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We began analyzing https://www.nature.com/articles/s41477-019-0419-7, but it redirected us to https://www.nature.com/articles/s41477-019-0419-7. The analysis below is for the second page.

Title[redir]:
A genetics screen highlights emerging roles for CPL3, RST1 and URT1 in RNA metabolism and silencing | Nature Plants
Description:
Post-transcriptional gene silencing (PTGS) is a major mechanism regulating gene expression in higher eukaryotes. To identify novel players in PTGS, a forward genetics screen was performed on an Arabidopsis thaliana line overexpressing a strong growth-repressive gene, ETHYLENE RESPONSE FACTOR6 (ERF6). We identified six independent ethyl-methanesulfonate mutants rescuing the dwarfism of ERF6-overexpressing plants as a result of transgene silencing. Among the causative genes, ETHYLENE-INSENSITIVE5, SUPERKILLER2 and HASTY1 have previously been reported to inhibit PTGS. Notably, the three other causative genes have not, to date, been related to PTGS: UTP:RNA-URIDYLYLTRANSFERASE1 (URT1), C-TERMINAL DOMAIN PHOSPHATASE-LIKE3 (CPL3) and RESURRECTION1 (RST1). We show that these genes may participate in protecting the 3’ end of transgene transcripts. We present a model in which URT1, CPL3 and RST1 are classified as PTGS suppressors, as compromisation of these genes provokes the accumulation of aberrant transcripts which, in turn, trigger the production of small interfering RNAs, initiating RNA silencing. A study uses a forward genetic screen to identify three new regulators (URT1, CPL3 and RST1) for post-transcriptional gene silencing (PTGS). These regulators may suppress PTGS by protecting the 3’ end of transgene transcripts.

Matching Content Categories {📚}

  • Education
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Content Management System {📝}

What CMS is doi.org built with?

Custom-built

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Traffic Estimate {📈}

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🌠 Phenomenal Traffic: 5M - 10M visitors per month


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Keywords {🔍}

pubmed, article, google, scholar, cas, central, arabidopsis, plant, rna, nature, cell, genes, plants, silencing, mrna, data, gene, access, genetics, thaliana, mol, development, nucleic, content, information, chen, dubois, acids, res, mirna, mrnas, cookies, analysis, rst, urt, inzé, ptgs, performed, functional, turnover, protein, required, degradation, vaucheret, ago, supplementary, privacy, function, processing, screen,

Topics {✒️}

nature portfolio journals permissions reprints nature portfolio privacy policy flanders research foundation c-terminal domain phosphatase-like3 advertising research stimulating scientific environment c-terminal domain phosphatase nature plants social media catalytic c-terminal domain protein fiery2/cpl1 interacts nature+ nature 431 nature transcriptional silencing induced strong growth-repressive gene cuticular wax biosynthesis rna-mediated gene silencing rna-binding proteins hyl1 mapk phosphorylation-induced stabilization chimeric gene-transposon transcripts sirna‐mediated chromatin silencing context-dependent dual role plant systems biology srna sequencing data rna quality control mrna sequencing data sirna-mediated ptgs defense université de bordeaux nonsense-mediated mrna decay forward genetics screen author correspondence nuclear quality control permissions institutional subscriptions read water-limiting conditions springerlink instant access cytoplasmic sgs3/rdr6‐bodies silenced post‐transcriptionally post-doctoral fellow fiery2/ctd phosphatase stress response pathway systems biology forwards genetics screen cytosolic rna exosome author cold stress responses

Schema {🗺️}

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      name:VIB Center for Plant Systems Biology, Ghent, Belgium
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      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(385)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Prism.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
  • zita.ns.cloudflare.com

CDN Services {📦}

  • Crossref

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