functional development of neurons derived from hcNPCs and restored the mitochondrial metabolism. Furthermore, this herbal compound was used as an adjuvant during hcNPC transplantation in a photothrombotic stroke rat model. Resveratrol promoted neuronal differentiation and increased the long-term survival of transplanted hcNPCs. 18-fluorine fluorodeoxyglucose positron emission tomography and rotarod test showed that resveratrol and hcNPC transplantation synergistically improved the neurological and metabolic recovery of stroke rats. In conclusion, resveratrol promoted the neuronal differentiation and therapeutic efficiency of hcNPCs in stroke rats via restoring mitochondrial metabolism. This work suggested a novel approach to promote the clinical translation of NPC transplantation therapy.

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Keywords {🔍}

pubmed, google, scholar, cas, cell, stem, cells, neuronal, resveratrol, central, differentiation, neural, stroke, zhang, mitochondrial, article, medicine, progenitor, cerebral, zhou, wang, liu, transplantation, brain, rats, metabolic, china, survival, yao, tian, hong, metabolism, med, university, research, rui, feng, rat, access, ischemic, privacy, cookies, content, ischemia, hypoxia, hcnpcs, vitro, injury, wei, zhejiang,

Topics {✒️}

month download article/chapter neural progenitor/stem cells neural progenitor fate wnt/β-catenin signalling hypoxia-inducible factor α neural progenitor cells oxygen sensing pathway oxygen-glucose deprivation/reoxygenation long-term resveratrol supplementation cell type-specific responses national key research neuronal stem cells neural stem cells mitochondrial energy metabolism central nervous system embryonic stem cells suppressing mitochondrial metabolism restoring mitochondrial metabolism moving stem cells full article pdf cerebral ischemic injury privacy choices/manage cookies undifferentiated cell state cerebral ischemia neuronal oxidative phosphorylation neurons derived hong zhang declare hypoxia-conditioned npcs vitro neuronal differentiation capital medical university stem cell biology stem cell niche stem cell characteristics check access trapping insulin receptor bennett jp jr nasr esfahani mh instant access health guangdong laboratory stem cell imaging vitro hypoxic preconditioning related subjects stem cell transplantation long-term window cell culture conditions ischemic rat brain medically relevant questions spinal cord injury niklison-chirou mv pet-ct center

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      name:Department of Nuclear Medicine and PET-CT Center, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China
      name:Beijing Laboratory for Cardiovascular Precision Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing, China
      name:Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China
      name:Department of Nuclear Medicine and PET-CT Center, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China
      name:Department of Nuclear Medicine and PET-CT Center, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China
      name:Key Laboratory for Biomedical Engineering of Ministry of Education, Zhejiang University, Hangzhou, China
      name:Shanxi Medical University, Taiyuan, China
      name:The College of Biomedical Engineering and Instrument Science of Zhejiang University, Hangzhou, China
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