We are analyzing https://link.springer.com/article/10.1186/bcr1740.

Title:
Estrogen regulation of mammary gland development and breast cancer: amphiregulin takes center stage | Breast Cancer Research
Description:
Estrogen-mediated proliferation is fundamental to normal mammary gland development. Recent studies have demonstrated that amphiregulin is a critical paracrine regulator of estrogen action during ductal morphogenesis. These studies implicate a critical role for amphiregulin in mammary stem cell differentiation as well as breast cancer initiation and progression.
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Keywords {🔍}

mammary, cells, breast, cancer, areg, stem, pubmed, ductal, cell, article, estrogen, paracrine, receptor, growth, proliferation, egfr, gland, factor, google, scholar, cas, morphogenesis, development, studies, epithelial, amphiregulin, epidermal, adam, erαpositive, brisken, factors, role, central, activity, erαnegative, progression, signaling, colleagues, phenotype, coworkers, epithelium, expression, privacy, cookies, research, recent, demonstrated, critical, differentiation, mice,

Topics {✒️}

proteasome-dependent egfr de-ubiquitination stem/progenitor cell activity epidermal growth factor erα-negative stem cells er-negative stem cells erα-positive progenitor cells stem/progenitor cell population renewing lin-cd29hicd24+ cell estrogen receptor-positive tumors hormone-dependent breast cancer hormone-dependent breast cancers erα-null mammary glands resulting erα-positive cell asselin-labat ml stem cell activity adjacent er-negative cells transforming growth factor mammary stem cell erα-null mammary epithelium areg-null epithelial cells areg-null mammary glands single stem cell mammary stem cells stem/progenitor cells adam17-dependent autocrine loop cell growth differ regulate hormone-induced proliferation cell tissue res mammary gland development stem cell biology estrogen-mediated paracrine events key paracrine factor human breast cancer human breast tumors adjacent erα-negative targeting adam17 activity estrogen-induced ductal morphogenesis puberal mammary gland functional mammary gland growth factor mammary ductal development mammary gland morphogenesis local growth factors exclusively erα-negative natl cancer inst privacy choices/manage cookies wt epithelial cells secrete paracrine factors breast cancer res basal population revealed

Questions {❓}

First, is AREG necessary and sufficient to rescue ductal morphogenesis in ERα-null mammary epithelium, or are other paracrine factors involved?
Second, how does AREG signal through the basement membrane and the myoepithelium to act on EGFR in the stroma?
These studies raise the following critical question: how can a single ERα-negative stem cell give rise to a complete, functional ductal tree when transplanted into the cleared mammary fat pad?
This postulate raises the following critical question: what is the mechanism(s) by which estrogens induce ductal epithelial proliferation?
What implications do these studies of normal mammary ductal morphogenesis have for our understanding of human breast cancer?
What insights do these studies provide with respect to the potential role of estrogen-mediated proliferation in mammary stem cells?

Schema {🗺️}

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         description:Estrogen-mediated proliferation is fundamental to normal mammary gland development. Recent studies have demonstrated that amphiregulin is a critical paracrine regulator of estrogen action during ductal morphogenesis. These studies implicate a critical role for amphiregulin in mammary stem cell differentiation as well as breast cancer initiation and progression.
         datePublished:2007-07-20T00:00:00Z
         dateModified:2007-07-20T00:00:00Z
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            Mammary Gland Development
            Paracrine Factor
            Mammary Stem Cell
            Stem Cell Activity
            Cancer Research
            Oncology
            Surgical Oncology
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         Surgical Oncology
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