Here's how LINK.SPRINGER.COM makes money* and how much!

*Please read our disclaimer before using our estimates.
Loading...

LINK . SPRINGER . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
  10. External Links
  11. Analytics And Tracking
  12. Libraries
  13. CDN Services

We are analyzing https://link.springer.com/article/10.1007/s10522-017-9726-4.

Title:
Sex as a determinant of age-related changes in rat spinal cord inflammation-oxidation state | Biogerontology
Description:
To close the gap in our knowledge of sex influence on age-related changes in inflammation-oxidation state in spinal cord (SC) relevant to inflammation/oxidative-stress associated neuropathologies, 2–3 month-old (young) and 18–20 month-old (old) rats, exhibiting increased level of IL-6, a commonly used marker of inflamm-aging, were examined for inflammatory/redox status, and the underlying regulatory networks’ molecules expression. With age, rat SC microglia became sensitized (“primed”), while SC tissue shifted towards mild inflammatory state, with increased levels of proinflammatory IL-1β (key marker of microglial systemic inflammation-induced neurotoxicity), which was more prominent in males. This, most likely, reflected age- and sex-related impairment in the expression of CX3CR1, the receptor for fractalkine (CX3CL1), the soluble factor which regulates microglial activation and diminishes production of IL-1β (central for fractalkine neuroprotection). Considering that (i) age-related changes in SC IL-1β expression were not followed by complementary changes in SC IL-6 expression, and (ii) the reversal in the direction of the sex bias in circulating IL-6 level and SC IL-1β expression, it seems obvious that there are tissue-specific differences in the proinflammatory cytokine profile. Additionally, old male rat SC exhibited greater oxidative damage than female, reflecting, most likely, their lower capacity to maintain the pro-oxidant-antioxidant balance. In conclusion, these findings, apart from highlighting the significance of sex for age-associated changes in SC inflammation-oxidation, may be relevant for understating sex differences in human inflammation/oxidative-stress related SC diseases, and consequently, for optimizing their prevention/therapy.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Education
  • Health & Fitness
  • Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We don’t know how the website earns money.

Not every website is profit-driven; some are created to spread information or serve as an online presence. Websites can be made for many reasons. This could be one of them. Link.springer.com has a revenue plan, but it's either invisible or we haven't found it.

Keywords {🔍}

pubmed, article, google, scholar, cas, central, aging, oxidative, stress, brain, spinal, cord, microglia, microglial, doi, dois, sex, rat, expression, differences, med, belgrade, age, research, state, inflammatory, cxcr, fractalkine, role, function, agerelated, disease, mice, cell, aged, biol, biogerontology, leposavić, access, clin, res, inflammation, products, serbia, privacy, cookies, content, dimitrijević, rats, inflammaging,

Topics {✒️}

oxidant-induced lung injury month download article/chapter intriguing/neglected scenario paving guam parkinsonism-dementia complex pro-inflammatory cytokines released inflammation-oxidation state chronic-relapsing rat model pro-oxidant-antioxidant balance acute coronary syndrome oxidative protein-modification products bromobenzene-induced liver necrosis middle-aged rodent model spinal cord age-related neurodegenerative diseases central nervous system advanced oxidation products full article pdf article nacka-aleksić spinal motor neurons sc il-1β expression mild inflammatory state sc inflammation-oxidation jelena kotur-stevuljević zorica stojić-vukanić article biogerontology aims oxidation-inflammation theory age-related oxidative stress protein-dye binding privacy choices/manage cookies oxygen radical research rat sc microglia human liver disease older european subjects sc tissue shifted free radical homeostasis prooxidant-antioxidant balance rat immune system translational research cuprizone-induced demyelination nox2 gene expression gene-expression profile lower oxidative damage inflammation/oxidative-stress sc il-6 expression antioxidant vitamin administration total antioxidant capacity automated colorimetric method regulates microglial activation altered inflammatory profile hypothalamic mitochondrial bioenergetics

Questions {❓}

  • Salmon AB, Richardson A, Pérez VI (2010) Update on the oxidative stress theory of aging: does oxidative stress play a role in aging or healthy aging?
  • Which potential markers?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Sex as a determinant of age-related changes in rat spinal cord inflammation-oxidation state
         description:To close the gap in our knowledge of sex influence on age-related changes in inflammation-oxidation state in spinal cord (SC) relevant to inflammation/oxidative-stress associated neuropathologies, 2–3 month-old (young) and 18–20 month-old (old) rats, exhibiting increased level of IL-6, a commonly used marker of inflamm-aging, were examined for inflammatory/redox status, and the underlying regulatory networks’ molecules expression. With age, rat SC microglia became sensitized (“primed”), while SC tissue shifted towards mild inflammatory state, with increased levels of proinflammatory IL-1β (key marker of microglial systemic inflammation-induced neurotoxicity), which was more prominent in males. This, most likely, reflected age- and sex-related impairment in the expression of CX3CR1, the receptor for fractalkine (CX3CL1), the soluble factor which regulates microglial activation and diminishes production of IL-1β (central for fractalkine neuroprotection). Considering that (i) age-related changes in SC IL-1β expression were not followed by complementary changes in SC IL-6 expression, and (ii) the reversal in the direction of the sex bias in circulating IL-6 level and SC IL-1β expression, it seems obvious that there are tissue-specific differences in the proinflammatory cytokine profile. Additionally, old male rat SC exhibited greater oxidative damage than female, reflecting, most likely, their lower capacity to maintain the pro-oxidant-antioxidant balance. In conclusion, these findings, apart from highlighting the significance of sex for age-associated changes in SC inflammation-oxidation, may be relevant for understating sex differences in human inflammation/oxidative-stress related SC diseases, and consequently, for optimizing their prevention/therapy.
         datePublished:2017-08-19T00:00:00Z
         dateModified:2017-08-19T00:00:00Z
         pageStart:821
         pageEnd:839
         sameAs:https://doi.org/10.1007/s10522-017-9726-4
         keywords:
            Aging
            Spinal cord
            Inflammatory state
            Oxidation state
            CX3CR1
            Cell Biology
            Geriatrics/Gerontology
            Developmental Biology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10522-017-9726-4/MediaObjects/10522_2017_9726_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10522-017-9726-4/MediaObjects/10522_2017_9726_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10522-017-9726-4/MediaObjects/10522_2017_9726_Fig3_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10522-017-9726-4/MediaObjects/10522_2017_9726_Fig4_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10522-017-9726-4/MediaObjects/10522_2017_9726_Fig5_HTML.gif
         isPartOf:
            name:Biogerontology
            issn:
               1573-6768
               1389-5729
            volumeNumber:18
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer Netherlands
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Mirjana Nacka-Aleksić
               affiliation:
                     name:University of Belgrade
                     address:
                        name:Department of Physiology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Marija Stojanović
               affiliation:
                     name:University of Belgrade
                     address:
                        name:Department of Physiology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Lidija Simić
               affiliation:
                     name:University of Belgrade
                     address:
                        name:Department of Physiology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Biljana Bufan
               affiliation:
                     name:University of Belgrade
                     address:
                        name:Department of Microbiology and Immunology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jelena Kotur-Stevuljević
               affiliation:
                     name:University of Belgrade
                     address:
                        name:Department of Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Zorica Stojić-Vukanić
               affiliation:
                     name:University of Belgrade
                     address:
                        name:Department of Microbiology and Immunology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Mirjana Dimitrijević
               affiliation:
                     name:Institute for Biological Research “Siniša Stanković”, University of Belgrade
                     address:
                        name:Department of Immunology, Institute for Biological Research “Siniša Stanković”, University of Belgrade, Belgrade, Serbia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Slavica Ražić
               affiliation:
                     name:University of Belgrade
                     address:
                        name:Department of Analytical Chemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Gordana Leposavić
               affiliation:
                     name:University of Belgrade
                     address:
                        name:Department of Physiology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Sex as a determinant of age-related changes in rat spinal cord inflammation-oxidation state
      description:To close the gap in our knowledge of sex influence on age-related changes in inflammation-oxidation state in spinal cord (SC) relevant to inflammation/oxidative-stress associated neuropathologies, 2–3 month-old (young) and 18–20 month-old (old) rats, exhibiting increased level of IL-6, a commonly used marker of inflamm-aging, were examined for inflammatory/redox status, and the underlying regulatory networks’ molecules expression. With age, rat SC microglia became sensitized (“primed”), while SC tissue shifted towards mild inflammatory state, with increased levels of proinflammatory IL-1β (key marker of microglial systemic inflammation-induced neurotoxicity), which was more prominent in males. This, most likely, reflected age- and sex-related impairment in the expression of CX3CR1, the receptor for fractalkine (CX3CL1), the soluble factor which regulates microglial activation and diminishes production of IL-1β (central for fractalkine neuroprotection). Considering that (i) age-related changes in SC IL-1β expression were not followed by complementary changes in SC IL-6 expression, and (ii) the reversal in the direction of the sex bias in circulating IL-6 level and SC IL-1β expression, it seems obvious that there are tissue-specific differences in the proinflammatory cytokine profile. Additionally, old male rat SC exhibited greater oxidative damage than female, reflecting, most likely, their lower capacity to maintain the pro-oxidant-antioxidant balance. In conclusion, these findings, apart from highlighting the significance of sex for age-associated changes in SC inflammation-oxidation, may be relevant for understating sex differences in human inflammation/oxidative-stress related SC diseases, and consequently, for optimizing their prevention/therapy.
      datePublished:2017-08-19T00:00:00Z
      dateModified:2017-08-19T00:00:00Z
      pageStart:821
      pageEnd:839
      sameAs:https://doi.org/10.1007/s10522-017-9726-4
      keywords:
         Aging
         Spinal cord
         Inflammatory state
         Oxidation state
         CX3CR1
         Cell Biology
         Geriatrics/Gerontology
         Developmental Biology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10522-017-9726-4/MediaObjects/10522_2017_9726_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10522-017-9726-4/MediaObjects/10522_2017_9726_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10522-017-9726-4/MediaObjects/10522_2017_9726_Fig3_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10522-017-9726-4/MediaObjects/10522_2017_9726_Fig4_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10522-017-9726-4/MediaObjects/10522_2017_9726_Fig5_HTML.gif
      isPartOf:
         name:Biogerontology
         issn:
            1573-6768
            1389-5729
         volumeNumber:18
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Netherlands
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Mirjana Nacka-Aleksić
            affiliation:
                  name:University of Belgrade
                  address:
                     name:Department of Physiology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Marija Stojanović
            affiliation:
                  name:University of Belgrade
                  address:
                     name:Department of Physiology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Lidija Simić
            affiliation:
                  name:University of Belgrade
                  address:
                     name:Department of Physiology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Biljana Bufan
            affiliation:
                  name:University of Belgrade
                  address:
                     name:Department of Microbiology and Immunology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jelena Kotur-Stevuljević
            affiliation:
                  name:University of Belgrade
                  address:
                     name:Department of Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Zorica Stojić-Vukanić
            affiliation:
                  name:University of Belgrade
                  address:
                     name:Department of Microbiology and Immunology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Mirjana Dimitrijević
            affiliation:
                  name:Institute for Biological Research “Siniša Stanković”, University of Belgrade
                  address:
                     name:Department of Immunology, Institute for Biological Research “Siniša Stanković”, University of Belgrade, Belgrade, Serbia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Slavica Ražić
            affiliation:
                  name:University of Belgrade
                  address:
                     name:Department of Analytical Chemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Gordana Leposavić
            affiliation:
                  name:University of Belgrade
                  address:
                     name:Department of Physiology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Biogerontology
      issn:
         1573-6768
         1389-5729
      volumeNumber:18
Organization:
      name:Springer Netherlands
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Belgrade
      address:
         name:Department of Physiology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
         type:PostalAddress
      name:University of Belgrade
      address:
         name:Department of Physiology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
         type:PostalAddress
      name:University of Belgrade
      address:
         name:Department of Physiology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
         type:PostalAddress
      name:University of Belgrade
      address:
         name:Department of Microbiology and Immunology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
         type:PostalAddress
      name:University of Belgrade
      address:
         name:Department of Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
         type:PostalAddress
      name:University of Belgrade
      address:
         name:Department of Microbiology and Immunology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
         type:PostalAddress
      name:Institute for Biological Research “Siniša Stanković”, University of Belgrade
      address:
         name:Department of Immunology, Institute for Biological Research “Siniša Stanković”, University of Belgrade, Belgrade, Serbia
         type:PostalAddress
      name:University of Belgrade
      address:
         name:Department of Analytical Chemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
         type:PostalAddress
      name:University of Belgrade
      address:
         name:Department of Physiology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Mirjana Nacka-Aleksić
      affiliation:
            name:University of Belgrade
            address:
               name:Department of Physiology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
               type:PostalAddress
            type:Organization
      name:Marija Stojanović
      affiliation:
            name:University of Belgrade
            address:
               name:Department of Physiology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
               type:PostalAddress
            type:Organization
      name:Lidija Simić
      affiliation:
            name:University of Belgrade
            address:
               name:Department of Physiology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
               type:PostalAddress
            type:Organization
      name:Biljana Bufan
      affiliation:
            name:University of Belgrade
            address:
               name:Department of Microbiology and Immunology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
               type:PostalAddress
            type:Organization
      name:Jelena Kotur-Stevuljević
      affiliation:
            name:University of Belgrade
            address:
               name:Department of Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
               type:PostalAddress
            type:Organization
      name:Zorica Stojić-Vukanić
      affiliation:
            name:University of Belgrade
            address:
               name:Department of Microbiology and Immunology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
               type:PostalAddress
            type:Organization
      name:Mirjana Dimitrijević
      affiliation:
            name:Institute for Biological Research “Siniša Stanković”, University of Belgrade
            address:
               name:Department of Immunology, Institute for Biological Research “Siniša Stanković”, University of Belgrade, Belgrade, Serbia
               type:PostalAddress
            type:Organization
      name:Slavica Ražić
      affiliation:
            name:University of Belgrade
            address:
               name:Department of Analytical Chemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
               type:PostalAddress
            type:Organization
      name:Gordana Leposavić
      affiliation:
            name:University of Belgrade
            address:
               name:Department of Physiology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Physiology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
      name:Department of Physiology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
      name:Department of Physiology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
      name:Department of Microbiology and Immunology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
      name:Department of Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
      name:Department of Microbiology and Immunology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
      name:Department of Immunology, Institute for Biological Research “Siniša Stanković”, University of Belgrade, Belgrade, Serbia
      name:Department of Analytical Chemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
      name:Department of Physiology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(378)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Clipboard.js
  • Prism.js

CDN Services {📦}

  • Crossref

4.45s.