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Keywords {🔍}

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Topics {✒️}

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Questions {❓}

• Are the cardioprotective effects of the phytoestrogen resveratrol sex-dependent?
• Improving outcomes in colorectal cancer: Where do we go from here?
• Oxidative stress, inflammation, and cancer: how are they linked?
• Resveratrol supplementation: Where are we now and where should we go?
• Resveratrol: A molecule whose time has come?
• The legitimate inferential question is: Why has resveratrol been detected in many natural products?
• What is new for an old molecule?

Schema {🗺️}

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         headline:Resveratrol as sensitizer in colorectal cancer plasticity
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      headline:Resveratrol as sensitizer in colorectal cancer plasticity
      description:Despite tremendous medical treatment successes, colorectal cancer (CRC) remains a leading cause of cancer deaths worldwide. Chemotherapy as monotherapy can lead to significant side effects and chemoresistance that can be linked to several resistance-activating biological processes, including an increase in inflammation, cellular plasticity, multidrug resistance (MDR), inhibition of the sentinel gene p53, and apoptosis. As a consequence, tumor cells can escape the effectiveness of chemotherapeutic agents. This underscores the need for cross-target therapeutic approaches that are not only pharmacologically safe but also modulate multiple potent signaling pathways and sensitize cancer cells to overcome resistance to standard drugs. In recent years, scientists have been searching for natural compounds that can be used as chemosensitizers in addition to conventional medications for the synergistic treatment of CRC. Resveratrol, a natural polyphenolic phytoalexin found in various fruits and vegetables such as peanuts, berries, and red grapes, is one of the most effective natural chemopreventive agents. Abundant in vitro and in vivo studies have shown that resveratrol, in interaction with standard drugs, is an effective chemosensitizer for CRC cells to chemotherapeutic agents and thus prevents drug resistance by modulating multiple pathways, including transcription factors, epithelial-to-mesenchymal transition-plasticity, proliferation, metastasis, angiogenesis, cell cycle, and apoptosis. The ability of resveratrol to modify multiple subcellular pathways that may suppress cancer cell plasticity and reversal of chemoresistance are critical parameters for understanding its anti-cancer effects. In this review, we focus on the chemosensitizing properties of resveratrol in CRC and, thus, its potential importance as an additive to ongoing treatments.
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         Colorectal cancer
         Chemoresistance
         Chemosensitization
         Multidrug resistance
         Resveratrol
         Cancer cell plasticity
         Cancer Research
         Oncology
         Biomedicine
         general
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      name:Clinic of Gynecology and Obstetrics, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia
      name:Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar (Medbay), Education City, Qatar Foundation, Doha, Qatar
      name:Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia
      name:Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar (Medbay), Education City, Qatar Foundation, Doha, Qatar
      name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology (IIT) Guwahati, Guwahati, India
      name:Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich, Munich, Germany

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