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Title:
Cyclin-dependent kinase 5 is an upstream regulator of mitochondrial fission during neuronal apoptosis - PubMed
Description:
Under physiological conditions, mitochondrial morphology dynamically shifts between a punctuate appearance and tubular networks. However, little is known about upstream signal transduction pathways that regulate mitochondrial morphology. We show that mitochondrial fission is a very early and kinetic …
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Keywords {🔍}
doi, pmid, mitochondrial, kinase, cyclindependent, neuronal, apoptosis, epub, cell, cdk, oct, fission, pmc, articles, song, review, lee, free, article, main, ncbi, similar, cited, mesh, resources, death, sjcdd, upstream, signal, transduction, small, pubmed, jun, drug, kim, inhibitors, metabolism, enzyme, bclx, protein, hhs, page, content, homepage, navigation, search, full, text, abstract, publication,
Topics {✒️}
cyclin-dependent kinase 5 main page content similar articles cited cdk5/drp1-mediated mitochondrial fragmentation upstream signalling kinase dominant-negative cdk5 mutant neurons mitochondria cdk5-mediated drp1 phosphorylation cdk5/p25 formation/inhibition drug news perspect hippocampal neuronal cells small interfering bcl cdk5-mediated neurotoxicity cell death differ neuronal cell death erk-mediated upregulation regulate mitochondrial morphology front cell neurosci united states government 4402087 abstract kinetically invariant event rnai knockdown experiments streptozotocin induces alzheimer' calcineurin regulates translocation 3pm-guided concept ndzie noah ml regulates mitochondrial fission martins de brito neuronal apoptosis cited mitochondrial medicine identified cdk5 mitochondrial fission cell biochem upstream regulator mol neurobiol weishaupt jh p25-p35 mitochondrial dysfunction hhs pubmed wordmark pubmed logo de pablo apoptosis official website physiological conditions punctuate appearance tubular networks causally contributes
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