
NCBI . NLM . NIH . GOV {
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Title[redir]:
Determinants of resistance to VEGF-TKI and immune checkpoint inhibitors in metastatic renal cell carcinoma - PMC
Description:
Vascular endothelial growth factor tyrosine kinase inhibitors (VEGF-TKIs) have been the mainstay of treatment for patients with advanced renal cell carcinoma (RCC). Despite its early promising results in decreasing or delaying the progression of RCC ...
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doi, cell, pubmed, rcc, cells, google, scholar, cancer, patients, pmc, article, renal, free, tumour, carcinoma, resistance, sunitinib, treatment, nct, immune, expression, therapy, hypoxia, metastatic, trial, phase, pfs, survival, combination, tumours, clinical, oncol, progression, study, inhibitors, response, endothelial, checkpoint, hifα, iii, tumor, risk, clin, mrcc, antiangiogenic, advanced, studies, months, shown, safety,
Topics {✒️}
pyruvate dehydrogenase kinase von hippel-lindau disease von hippel-lindau syndrome von hippel-lindau glucose transporter-1 matrix metalloproteinases akt/gsk-3β/β-catenin signaling pathway hypoxia-inducible factor-1-dependent repression transporter proteins bone marrow-derived cells cd25+cd127+foxp3/helios+ gitr+tregs phenotype pdk hexokinase programmed death-ligand 1 /programmed death-ligand 1 mammalian target g-protein-coupled receptor 41 tumor necrosis factor glucocorticoid-induced tnf receptor chromophobe rcc bone-marrow microenvironment ret/papillary thyroid carcinomas hypoxia-inducible factor tyrosine kinase inhibitors g-protein-coupled adenosine receptors increase glucose uptake mesenchymal-epithelial transition factor myeloid-derived suppressor cells diacylglycerol protein kinase tumour protein p53 bruton tyrosine kinase chrcc egfr tyrosine kinase inhibitor il-1β/hif-2α/notch1 signals cell immunoglobulin mucin mi-rna profiling study previously received pd-1/pd-l1mab hypoxia-mediated hif1-α activation phosphatidylinositol 3-kinase/akt pathway marciscano ae serine/threonine kinase involved antagonizing p53-mediated apoptosis glucose metabolism multi-target vegf-tki metastatic renal-cell carcinoma pd-l1-positive tumour patients akt/mtor signalling pathway encodes vhl protein glut1
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- Can we translate non-inferiority clinical trial into practice?
- Current cancer situation in China: good or bad news from the 2018 Global Cancer Statistics?
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