We are analyzing https://link.springer.com/article/10.1186/1742-4933-4-9.

Title:
Challenges for vaccination in the elderly | Immunity & Ageing
Description:
The increased susceptibility of the elderly to infection presents a major challenge to public health services. An aging immune system is well documented as the cause of increased infection rates in elderly people. Such immunosenescence is multi-factorial and incompletely understood. Immunosenescent changes include malfunctioning of innate immune system cellular receptors; involution of the thymus, with consequent reduction of the naïve T cell population; alteration of the T cell population composition; modified phenotypes of individual T cells; and replicative senescence of memory cells expressing naïve markers. Unfortunately, immunosenescence also renders vaccination less effective in the elderly. It is therefore important that the vaccines used against common but preventable diseases, such as influenza, are specifically enhanced to overcome the reduced immune responsiveness of this vulnerable population.
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

cells, elderly, article, google, scholar, pubmed, cell, immune, influenza, cas, response, vaccination, population, naïve, immunosenescence, age, system, vaccines, immunol, infection, vaccine, memory, function, figure, aging, thymic, decline, increased, innate, senescence, reduced, infections, expression, ageing, tlr, thymus, pathogens, receptor, senescent, production, authors, increase, protein, immunity, aspinall, effros, grubeckloebenstein, people, human, responses,

Topics {✒️}

hla-a2+ hiv-infected persons t-cell/b-cell interactions article download pdf west nile virus long-term hiv-specific cultures irreversible cell-cycle arrest mount pathogen-specific humoral giuseppe del giudice beatrix grubeck-loebenstein fluorescent-activated cell sorting telomere length measurements telomere length stabilization dysregulated pro-inflammatory cytokine cd8+ t-cell repertoire innate immune system adaptive immune system hiv-specific senescent cd8+ st/esa/ser privacy choices/manage cookies adaptive immune systems biomedical aging research cellular immune responses authors’ original file rapidly removes microorganisms immune system recognising epstein-barr virus surface markers cd45ra virus-specific cd8+ t-cell receptor public healthcare system innate immune response water emulsion mf59™ 2nd world assembly positively selected neonatal adaptive immune response mf59-adjuvanted vaccines human lymph nodes effective immune responses telomere length telomere erosion lead o'fallon wm aging immune system lancet infect dis hiv-specific cd8+ divergent telomerase patterns mech ageing dev t-cell memory full size image catalytic human telomerase author information authors

Questions {❓}

Akbar AN, Beverley PC, Salmon M: Will telomere erosion lead to a loss of T-cell memory?
Appay V, Rowland-Jones SL: Premature ageing of the immune system: the cause of AIDS?
Meyers DG: Could influenza vaccination prevent myocardial infarction, stroke and sudden cardiac death?
Pawelec G, Akbar A, Caruso C, Solana R, Grubeck-Loebenstein B, Wikby A: Human immunosenescence: is it infectious?
Pfister G, Weiskopf D, Lazuardi L, Kovaiou RD, Cioca DP, Keller M, Lorbeg B, Parson W, Grubeck-Loebenstein B: Naïve T cells in the elderly: are they still there?
Pfister G: Naïve or not Naïve?

Schema {🗺️}

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         headline:Challenges for vaccination in the elderly
         description:The increased susceptibility of the elderly to infection presents a major challenge to public health services. An aging immune system is well documented as the cause of increased infection rates in elderly people. Such immunosenescence is multi-factorial and incompletely understood. Immunosenescent changes include malfunctioning of innate immune system cellular receptors; involution of the thymus, with consequent reduction of the naïve T cell population; alteration of the T cell population composition; modified phenotypes of individual T cells; and replicative senescence of memory cells expressing naïve markers. Unfortunately, immunosenescence also renders vaccination less effective in the elderly. It is therefore important that the vaccines used against common but preventable diseases, such as influenza, are specifically enhanced to overcome the reduced immune responsiveness of this vulnerable population.
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      headline:Challenges for vaccination in the elderly
      description:The increased susceptibility of the elderly to infection presents a major challenge to public health services. An aging immune system is well documented as the cause of increased infection rates in elderly people. Such immunosenescence is multi-factorial and incompletely understood. Immunosenescent changes include malfunctioning of innate immune system cellular receptors; involution of the thymus, with consequent reduction of the naïve T cell population; alteration of the T cell population composition; modified phenotypes of individual T cells; and replicative senescence of memory cells expressing naïve markers. Unfortunately, immunosenescence also renders vaccination less effective in the elderly. It is therefore important that the vaccines used against common but preventable diseases, such as influenza, are specifically enhanced to overcome the reduced immune responsiveness of this vulnerable population.
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         Telomere Length
         West Nile Virus
         Innate Immune System
         Adaptive Immune System
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         Geriatrics/Gerontology
         Aging
         Public Health
         Clinical Nutrition
         Antibodies
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      name:Institute for Biomedical Aging Research, Austrian Academy of Sciences, Innsbruck, Austria
      name:Influenza Division, Centers for Disease Control and Prevention, Atlanta, USA

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