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🌠 Phenomenal Traffic: 5M - 10M visitors per month


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Keywords {🔍}

sirt, resveratrol, cells, mscs, cell, chondrogenic, sirtaso, pubmed, google, scholar, doi, chondrocytes, sox, nfκb, differentiation, fig, culture, chondrogenesis, nam, cultures, msc, expression, alginate, ilβ, vitro, human, activation, cartilage, medium, high, stem, sirtso, density, control, pmc, shown, untreated, performed, signaling, bms, antibodies, primary, mesenchymal, protein, values, days, article, proteins, transcription, treatment,

Topics {✒️}

nf-κb-dependent pro-inflammatory enzymes nf-κb-dependent matrix-degrading enzymes regulated nf-κb-regulated pro-inflammatory peroxisome proliferator-activated receptor-γ β-glycerophosphate-induced endochondral mineralization nf-κb-dependent gene products nf-κb-regulated gene products blocks nf-κb-dependent transcription sirt1-aso-induced nf-κb phosphorylation suppressing nf-κb-mediated production de-acetylates nf-κb-p65 pro-inflammatory cytokine il-1β cartilage-specific extracellular matrix nf-κb transcription factor ikk-mediated nf-κb activation anti-phospho-specific iκbα antibodies nf-κb-dependent transcription nf-κb-inducing kinase nf-κb-dependent proinflammatory stem cell-specific markers nf-κb signaling pathways nf-κb signaling pathway resveratrol/sirt1-mediated signaling pathways wilcoxon-mann-whitney test inhibiting nf-κb pathway nf-κb-p65 subunit nf-κb subunit p65 full-thickness cartilage defects il-1β inhibited chondrogenesis-induced extensive cell-matrix interactions sirt1-aso-induced p65 acetylation nf-κb transcriptional activity cartilage-specific ecm components caused nf-κb activation de-acetylating nf-κb anti-phospho-specific p65 fitc-coupled secondary antibodies deficient shc-erk interaction anti-phospho-specific iκbα inhibited pro-inflammatory proteins pmc beta search inhibit nf-κb signaling specific antigen-antibody complexes age-related arthritic disease anti-phosphorylated nf-κb anti-cartilage specific proteoglycans cartilage-specific matrix expression p53 c-terminal domain inhibiting nf-κb activation organized extracellular matrix

Questions {❓}

• (1999) Articular cartilage repair: are the intrinsic biological constraints undermining this process insuperable?

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• Monthly income for https://doi.org/10.1006/cbir.1996.0119
• What's the revenue for https://scholar.google.com/scholar_lookup?journal=Cell%20Biol.%20Int&title=Differentiation%20of%20mesenchymal%20limb%20bud%20cells%20to%20chondrocytes%20in%20alginate%20beads&author=M.%20Shakibaei&author=P.%20De%20Souza&volume=21&publication_year=1997&pages=75-86&pmid=9080655&doi=10.1006/cbir.1996.0119&?
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• https://doi.org/10.1006/excr.1998.3933's total income per month
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• Get to know what's the income of https://scholar.google.com/scholar_lookup?journal=Arthritis%20Rheum&title=Sirtuin%201%20enzymatic%20activity%20is%20required%20for%20cartilage%20homeostasis%20in%20vivo%20in%20a%20mouse%20model&author=O.%20Gabay&author=C.%20Sanchez&author=M.%20Dvir-Ginzberg&author=V.%20Gagarina&author=K.%20J.%20Zaal&volume=65&publication_year=2013&pages=159-166&pmid=23124828&doi=10.1002/art.37750&
• How much revenue does https://doi.org/10.1016/j.jbspin.2013.01.001 generate?
• What are the total earnings of https://scholar.google.com/scholar_lookup?journal=Joint%20Bone%20Spine&title=SIRT1-deficient%20mice%20exhibit%20an%20altered%20cartilage%20phenotype&author=O.%20Gabay&author=K.%20J.%20Zaal&author=C.%20Sanchez&author=M.%20Dvir-Ginzberg&author=V.%20Gagarina&volume=80&publication_year=2013&pages=613-620&pmid=23587642&doi=10.1016/j.jbspin.2013.01.001&?
• Earnings of https://doi.org/10.1080/14653240600855905
• Financial intake of https://scholar.google.com/scholar_lookup?journal=Cytotherapy&title=Minimal%20criteria%20for%20defining%20multipotent%20mesenchymal%20stromal%20cells.%20The%20International%20Society%20for%20Cellular%20Therapy%20position%20statement&author=M.%20Dominici&author=K.%20Le%20Blanc&author=I.%20Mueller&author=I.%20Slaper-Cortenbach&author=F.%20Marini&volume=8&publication_year=2006&pages=315-317&pmid=16923606&doi=10.1080/14653240600855905&
• Discover the revenue of https://doi.org/10.1074/jbc.M112.355420
• How much cash flow does https://scholar.google.com/scholar_lookup?journal=J.%20Biol.%20Chem&title=SIRT1%20is%20required%20for%20the%20inhibition%20of%20apoptosis%20and%20inflammatory%20responses%20in%20human%20tenocytes&author=F.%20Busch&author=A.%20Mobasheri&author=P.%20Shayan&author=R.%20Stahlmann&author=M.%20Shakibaei&volume=287&publication_year=2012&pages=25770-25781&pmid=22689577&doi=10.1074/jbc.M112.355420& have monthly?
• https://doi.org/10.1006/cbir.1996.0118's total income per month
• Explore the financials of https://scholar.google.com/scholar_lookup?journal=Cell%20Biol.%20Int&title=Integrin%20expression%20and%20collagen%20type%20II%20implicated%20in%20maintenance%20of%20chondrocyte%20shape%20in%20monolayer%20culture:%20an%20immunomorphological%20study&author=M.%20Shakibaei&author=P.%20De%20Souza&author=H.%20J.%20Merker&volume=21&publication_year=1997&pages=115-125&pmid=9080658&doi=10.1006/cbir.1996.0118&
• How much does https://scholar.google.com/scholar_lookup?journal=Biochem.%20J&title=Signal%20transduction%20by%20%CE%B21%20integrin%20receptors%20in%20human%20chondrocytes%20in%20vitro:%20collaboration%20with%20the%20insulin-like%20growth%20factor-I%20receptor&author=M.%20Shakibaei&author=T.%20John&author=P.%20De%20Souza&author=R.%20Rahmanzadeh&author=H.%20J.%20Merker&volume=342&publication_year=1999&pages=615-623&pmid=10477272& generate monthly?
• How much does https://doi.org/10.1074/jbc.M010859200 pull in monthly?
• Monthly income for https://scholar.google.com/scholar_lookup?journal=J.%20Biol.%20Chem&title=Inhibition%20of%20mitogen-activated%20protein%20kinase%20kinase%20induces%20apoptosis%20of%20human%20chondrocytes&author=M.%20Shakibaei&author=G.%20Schulze-Tanzil&author=P.%20de%20Souza&author=T.%20John&author=M.%20Rahmanzadeh&volume=276&publication_year=2001&pages=13289-13294&pmid=11278768&doi=10.1074/jbc.M010859200&
• Check the income stats for https://doi.org/10.1016/j.bcp.2007.09.014
• What is the monthly revenue of https://scholar.google.com/scholar_lookup?journal=Biochem.%20Pharmacol&title=Regulation%20of%20inflammation%20signalling%20by%20resveratrol%20in%20human%20chondrocytes%20in%20vitro&author=C.%20Csaki&author=N.%20Keshishzadeh&author=K.%20Fischer&author=M.%20Shakibaei&volume=75&publication_year=2008&pages=677-687&pmid=17959154&doi=10.1016/j.bcp.2007.09.014&?
• What is the monthly revenue of https://doi.org/10.1074/jbc.M209677200?
• How profitable is https://scholar.google.com/scholar_lookup?journal=J.%20Biol.%20Chem&title=BMS-345541%20is%20a%20highly%20selective%20inhibitor%20of%20I%CE%BAB%20kinase%20that%20binds%20at%20an%20allosteric%20site%20of%20the%20enzyme%20and%20blocks%20NF-%CE%BAB-dependent%20transcription%20in%20mice&author=J.%20R.%20Burke&author=M.%20A.%20Pattoli&author=K.%20R.%20Gregor&author=P.%20J.%20Brassil&author=J.%20F.%20MacMaster&volume=278&publication_year=2003&pages=1450-1456&pmid=12403772&doi=10.1074/jbc.M209677200&?
• What is the earnings of https://doi.org/10.1371/journal.pone.0018447?
• What's the total monthly financial gain of https://scholar.google.com/scholar_lookup?journal=PLoS%20One&title=IKK%CE%B2%20regulates%20the%20repair%20of%20DNA%20double-strand%20breaks%20induced%20by%20ionizing%20radiation%20in%20MCF-7%20breast%20cancer%20cells&author=L.%20Wu&author=L.%20Shao&author=N.%20An&author=J.%20Wang&author=S.%20Pazhanisamy&volume=6&publication_year=2011&pages=e18447&pmid=21490922&doi=10.1371/journal.pone.0018447&?
• How much income does https://doi.org/10.1074/jbc.M209572200 have?
• What's the total monthly financial gain of https://scholar.google.com/scholar_lookup?journal=J.%20Biol.%20Chem&title=Post-activation%20turn-off%20of%20NF-%CE%BAB-dependent%20transcription%20is%20regulated%20by%20acetylation%20of%20p65&author=R.%20Kiernan&author=V.%20Br%C3%A8s&author=R.%20W.%20Ng&author=M.%20P.%20Coudart&author=S.%20El%20Messaoudi&volume=278&publication_year=2003&pages=2758-2766&pmid=12419806&doi=10.1074/jbc.M209572200&?
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• Find out how much https://scholar.google.com/scholar_lookup?journal=Proc.%20Natl.%20Acad.%20Sci.%20U.S.A&title=Tumor%20necrosis%20factor%20%CE%B1-induced%20phosphorylation%20of%20I%CE%BAB%CE%B1%20is%20a%20signal%20for%20its%20degradation%20but%20not%20dissociation%20from%20NF-%CE%BAB&author=S.%20Miyamoto&author=M.%20Maki&author=M.%20J.%20Schmitt&author=M.%20Hatanaka&author=I.%20M.%20Verma&volume=91&publication_year=1994&pages=12740-12744&pmid=7809113&doi=10.1073/pnas.91.26.12740& earns monthly
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• How much profit does https://scholar.google.com/scholar_lookup?journal=Nature&title=Small%20molecule%20activators%20of%20sirtuins%20extend%20Saccharomyces%20cerevisiae%20lifespan&author=K.%20T.%20Howitz&author=K.%20J.%20Bitterman&author=H.%20Y.%20Cohen&author=D.%20W.%20Lamming&author=S.%20Lavu&volume=425&publication_year=2003&pages=191-196&pmid=12939617&doi=10.1038/nature01960& make?
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• Revenue of https://doi.org/10.4049/jimmunol.164.12.6509
• What's https://scholar.google.com/scholar_lookup?journal=J.%20Immunol&title=Resveratrol%20suppresses%20TNF-induced%20activation%20of%20nuclear%20transcription%20factors%20NF-%CE%BAB,%20activator%20protein-1,%20and%20apoptosis:%20potential%20role%20of%20reactive%20oxygen%20intermediates%20and%20lipid%20peroxidation&author=S.%20K.%20Manna&author=A.%20Mukhopadhyay&author=B.%20B.%20Aggarwal&volume=164&publication_year=2000&pages=6509-6519&pmid=10843709&doi=10.4049/jimmunol.164.12.6509&'s gross income?
• What are the earnings of https://doi.org/10.1302/2046-3758.33.2000226?
• Earnings of https://scholar.google.com/scholar_lookup?journal=Bone%20Joint%20Res&title=The%20effect%20of%20resveratrol%20on%20normal%20and%20osteoarthritic%20chondrocyte%20metabolism&author=H.%20J.%20Kim&author=H.%20J.%20Braun&author=J.%20L.%20Dragoo&volume=3&publication_year=2014&pages=51-59&pmid=24615710&doi=10.1302/2046-3758.33.2000226&
• Financial intake of https://doi.org/10.1007/s10753-006-9012-0
• Explore the financials of https://scholar.google.com/scholar_lookup?journal=Inflammation&title=Effects%20of%20resveratrol%20in%20inflammatory%20arthritis&author=N.%20Elmali&author=O.%20Baysal&author=A.%20Harma&author=I.%20Esenkaya&author=B.%20Mizrak&volume=30&publication_year=2007&pages=1-6&pmid=17115116&doi=10.1007/s10753-006-9012-0&
• How much cash flow does https://doi.org/10.1146/annurev.biochem.74.082803.133500 have monthly?
• Profit of https://scholar.google.com/scholar_lookup?journal=Annu.%20Rev.%20Biochem&title=The%20biochemistry%20of%20sirtuins&author=A.%20A.%20Sauve&author=C.%20Wolberger&author=V.%20L.%20Schramm&author=J.%20D.%20Boeke&volume=75&publication_year=2006&pages=435-465&pmid=16756498&doi=10.1146/annurev.biochem.74.082803.133500&
• What's the profit of https://doi.org/10.1002/jbmr.460?
• Discover the revenue of https://scholar.google.com/scholar_lookup?journal=J.%20Bone%20Miner.%20Res&title=Resveratrol%20promotes%20osteogenesis%20of%20human%20mesenchymal%20stem%20cells%20by%20upregulating%20RUNX2%20gene%20expression%20via%20the%20SIRT1/FOXO3A%20axis&author=P.%20C.%20Tseng&author=S.%20M.%20Hou&author=R.%20J.%20Chen&author=H.%20W.%20Peng&author=C.%20F.%20Hsieh&volume=26&publication_year=2011&pages=2552-2563&pmid=21713995&doi=10.1002/jbmr.460&
• How much does https://doi.org/10.1016/j.bcp.2008.05.029 bring in each month?
• How much does https://scholar.google.com/scholar_lookup?journal=Biochem.%20Pharmacol&title=Resveratrol%20suppresses%20interleukin-1%CE%B2-induced%20inflammatory%20signaling%20and%20apoptosis%20in%20human%20articular%20chondrocytes:%20potential%20for%20use%20as%20a%20novel%20nutraceutical%20for%20the%20treatment%20of%20osteoarthritis&author=M.%20Shakibaei&author=C.%20Csaki&author=S.%20Nebrich&author=A.%20Mobasheri&volume=76&publication_year=2008&pages=1426-1439&pmid=18606398&doi=10.1016/j.bcp.2008.05.029& gross monthly?
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• What's the profit of https://scholar.google.com/scholar_lookup?journal=Genes%20Nutr&title=Curcumin%20synergizes%20with%20resveratrol%20to%20stimulate%20the%20MAPK%20signaling%20pathway%20in%20human%20articular%20chondrocytes%20in%20vitro&author=M.%20Shakibaei&author=A.%20Mobasheri&author=C.%20Buhrmann&volume=6&publication_year=2011&pages=171-179&pmid=21484156&doi=10.1007/s12263-010-0179-5&?
• https://doi.org/10.1182/blood-2002-11-3550's revenue stream
• How much does https://scholar.google.com/scholar_lookup?journal=Blood&title=Resveratrol%20blocks%20interleukin-1%CE%B2-induced%20activation%20of%20the%20nuclear%20transcription%20factor%20NF-%CE%BAB,%20inhibits%20proliferation,%20causes%20S-phase%20arrest,%20and%20induces%20apoptosis%20of%20acute%20myeloid%20leukemia%20cells&author=Z.%20Estrov&author=S.%20Shishodia&author=S.%20Faderl&author=D.%20Harris&author=Q.%20Van&volume=102&publication_year=2003&pages=987-995&pmid=12689943&doi=10.1182/blood-2002-11-3550& bring in each month?
• What's the income generated by https://doi.org/10.1111/j.1749-6632.2010.05852.x each month?
• Check the income stats for https://scholar.google.com/scholar_lookup?journal=Ann.%20N.Y.%20Acad.%20Sci&title=Chemosensitization%20of%20tumors%20by%20resveratrol&author=S.%20C.%20Gupta&author=R.%20Kannappan&author=S.%20Reuter&author=J.%20H.%20Kim&author=B.%20B.%20Aggarwal&volume=1215&publication_year=2011&pages=150-160&pmid=21261654&doi=10.1111/j.1749-6632.2010.05852.x&
• How much profit is https://doi.org/10.1126/stke.3572006re13 making per month?
• How much profit does https://scholar.google.com/scholar_lookup?journal=Sci.%20STKE&title=Regulation%20and%20function%20of%20IKK%20and%20IKK-related%20kinases&author=H.%20H%C3%A4cker&author=M.%20Karin&volume=2006&publication_year=2006&pages=re13&pmid=17047224&doi=10.1126/stke.3572006re13& generate?
• How much profit does https://doi.org/10.1371/journal.pone.0035712 generate?
• What's the monthly money flow for https://scholar.google.com/scholar_lookup?journal=PLoS%20One&title=Resveratrol-mediated%20modulation%20of%20SIRT1/Runx2%20promotes%20osteogenic%20differentiation%20of%20mesenchymal%20stem%20cells:%20potential%20role%20of%20Runx2%20deacetylation&author=M.%20Shakibaei&author=P.%20Shayan&author=F.%20Busch&author=C.%20Aldinger&author=C.%20Buhrmann&volume=7&publication_year=2012&pages=e35712&pmid=22539994&doi=10.1371/journal.pone.0035712&?
• Discover the revenue of https://doi.org/10.1016/s0092-8674(01)00527-x
• How much revenue does https://scholar.google.com/scholar_lookup?journal=Cell&title=hSIR2(SIRT1)%20functions%20as%20an%20NAD-dependent%20p53%20deacetylase&author=H.%20Vaziri&author=S.%20K.%20Dessain&author=E.%20Ng%20Eaton&author=S.%20I.%20Imai&author=R.%20A.%20Frye&volume=107&publication_year=2001&pages=149-159&pmid=11672523&doi=10.1016/s0092-8674(01)00527-x& produce monthly?
• What's the financial intake of https://doi.org/10.1038/sj.emboj.7600244?
• https://scholar.google.com/scholar_lookup?journal=EMBO%20J&title=Modulation%20of%20NF-%CE%BAB-dependent%20transcription%20and%20cell%20survival%20by%20the%20SIRT1%20deacetylase&author=F.%20Yeung&author=J.%20E.%20Hoberg&author=C.%20S.%20Ramsey&author=M.%20D.%20Keller&author=D.%20R.%20Jones&volume=23&publication_year=2004&pages=2369-2380&pmid=15152190&doi=10.1038/sj.emboj.7600244&'s financial summary
• Income figures for https://doi.org/10.1074/jbc.M803196200
• What's the monthly income of https://scholar.google.com/scholar_lookup?journal=J.%20Biol.%20Chem&title=Regulation%20of%20cartilage-specific%20gene%20expression%20in%20human%20chondrocytes%20by%20SIRT1%20and%20nicotinamide%20phosphoribosyltransferase&author=M.%20Dvir-Ginzberg&author=V.%20Gagarina&author=E.%20J.%20Lee&author=D.%20J.%20Hall&volume=283&publication_year=2008&pages=36300-36310&pmid=18957417&doi=10.1074/jbc.M803196200&?
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• Revenue of https://scholar.google.com/scholar_lookup?journal=Nature&title=Transcriptional%20silencing%20and%20longevity%20protein%20Sir2%20is%20an%20NAD-dependent%20histone%20deacetylase&author=S.%20Imai&author=C.%20M.%20Armstrong&author=M.%20Kaeberlein&author=L.%20Guarente&volume=403&publication_year=2000&pages=795-800&pmid=10693811&doi=10.1038/35001622&
• How profitable is https://doi.org/10.1002/emmm.201201606?
• How much revenue does https://scholar.google.com/scholar_lookup?journal=EMBO%20Mol.%20Med&title=SIRT1%20regulates%20differentiation%20of%20mesenchymal%20stem%20cells%20by%20deacetylating%20%CE%B2-catenin&author=P.%20Simic&author=K.%20Zainabadi&author=E.%20Bell&author=D.%20B.%20Sykes&author=B.%20Saez&volume=5&publication_year=2013&pages=430-440&pmid=23364955&doi=10.1002/emmm.201201606& generate?
• What is the earnings of https://doi.org/10.1074/jbc.M112.377028?
• What's the financial outcome of https://scholar.google.com/scholar_lookup?journal=J.%20Biol.%20Chem&title=Resveratrol%20modulates%20interleukin-1%CE%B2-induced%20phosphatidylinositol%203-kinase%20and%20nuclear%20factor%20%CE%BAB%20signaling%20pathways%20in%20human%20tenocytes&author=F.%20Busch&author=A.%20Mobasheri&author=P.%20Shayan&author=C.%20Lueders&author=R.%20Stahlmann&volume=287&publication_year=2012&pages=38050-38063&pmid=22936809&doi=10.1074/jbc.M112.377028&?
• What's the profit of https://doi.org/10.1359/jbmr.060415?
• How much does https://scholar.google.com/scholar_lookup?journal=J.%20Bone%20Miner.%20Res&title=Activation%20of%20SIRT1%20decreases%20adipocyte%20formation%20during%20osteoblast%20differentiation%20of%20mesenchymal%20stem%20cells&author=C.%20M.%20B%C3%A4ckesj%C3%B6&author=Y.%20Li&author=U.%20Lindgren&author=L.%20A.%20Haldos%C3%A9n&volume=21&publication_year=2006&pages=993-1002&pmid=16813520&doi=10.1359/jbmr.060415& bring in each month?
• https://github.com/ncbi's financial summary
• Monthly income for https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/%4038.9959508, -77.101021,17z/data%3D!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb%3A0x19156f88b27635b8!8m2!3d38.9959508! 4d-77.0988323
• How much revenue does https://www.nlm.nih.gov/web_policies.html generate?
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