We are analyzing https://link.springer.com/article/10.1007/s00109-004-0608-2.

Title:
Tolerance, suppression and the fetal allograft | Journal of Molecular Medicine
Description:
In solid organ transplantation the recipient immune system recognises foreign alloantigens expressed by the graft. This results in an immune attack of the transplanted organ leading to rejection, which can be prevented only by therapeutic immunosuppression. During pregnancy the fetus should also be rejected by the maternal immune system, since it expresses antigens derived from the father. Whilst the immune system retains the ability to respond to foreign antigen, tolerance mechanisms ensure that inappropriate responses against self-antigen are prevented. Maternal immune aggression directed against the fetus is partly inhibited by peripheral tolerance mechanisms that act locally to deplete cells capable of attacking the fetus. Other local mechanisms inhibit the pathways that cause tissue damage after immune activation. Recent studies in mice and humans indicate that the maternal immune system undergoes a more systemic change that promotes materno-fetal tolerance. Naturally occurring regulatory T cells, which are commonly associated with maintaining tolerance to self-antigens, can also suppress maternal allo-responses targeted against the fetus. We review the mechanisms that mediate materno-fetal tolerance, with particular emphasis on changes in regulatory T cell function during pregnancy and discuss their implications.
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Keywords {🔍}

google, scholar, cas, pubmed, article, cells, immunol, med, exp, tolerance, regulatory, immune, cell, nat, suppressor, tcell, factor, pregnancy, suppression, system, maternal, antigen, mice, cdcd, immunity, nature, response, rev, science, autoimmune, sakaguchi, antibody, function, fetal, mechanisms, activation, regulation, molecular, aluvihare, fetus, human, immunology, lymphocytes, histocompatibility, antigenspecific, privacy, cookies, content, journal, innate,

Topics {✒️}

month download article/chapter suppressive t-cell factor promotes materno-fetal tolerance t-cell antigen receptor monoclonal anti-np tsf3 t-cell repertoire diversity hybrid t-cell line mediate materno-fetal tolerance require trance-rank signals hapten-conjugated syngeneic structures distinct t-cell subclasses t-cell-dependent suppression receptor-driven regulatory mechanisms janeway ca jr toll pathway-dependent blockade high dose tolerance-absence plaque-forming cell responses solid organ transplantation hapten-specific antibody response post-thymectomy autoimmune oophoritis maternal immune system human immune system cell-driven complement activation full article pdf t-cell subclasses beta-chain genes pathogenic cell-mediated immunity multiple organ pathology immune system retains innate immune system maternal genome specific t-cell subsets privacy choices/manage cookies early maternal tolerance fetal allograft peripheral tolerance mechanisms medical research council transplanted organ leading leukemia inhibitory factor innate immune recognition t-cell homeostasis conventional anti-picryl complement alternative pathway allogeneic fetal rejection soluble factors released immune response region major histocompatibility complex homocytotropic antibody formation ox-22low subset antigen-specific inhibitory

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         description:In solid organ transplantation the recipient immune system recognises foreign alloantigens expressed by the graft. This results in an immune attack of the transplanted organ leading to rejection, which can be prevented only by therapeutic immunosuppression. During pregnancy the fetus should also be rejected by the maternal immune system, since it expresses antigens derived from the father. Whilst the immune system retains the ability to respond to foreign antigen, tolerance mechanisms ensure that inappropriate responses against self-antigen are prevented. Maternal immune aggression directed against the fetus is partly inhibited by peripheral tolerance mechanisms that act locally to deplete cells capable of attacking the fetus. Other local mechanisms inhibit the pathways that cause tissue damage after immune activation. Recent studies in mice and humans indicate that the maternal immune system undergoes a more systemic change that promotes materno-fetal tolerance. Naturally occurring regulatory T cells, which are commonly associated with maintaining tolerance to self-antigens, can also suppress maternal allo-responses targeted against the fetus. We review the mechanisms that mediate materno-fetal tolerance, with particular emphasis on changes in regulatory T cell function during pregnancy and discuss their implications.
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      headline:Tolerance, suppression and the fetal allograft
      description:In solid organ transplantation the recipient immune system recognises foreign alloantigens expressed by the graft. This results in an immune attack of the transplanted organ leading to rejection, which can be prevented only by therapeutic immunosuppression. During pregnancy the fetus should also be rejected by the maternal immune system, since it expresses antigens derived from the father. Whilst the immune system retains the ability to respond to foreign antigen, tolerance mechanisms ensure that inappropriate responses against self-antigen are prevented. Maternal immune aggression directed against the fetus is partly inhibited by peripheral tolerance mechanisms that act locally to deplete cells capable of attacking the fetus. Other local mechanisms inhibit the pathways that cause tissue damage after immune activation. Recent studies in mice and humans indicate that the maternal immune system undergoes a more systemic change that promotes materno-fetal tolerance. Naturally occurring regulatory T cells, which are commonly associated with maintaining tolerance to self-antigens, can also suppress maternal allo-responses targeted against the fetus. We review the mechanisms that mediate materno-fetal tolerance, with particular emphasis on changes in regulatory T cell function during pregnancy and discuss their implications.
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