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         headline:Normal thymus in adults: appearance on CT and associations with age, sex, BMI and smoking
         description:To investigate CT appearance and size of the thymus in association with participant characteristics. 2540 supposedly healthy participants (mean age 58.9 years, 51 % female) were evaluated for the CT appearance of thymic glands with four-point scores (according to the ratio of fat and soft tissue), size and morphology. These were correlated with participants’ age, sex, BMI and smoking history. Of 2540 participants, 1869 (74 %) showed complete fatty replacement of the thymus (Score 0), 463 (18 %) predominantly fatty attenuation (Score 1), 172 (7 %) half fatty and half soft-tissue attenuation (Score 2) and 36 (1 %) solid thymic gland with predominantly soft-tissue attenuation (Score 3). Female participants showed less fatty degeneration of the thymus with higher thymic scores within age 40–69 years (P < 0.001). Participants with lower thymic scores showed higher BMI (P < 0.001) and were more likely to be former smokers (P < 0.001) with higher pack-years (P = 0.04). Visual assessment with four-point thymic scores revealed a sex difference in the fatty degeneration of the thymus with age. Women show significantly higher thymic scores, suggesting less fat content of the thymus, during age 40–69 years. Cigarette smoking and high BMI are associated with advanced fatty replacement of the thymus. • 74 % of participants (mean age 58.9 years) demonstrated complete fatty thymus. • Women show less fatty thymus compared to men at ages 40–69 years. • Smoking and high BMI are associated with advanced fatty degeneration in thymus.
         datePublished:2015-04-30T00:00:00Z
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      headline:Normal thymus in adults: appearance on CT and associations with age, sex, BMI and smoking
      description:To investigate CT appearance and size of the thymus in association with participant characteristics. 2540 supposedly healthy participants (mean age 58.9 years, 51 % female) were evaluated for the CT appearance of thymic glands with four-point scores (according to the ratio of fat and soft tissue), size and morphology. These were correlated with participants’ age, sex, BMI and smoking history. Of 2540 participants, 1869 (74 %) showed complete fatty replacement of the thymus (Score 0), 463 (18 %) predominantly fatty attenuation (Score 1), 172 (7 %) half fatty and half soft-tissue attenuation (Score 2) and 36 (1 %) solid thymic gland with predominantly soft-tissue attenuation (Score 3). Female participants showed less fatty degeneration of the thymus with higher thymic scores within age 40–69 years (P < 0.001). Participants with lower thymic scores showed higher BMI (P < 0.001) and were more likely to be former smokers (P < 0.001) with higher pack-years (P = 0.04). Visual assessment with four-point thymic scores revealed a sex difference in the fatty degeneration of the thymus with age. Women show significantly higher thymic scores, suggesting less fat content of the thymus, during age 40–69 years. Cigarette smoking and high BMI are associated with advanced fatty replacement of the thymus. • 74 % of participants (mean age 58.9 years) demonstrated complete fatty thymus. • Women show less fatty thymus compared to men at ages 40–69 years. • Smoking and high BMI are associated with advanced fatty degeneration in thymus.
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         Thymus gland
         Adult
         Body mass index
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         Neuroradiology
         Ultrasound
         Internal Medicine
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