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DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
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  4. Monthly Traffic Estimate
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We began analyzing https://link.springer.com/article/10.1007/s10522-019-09816-3, but it redirected us to https://link.springer.com/article/10.1007/s10522-019-09816-3. The analysis below is for the second page.

Title[redir]:
Sexual dimorphism in rat thymic involution: a correlation with thymic oxidative status and inflammation | Biogerontology
Description:
The study investigated mechanisms underlying sex differences in thymic involution in Dark Agouti rats. Adverse effects of aging on thymus were more pronounced in males than in females. Thymi from old males exhibited more prominent: (i) fibro-adipose degeneration which correlated with greater intensity of thymic oxidative stress and enhanced thymic TGF-β and IL-6 expression and (ii) decline in thymopoiesis, as suggested by the number of the most mature CD4+CD8−/CD4−CD8+ single positive (SP) TCRαβhigh thymocytes. The greater accumulation of adipose tissue in old male thymus was linked with greater age-related increase in thymic expression of PPARγ and STAT3, a transcription factor regulating the expression of PPARγ downstream genes, in male than in female rats. In aged thymi of both sexes the early CD4−CD8− double negative (DN) stage of thymocyte development was affected, so relative accumulation of the least mature CD45RC+CD2− cells followed by decreased frequency of their DN and CD4+CD8+ double positive (DP) TCRαβ− descendants was observed. Additionally, in old males, because of the increased thymic expression of Nur77, a nuclear receptor involved in negative selection, and decreased CD90 (a negative regulator of thymocyte selection threshold) MFI on DP TCRαβint thymocytes, less efficient positive/more efficient negative selection was found. Moreover, in male rats, thymocyte post-selection differentiation/maturation was skewed towards CD4−CD8+ SP TCRαβhigh cells compared with age-matched females, reflecting, at least partly, greater IL-15 expression in their thymi. The study indicated mechanisms underlying sex-based differences in age-related thymic changes and consequently necessity of sex-specific approaches in designing strategies to rejuvenate thymus.

Matching Content Categories {📚}

  • Education
  • Science
  • Business & Finance

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🏙️ Massive Traffic: 50M - 100M visitors per month


Based on our best estimate, this website will receive around 80,486,609 visitors per month in the current month.

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How Does Doi.org Make Money? {💸}

We can't tell how the site generates income.

Not all websites are made for profit; some exist to inform or educate users. Or any other reason why people make websites. And this might be the case. Doi.org might be making money, but it's not detectable how they're doing it.

Keywords {🔍}

pubmed, article, google, scholar, cas, thymic, central, immunol, cell, thymocytes, thymus, aging, sex, cells, httpsdoiorg, cdcd, httpsdoiorgs, involution, expression, thymocyte, age, mice, differences, rats, growth, epithelial, oxidative, leposavić, selection, biol, rat, male, agerelated, female, negative, development, receptor, med, ageing, exp, function, status, pilipović, effects, stress, hormone, rev, role, sci, curr,

Topics {✒️}

tgf-β-induced epithelial-mesenchymal transition peroxisome-proliferator-activated receptor γ month download article/chapter article nacka-aleksić de la fuente pro/anti-inflammatory cytokines thymocyte post-selection differentiation/maturation post-selection intermediates leading tgf-β-mediated apoptosis enhanced thymic tgf-β fibro-adipose degeneration leukocyte-common antigen cd45 cd4/cd8/tcrαβ stained thymocytes transforming growth factor-β cd4−cd8+ single positive cd4+cd8+ double positive oxidant-induced lung injury transforming growth factor-βs starvation-induced lymphoid atrophy cd4+cd8+ thymocyte dfferentiation ghrelin-mediated signaling pathways bromobenzene-induced liver necrosis intriguing/neglected scenario paving interleukin-1-induced thymocyte proliferation mature cd45rc+cd2− cells growth hormone-mediated pathways thymus-hypothalamus/pituitary axis t-cell hybrid require generate cd4+cd8+ thymocytes recombinant-inbred mice maps tgf-beta signaling flow cytometry analyses glucocorticoid-treated rat thymocytes stress-induced thymic atrophy sex steroid-dependent plasticity il-15ra deficient mice pre-t-cell receptor cd4/cd8/ tcrαβ/annexin article biogerontology aims age-related thymic involution oxygen radical research full article pdf assess redox status jelena kotur-stevuljević kotur-stevuljević jelena nacka-aleksić greater age-related increase rat thymic involution human inkt cells increases thymic cellularity

Questions {❓}

  • Caruso C, Accardi G, Virruso C, Candore G (2013) Sex, gender and immunosenescence: a key to understand the different lifespan between men and women?
  • Tan J, Wang Y, Zhang N, Zhu X (2016) Induction of epithelial to mesenchymal transition (EMT) and inhibition on adipogenesis: two different sides of the same coin?

Schema {🗺️}

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         description:The study investigated mechanisms underlying sex differences in thymic involution in Dark Agouti rats. Adverse effects of aging on thymus were more pronounced in males than in females. Thymi from old males exhibited more prominent: (i) fibro-adipose degeneration which correlated with greater intensity of thymic oxidative stress and enhanced thymic TGF-β and IL-6 expression and (ii) decline in thymopoiesis, as suggested by the number of the most mature CD4+CD8−/CD4−CD8+ single positive (SP) TCRαβhigh thymocytes. The greater accumulation of adipose tissue in old male thymus was linked with greater age-related increase in thymic expression of PPARγ and STAT3, a transcription factor regulating the expression of PPARγ downstream genes, in male than in female rats. In aged thymi of both sexes the early CD4−CD8− double negative (DN) stage of thymocyte development was affected, so relative accumulation of the least mature CD45RC+CD2− cells followed by decreased frequency of their DN and CD4+CD8+ double positive (DP) TCRαβ− descendants was observed. Additionally, in old males, because of the increased thymic expression of Nur77, a nuclear receptor involved in negative selection, and decreased CD90 (a negative regulator of thymocyte selection threshold) MFI on DP TCRαβint thymocytes, less efficient positive/more efficient negative selection was found. Moreover, in male rats, thymocyte post-selection differentiation/maturation was skewed towards CD4−CD8+ SP TCRαβhigh cells compared with age-matched females, reflecting, at least partly, greater IL-15 expression in their thymi. The study indicated mechanisms underlying sex-based differences in age-related thymic changes and consequently necessity of sex-specific approaches in designing strategies to rejuvenate thymus.
         datePublished:2019-05-22T00:00:00Z
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      headline:Sexual dimorphism in rat thymic involution: a correlation with thymic oxidative status and inflammation
      description:The study investigated mechanisms underlying sex differences in thymic involution in Dark Agouti rats. Adverse effects of aging on thymus were more pronounced in males than in females. Thymi from old males exhibited more prominent: (i) fibro-adipose degeneration which correlated with greater intensity of thymic oxidative stress and enhanced thymic TGF-β and IL-6 expression and (ii) decline in thymopoiesis, as suggested by the number of the most mature CD4+CD8−/CD4−CD8+ single positive (SP) TCRαβhigh thymocytes. The greater accumulation of adipose tissue in old male thymus was linked with greater age-related increase in thymic expression of PPARγ and STAT3, a transcription factor regulating the expression of PPARγ downstream genes, in male than in female rats. In aged thymi of both sexes the early CD4−CD8− double negative (DN) stage of thymocyte development was affected, so relative accumulation of the least mature CD45RC+CD2− cells followed by decreased frequency of their DN and CD4+CD8+ double positive (DP) TCRαβ− descendants was observed. Additionally, in old males, because of the increased thymic expression of Nur77, a nuclear receptor involved in negative selection, and decreased CD90 (a negative regulator of thymocyte selection threshold) MFI on DP TCRαβint thymocytes, less efficient positive/more efficient negative selection was found. Moreover, in male rats, thymocyte post-selection differentiation/maturation was skewed towards CD4−CD8+ SP TCRαβhigh cells compared with age-matched females, reflecting, at least partly, greater IL-15 expression in their thymi. The study indicated mechanisms underlying sex-based differences in age-related thymic changes and consequently necessity of sex-specific approaches in designing strategies to rejuvenate thymus.
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