
DOI . ORG {
}
Title[redir]:
Overview of Mammary Gland Development: A Comparison of Mouse and Human | SpringerLink
Description:
The mouse mammary gland is widely used as a model for human breast cancer and has greatly added to our understanding of the molecular mechanisms involved in breast cancer development and progression. To fully appreciate the validity and limitations of the mouse...
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Keywords {π}
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Topics {βοΈ}
transforming growth factor-beta1 month download article/chapter p-cadherin-deficient mice long-term rodent studies elicit ductal side-branching age-related lobular involution progesterone induces side-branching mammary epithelial growth stat3-induced apoptosis requires transcription factor activities silberstein gb programmed cell death autocrine prolactin induced prolactin-induced morphogenesis epithelial progesterone receptor mammary gland neoplasia multiple hormone interactions privacy choices/manage cookies device instant download apoptotic epithelial cells wagner ku apoptotic cell death editor information editors luminal cell fate ferreira-cornwell mc murine mammary gland mammary gland development mammary-gland development human mammary gland epithelial cell death mammary epithelial hierarchy mammary gland morphogenesis o'malley bw mouse mammary gland mammary gland involution mammary branching morphogenesis schwertfeger kl daniel cw hovey rc genomic signature induced ucd conway institute early hyperplastic precursors fgf10/fgfr2b signaling rankl signaling axis mammary fat pad mammary growth mouse mammary epithelium mammary gland initiation early embryonic phase abdominal mammary glands
Questions {β}
- Couse JF, Korach KS (1999) Estrogen receptor null mice: what have we learned and where will they lead us?
- LaMarca HL, Rosen JM (2008) Minireview: hormones and mammary cell fate β what will I become when I grow up?
Schema {πΊοΈ}
ScholarlyArticle:
headline:Overview of Mammary Gland Development: A Comparison of Mouse and Human
pageEnd:17
pageStart:1
image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4939-6475-8.jpg
genre:
Springer Protocols
isPartOf:
name:Mammary Gland Development
isbn:
978-1-4939-6475-8
978-1-4939-6473-4
type:Book
publisher:
name:Springer New York
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Sara McNally
affiliation:
name:University College Dublin
address:
name:UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin, Ireland
type:PostalAddress
type:Organization
email:[email protected]
type:Person
name:Torsten Stein
affiliation:
name:University of Glasgow
address:
name:Institute of Cancer Sciences, College of MVLS, University of Glasgow, Glasgow, UK
type:PostalAddress
type:Organization
type:Person
keywords:Mammary gland, Breast, Development, Morphogenesis
description:The mouse mammary gland is widely used as a model for human breast cancer and has greatly added to our understanding of the molecular mechanisms involved in breast cancer development and progression. To fully appreciate the validity and limitations of the mouse model, it is essential to be aware of the similarities and also the differences that exist between the mouse mammary gland and the human breast. This introduction therefore describes the parallels and contrasts in mouse mammary gland and human breast morphogenesis from an early embryonic phase through to puberty, adulthood, pregnancy, parturition, and lactation, and finally the regressive stage of involution.
datePublished:2017
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