We are analyzing https://link.springer.com/article/10.1186/bcr754.

Title:
Gene expression profiling of mammary gland development reveals putative roles for death receptors and immune mediators in post-lactational regression | Breast Cancer Research
Description:
Introduction In order to gain a better understanding of the molecular processes that underlie apoptosis and tissue regression in mammary gland, we undertook a large-scale analysis of transcriptional changes during the mouse mammary pregnancy cycle, with emphasis on the transition from lactation to involution. Method Affymetrix microarrays, representing 8618 genes, were used to compare mammary tissue from 12 time points (one virgin, three gestation, three lactation and five involution stages). Six animals were used for each time point. Common patterns of gene expression across all time points were identified and related to biological function. Results The majority of significantly induced genes in involution were also differentially regulated at earlier stages in the pregnancy cycle. This included a marked increase in inflammatory mediators during involution and at parturition, which correlated with leukaemia inhibitory factor–Stat3 (signal transducer and activator of signalling-3) signalling. Before involution, expected increases in cell proliferation, biosynthesis and metabolism-related genes were observed. During involution, the first 24 hours after weaning was characterized by a transient increase in expression of components of the death receptor pathways of apoptosis, inflammatory cytokines and acute phase response genes. After 24 hours, regulators of intrinsic apoptosis were induced in conjunction with markers of phagocyte activity, matrix proteases, suppressors of neutrophils and soluble components of specific and innate immunity. Conclusion We provide a resource of mouse mammary gene expression data for download or online analysis. Here we highlight the sequential induction of distinct apoptosis pathways in involution and the stimulation of immunomodulatory signals, which probably suppress the potentially damaging effects of a cellular inflammatory response while maintaining an appropriate antimicrobial and phagocytic environment.
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Keywords {🔍}

expression, involution, mammary, genes, pubmed, gland, gene, google, scholar, cas, article, time, apoptosis, cell, clusters, transcripts, fig, cells, expressed, table, lactation, hours, analysis, data, death, cluster, inv, development, phase, immune, pregnancy, increase, stat, cycle, mouse, induced, profiles, factors, role, central, receptor, acute, function, tissue, point, differentially, protein, number, points, response,

Topics {✒️}

tumor necrosis factor-alpha tnfalpha induces nfkappab/p50 caat-enhancer binding protein breast cancer research acute-phase mediators lif–stat3 acute-phase response gene full size image leukaemia inhibitory factor–stat3 localized acute-phase response gene expression profiling profiling gene expression induces nf-κb signalling anti-inflammatory effects vital immune cell-mediated killing clear dead/dying cells putative anti-inflammatory role monocyte/macrophage markers lrp jennifer lee & tom freeman nf-kappab inhibits apoptosis stat3-mediated cell death acute phase protein stromelysin-1 regulates adipogenesis igf-binding protein 5 breast cancer res monocyte/macrophage markers lrp1 breast cancer cells single-cell transcript analysis error bars represent d'cruz cm privacy choices/manage cookies acute phase response acute-phase response dna binding activity post-lactational regression proinflammatory mediators il-1a protein encoding capacity authors’ original file mammary organogenesis reveals protein encoding content acute phase proteins anti-inflammatory factors adult mammary gland acute phase signalling acute phase genes gene ontology consortium article number r92 paape mj exhibit altered activity anti-inflammatory response lps binding protein

Questions {❓}

Monks J, Geske FJ, Lehman L, Fadok VA: Do inflammatory cells participate in mammary gland involution?
Transcriptional regulation of apoptosis in involution: two phases of death?

Schema {🗺️}

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